An Untoward Reaction to Accidental Ingestion of LSD in a 5-Year-Old Girl
JAMA September 11, 1967 DOI: 10.1001/jama.1967.03130110047012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 5-year-old girl |
| Intervention | d-lysergic acid diethylamide (LSD) |
| Dose | 100 μg |
| Duration | 9-month follow-up |
| Topics | LSD |
| Keywords | Depression economics Ingestion Depersonalization Audiology Clinical psychology |
| Citations | 18 |
| Key findings | A single accidental ingestion of 100μg LSD in a 5-year-old caused acute psychosis and organic brain dysfunction, with visual-motor impairment persisting for at least nine months. |
Abstract
A 5-year-old girl with an apparently normal premorbid personality and adjustment became acutely psychotic following a single accidental ingestion of 100μg of d-lysergic acid diethylamide (LSD), with agitation, panic, depression and flattening of affect, disorientation, feelings of depersonalization, distortion of body image, and depression of intellectual functioning. In addition she displayed evidences of organic brain dysfunction: impaired visual-motor and visual-perceptual functions, and abnormality of the electroencephalogram. Within days the most florid evidences of disturbance had disappeared but the thinking disorder, distortion of body image, and depression of intelligence quotient persisted for several months. At the end of five months the only residua were the abnormal EEG and disorganization of visual-motor functions. At the end of nine months only the visualmotor functions remained impaired.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
Citations in the library
Cites 7
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
- Prolonged Adverse Reactions to Lysergic Acid Diethylamide Archives of General Psychiatry May 1, 1963
- D‐Lysergic acid diethylamide (LSD): A review of its present status Clinical Pharmacology & Therapeutics March 1, 1965
- Patterns of Hallucinogenic Drug Abuse JAMA January 11, 1965
- Effects of LSD-25 on the EEG and Photic Evoked Responses Archives of General Psychiatry April 1, 1966
and 2 more in the library