The frequencies of spontaneous abortions, premature births, and birth defects in 121 human pregnancies following relatively infrequent, low doses of medically administered lysergic acid diethylamide are within the normal ranges. The incidence of spontaneous abortions was above average for a small sample of 27 pregnancies where LSD was ingested under both medical and nonmedical conditions....
IN attempts to work out possible mechanisms of action of the hallucinogenic drugs, it would be helpful to know which chemical groups modify their activity. In the methoxylated amphetamines, some methoxy groups may act as electrostatic binding sites and some may effect the shape and energy distribution of the π cloud. It may also be important to know whether the amino group is necessary for...
In a prospective study of 10 patients given d-lysergic acid diethylamide 25, there was no difference in frequency of chromosome breakage between samples obtained immediately before and 24 hours after treatment. In 11 patients, treated over periods ranging from 24 hours to eight years before sampling, the frequency of chromosomal breaks did not differ from that found in untreated controls. In an...
Favourable results have been reported from the use of lysergide in a wide variety of psychiatric conditions, but controlled studies (2, 3, 4) have not confirmed the existence of a therapeutic effect. In this experiment, alcoholics and neurotics who had been referred by Saskatoon psychiatrists for LSD treatment were allocated at random to Treatment and Control groups after undergoing a series of...
In spite of the many recent reports on the damaging effects of LSD on human chromosome in vitro1,2 and in vivo3-6 and its ability to produce congenital malformations in rodents7, the teratogenic potential of this drug in humans is still uncertain. Two infants with limb malformations who had been exposed to LSD in utero have thus far been reported8,9. On the other hand, Cohen, et al.5, reported...
Journal Article The Function of Music in LSD Therapy for Alcoholic Patients Get access E. Thayer Gaston, E. Thayer Gaston Project Director Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles T. Eagle, Jr. Charles T. Eagle, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Music Therapy, Volume 7, Issue 1, Spring...
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement....
The use of lysergic acid diethylamide (LSD) in the treatment of alcoholism has led to many claims as to the drug's efficacy, but without a controlled study of both in-hospital application and posthospital adjustment of patients. The present paper is concerned with the use of LSD in placebo and maximum dosages as a concomitant of a Human Relations Training Laboratory treatment program. Patients...
1. DeShon, Rinkel & Solomon, Mental Changes Experimentally Produced by LSD, 26 PSYCHIAT.Q. 33 (1952).2. Stoll & Hofmann, Partialsynthese von AlkalZiden vom Typus des Ergobasins, 26 HELvET.CHim.AcmA.944 (1943).See Laughlin, LSD-25 and the Other Hallucinogens: A Pe-Reform Proposal, 36 GEo.WAsH.L. REv. 23, 27 n.23 (1967), for a brief discussion of the history and sources of the other...
1. The in vitro iontophoretic release of tritium-labelled acetylcholine and 5-hydroxytryptamine from large and small micropipettes and noradrenaline and D-lysergic acid diethylamide from small micropipettes was determined by liquid scintillation counting.2. The release was directly proportional to the electrical charge passed in the range normally used in the iontophoretic study of these...