Provided herein are novel 3-pyrrolidineindole derivatives as serotonergic psychedelic agents, pharmaceutical compositions, use of such compounds in treating psychosis and mental illnesses such as depression and post-traumatic stress disorder, and processes for preparing such compounds.
Objectives This intervention study aimed to evaluate mindfulness meditation as a method of treatment for cancer outpatients for stress reduction and control of symptoms of depression and to find out effects of socio demographic differences. Method Cancer outpatients were randomly selected on separate clinic dates at the National Cancer Institute of Sri Lanka and were enrolled as cases (n=44)...
Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties. To investigate if subcutaneous racemic ketamine, delivered twice weekly for 4 weeks, reduces anxiety in people with TRD. The Ketamine for Adult Depression Study was a multisite 4-week randomised, double-blind, active...
Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance therapy to prevent relapse. Most data supporting ketamine for treatment-resistant depression refers to the intravenous route of administration, leaving alternative routes lacking in data, especially as maintenance regimens....
To cope with chronic stress, which can contribute to depression, humans often pursue arousal-reducing activities. Yet, hormetic stressors (intermittent, acute stressors) might also reduce chronic stress. We compared the effects of arousal-reducing and arousal-enhancing interventions on depressive symptoms and perceived stress. Female adults (N = 141; predominantly White, 63%, and Asian, 34%)...
ABSTRACT Objective This pilot study assessed the feasibility and preliminary effects of an 8-week digital Mindfulness-Based Cognitive Therapy (MBCT) intervention on perinatal depression, mindfulness, well-being, and work motivation among pregnant working women. Methods The intervention included weekly online sessions and mindfulness audio guides. Pre- and post-assessments used the EPDS, TFMQ,...
A landmark systematic umbrella review by University College London researchers published in Molecular Psychiatry found no solid scientific evidence supporting the serotonin theory of depression, challenging the foundational "chemical imbalance" hypothesis underlying SSRI treatment and opening new avenues for alternative therapeutic approaches. This essay examines how the collapse of the...
Background: This study aims to specifically review the efficacy of mindfulness‐based interventions (MBIs) for breast cancer patients undergoing chemotherapy.
Abstract Traumatic brain injury (TBI) can alter day-to-day life. While changes in cognition and physical function are most often cited, emotional disturbances, notably depression, are also common. For individuals who experience depression symptoms, mindfulness-based cognitive therapy (MBCT) may afford the opportunity to address these symptoms by teaching skills to mitigate negative thought...
CNS Spectrums2025Ana Rodríguez Lorente, María Pilar Campos-Navarro, Ángela Gil Montoya et al.
Abstract Objectives This proof-of-concept study aimed to assess the impact of intranasal esketamine (ESK-IN) in brain volume and neurofilament light chain (sNfL) over 6-months in patients with treatment resistant depression (TDR). Methods Seven TRD patients received ESK-IN while continuing oral antidepressants. Clinical evaluations were conducted at baseline, 1, 3, and 6 months, with MRI scans...
Abstract Depression is the leading cause of suicide, and antidepressants and modified electroconvulsive therapy (mECT) are the preferred treatment modalities. Ketamine is an established anesthetic agent and evidence for its use in depression is evolving. Here, we discuss the experience of treating severe depression with intravenous (IV) ketamine. A patient in his mid-forties presented with a...
Major depressive disorder (MDD) significantly impairs adolescents' development, with increasing rates of treatment resistance and suicide risk. Ketamine has emerged as a promising, rapid-acting antidepressant in adults, but its efficacy and safety in adolescents remain unclear. This systematic review and meta-analysis aimed to evaluate short-term outcomes of ketamine administration in youth...
This study evaluated the effectiveness of mindfulness-based interventions (MBIs) in managing comorbid depression and diabetes by assessing their efficacy in reducing depressive symptoms and improving glycemic control, while addressing inconsistencies in existing research. A systematic review and meta-analysis were conducted of 17 randomized controlled trials published between 2013 and 2024 and...
To explore the therapeutic effect of mindfulness-based stress reduction in patients with post-stroke mild depression. A total of 80 patients with mild depression after stroke received by our hospital from January 2023 to December 2023 were selected as the study subjects. Randomly divide the patients into two groups: 40 in the control group and 40 in the combination group. The control group...
Cancer remains one of the leading causes of mortality worldwide and has a profound impact on an individual's psychological well-being. Individuals diagnosed with breast cancer often experience anxiety, depression, and reduced quality of life (QoL) due to the physical and emotional burden of the disease. Mindfulness-based interventions have emerged as effective strategies to alleviate...
Individuals with spinal cord injuries (SCI) experience depression at rates up to 5 times higher than the general population. Although research on hallucinogens for treating depression is growing, no studies have specifically focused on individuals with SCI. To identify factors associated with hallucinogen use and explore the relationship between hallucinogen use and psychosocial outcomes (i.e.,...
Adolescent mental health problems have become a public health issue of social concern in re-cent years. Compared with traditional psychological intervention methods, mindfulness meditation, as a flexible and non-invasive intervention method, has shown its potential and has gradually become a research hotspot, providing a fresh viewpoint for mental health education and practice. This article...
Trauma burden and resulting psychopathology disproportionately affect Black adults with limited socioeconomic resources. Mindfulness-Based Cognitive Therapy (MBCT) is a group-based intervention with promise for addressing trauma-related psychopathology that may be of value for Black adults with limited socioeconomic resources because it may be more approachable for individuals with mental...
This study aimed to evaluate the effectiveness of a short video app-guided mindfulness meditation intervention in improving psychological flexibility and self-compassion and reducing rumination and depressive symptoms among failed entrepreneurs. A randomized controlled trial was conducted with 100 recently failed entrepreneurs (aged 25-55), who were randomly assigned to either an intervention...
Mindfulness-Based Cognitive Therapy (MBCT) reduces depression relapse, yet graduates have expressed a need for structured guidance post-program to maintain mindfulness practice and sustain benefits. To address this, we created MBCT for Depression-Taking it Further (MBCT-D-TiF). To refine and pilot test feasibility and acceptability of MBCT-D-TiF. We collected qualitative focus group data to...