Cytogenetic Effects of LSD 25 Therapy in Man
JAMA December 2, 1968 DOI: 10.1001/jama.1968.03150100037008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 4 |
| Population | Patients undergoing experimental therapy with LSD 25 |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Dose | 200 μg per dose |
| Duration | One to six months follow-up after the final dose |
| Topics | LSD |
| Keywords | Physiology Dna repair mechanisms |
| Citations | 40 |
| Key findings | Chromosomal aberration frequencies increased after LSD administration but returned to control levels within one to six months after the final dose. |
Abstract
Chromosomes have been studied in leukocytes cultured from patients undergoing experimental therapy with lysergic acid diethylamide (LSD 25). Aberration frequencies prior to therapy were established for three of the four patients; these were comparable to frequencies in control subjects. Following each of three doses given intravenously (usually 200μg per dose), each patient's chromosomes were reexamined. Some increase in aberration frequency was observed, along with the appearance of some types of aberration not present before treatment. However, a return to control levels occurred in follow-up samples taken one to six months after the final dose was administered. We feel therefore that continued experimental therapy is not strongly contraindicated. On the other hand, these results can not be construed to minimize the possible cytogenetic hazards suggested by other studies concerned primarily with drug abuse.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 6
- LSD and Genetic Damage Science April 30, 1971
- LSD and Chromosomes JAMA November 3, 1969
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Effect of LSD on Human Pregnancy JAMA June 1, 1970
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
and 1 more in the library
Cites 10
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967
- Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster Science October 13, 1967
and 5 more in the library