Long Lasting Effects of LSD on Normals
Archives of General Psychiatry November 1, 1967 DOI: 10.1001/archpsyc.1967.01730290009002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Pilot study Peer reviewed |
|---|---|
| Sample size | 15 |
| Population | Normal subjects |
| Intervention | LSD |
| Dose | 200μg |
| Duration | Single session, one-week follow-up |
| Topics | LSD |
| Citations | 118 |
| Key findings | A single 200μg LSD session produced significant changes in anxiety and attitude tests one week later, but no significant changes in creativity measures. |
Abstract
THIS IS A report of a study designed to measure personality, attitude, value, interest, and performance changes resulting from the administration of LSD to normals. Several investigators using LSD with humans in nontherapy experiments have observed that some of their subjects report various lasting effects attributable to the drug experience. 1,2 In addition, the recent controversy over the nonmedical use of LSD has given rise to numerous claims and counterclaims in this regard. We have previously reported on a pilot study in which tests of anxiety, attitudes, and creativity were given to 15 subjects prior to, and one week following, a single 200μg LSD session. Some significant changes in the anxiety and attitude tests were observed, but none were found for the creativity measures. 3 The assessment of lasting effects of hallucinogens involves extradrug variables to a greater extent than do most drug studies.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 59
- Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness Journal of Psychopharmacology September 28, 2011
- Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases The Journal of Nervous and Mental Disease March 4, 2014
- Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies Journal of Psychopharmacology September 20, 2010
- Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors Journal of Psychopharmacology October 11, 2017
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
and 54 more in the library