Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster
Science October 13, 1967 DOI: 10.1126/science.158.3798.265 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Fetal hamsters |
| Interventions | mescaline lysergic acid diethylamide 2-bromo-D lysergic acid diethylamide |
| Topics | LSD Mescaline |
| Keywords | Hamster Fetus Pregnancy Teratology Exencephaly Physiology Pharmacology |
| Citations | 87 |
| Key findings | A single dose of mescaline, LSD, or 2-bromo-LSD on the 8th day of pregnancy produced malformations in multiple organs and increased fetal mortality and resorptions in hamsters. |
Abstract
Malformations of the brain, spinal cord, liver, and other viscera; body edema; and localized hemorrhages were found in fetal hamsters from mothers injected subcutaneously with a single dose of mescaline, lysergic acid diethylamide, or 2-bromo-D lysergic acid diethylamide on the 8th day of pregnancy. In addition, all three drugs produced an increase in the percentages of small fetuses per litter, of resorptions, and of fetal mortality.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 17
- LSD and Genetic Damage Science April 30, 1971
- Navajo Peyote Use: Its Apparent Safety American Journal of Psychiatry December 1, 1971
- Chromosomal Damage in LSD Users JAMA April 15, 1968
- LSD and Chromosomes JAMA November 3, 1969
- Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats Science February 16, 1968
and 12 more in the library