Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage
William D. Loughman, Thornton W. Sargent, David M. Israelstam
Science October 27, 1967 DOI: 10.1126/science.158.3800.508 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 8 |
| Population | Human subjects with recent exposure to large doses of lysergic acid diethylamide |
| Intervention | lysergic acid diethylamide |
| Dose | large doses |
| Topics | LSD Serotonin |
| Keywords | Chromosome Genetics Physiology Biochemistry Receptor |
| Citations | 94 |
| Key findings | The number of chromosome abnormalities in leukocyte cultures from LSD-exposed subjects was not significantly greater than in controls. |
Abstract
Leukocyte cultures from eight human subjects who had had recent exposure to large doses of lysergic acid diethylamide were examined for chromosome abnormalities. The number of abnormalities was not significantly greater than that in control cultures.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 12
- The Experimental Use of Psychedelic (LSD) Psychotherapy JAMA June 15, 1970
- LSD and Genetic Damage Science April 30, 1971
- Chromosomal Effect in vivo of Exposure to Lysergic Acid Diethylamide Science June 21, 1968
- Chromosomal Damage in LSD Users JAMA April 15, 1968
- LSD and Chromosomes JAMA November 3, 1969
and 7 more in the library
Cites 3
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Persistence of lysergic acid diethylamide in the plasma of human subjects Clinical Pharmacology & Therapeutics September 1, 1964