Effects of LSD-25 on brain serotonin.
D. X. Freedman
Journal of Pharmacology and Experimental Therapeutics November 1, 1961 DOI: 10.1016/s0022-3565(25)26146-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | LSD-25 reserpine ALD-52 BOL-148 5-hydroxytryptophan |
| Dose | 130 to 1300 µg/kg LSD-25 |
| Duration | Measurements at 10 to 120 minutes and up to 96 hours after dosing |
| Topics | LSD Serotonin |
| Key findings | LSD-25 raised rat brain serotonin modestly within 10 to 120 minutes and doubled it in reserpine-treated animals, with effects lasting up to 96 hours after a single dose. The authors interpret this as LSD-25 inducing and stimulating the binding of brain serotonin, not changing its synthesis or destruction. |
Abstract
LSD-25 in doses of 130 to 1300 µg/kg induced a small and significant rise in levels of rat brain serotonin within 10 to 120 minutes following administration. A single dose was as effective as several daily doses. In reserpine treated animals, LSD-25 induced a 2-fold elevation in brain serotonin, and effects were found 96 hours following a single dose of LSD-25. A dose-effect interaction of LSD-25 and reserpine was evident. Peripheral antiserotonin potency does not correlate with the effect on brain serotonin since the order of potency in elevating brain serotonin following reserpine induced depletion was: LSD-25, ALD-52, and BOL-148. With high-speed centrifugation the effects of LSD-25 on brain serotonin are largely in the particulate fraction. LSD-25 in vivo or in vitro did not increase the destruction of serotonin or change the net synthesis of serotonin from 2 X 10-4 M 5-hydroxytryptophan. These findings are interpreted as an effect of LSD-25 on inducing binding of brain serotonin and stimulating the binding of serotonin following reserpine induced depletion.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 32
- Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Journal of Neuroscience August 1, 1988
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms Pharmacological Reviews December 16, 2020
- Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors Brain Research September 1, 1975
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