Lysergic Acid Diethylamide: Effects on the Developing Mouse Lens
Science May 2, 1969 DOI: 10.1126/science.164.3879.574 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Swiss-Webster female mice |
| Intervention | LSD-25 |
| Dose | 5 × 10⁻⁶ gram |
| Topics | LSD |
| Citations | 28 |
| Key findings | High doses of LSD-25 administered on gestation days 6-9 caused a high incidence of anterior subcapsular lens abnormalities and related lens changes in mouse offspring. |
Abstract
High doses (5 × 10- 6 gram) of LSD-25 given to Swiss-Webster females on gestation days 6, 7, 8, or 9 caused a high incidence of anterior subcapsular lens abnormalities. Accompanying this, the lens epithelium was often hyperplastic, and the lens bow was widened posteriorly in a fashion similar to cataracts induced by x-radiation. Confirmation of this effect of LSD-25 was obtained by a (duplicate) experiment 1 year after the observations reported.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 6
- LSD and Genetic Damage Science April 30, 1971
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
- Multiple Systemic and Ocular Malformations Associated With Maternal LSD Usage Archives of Ophthalmology October 1, 1974
- LSD: No Teratogenic Action in Rats, Mice, and Hamsters Science August 7, 1970
and 1 more in the library