Chromosomal Abnormalities in Leukocytes from LSD-25 Users
Science July 21, 1967 DOI: 10.1126/science.157.3786.313 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case-control study Peer reviewed |
|---|---|
| Sample size | 17 |
| Population | LSD-25 users and nonuser controls |
| Intervention | LSD-25 |
| Duration | 1 day to 6 months after last LSD-25 dose |
| Topics | LSD |
| Keywords | Andrology Genetics Molecular biology Physiology Toxicology Dna repair mechanisms |
| Citations | 139 |
| Key findings | LSD-25 users showed a significant increase in chromosomal abnormalities in leukocytes compared to nonuser controls. |
Abstract
A significant increase of chromosomal abnormalities was found in leukocytes from LSD-25 users (six out of eight) compared to nonuser controls (one out of nine). The two LSD-25 users showing no damage reported the lowest estimated average dose. The subjects whose cells showed damage were tested between 1 day and 6 months after their last LSD-25 dose.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 25
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- LSD and Genetic Damage Science April 30, 1971
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967
and 20 more in the library