CNS DrugsJune 1, 2025Sijia Zhang, Houtan Afshar, Peter J. Colvonen et al.1 citation
Ketamine and esketamine are increasingly used to manage treatment-resistant depression and have also been shown to reduce symptoms of posttraumatic stress disorder (PTSD). Little is known about how common comorbidities in the veteran population, such as traumatic brain injury (TBI) or obstructive sleep apnea (OSA), may influence ketamine and esketamine treatment outcomes. In this retrospective...
N-methyl-D-aspartate receptors (NMDA receptors) play a crucial role as ionotropic glutamate receptors in regulating neuroplasticity, learning, memory, and a range of psychiatric disorders. Studies indicate that dysfunction of NMDA receptors is a key pathological mechanism in depression, where abnormal activation can result in neuronal excitotoxicity, excessive extracellular calcium ion...
Aim: This study aimed to estimate the economic impacts of expanded access to ketamine relative to electroconvulsive therapy (ECT) by offering intravenous ketamine to US patients with nonpsychotic treatment-resistant depression (TRD) and moderate-to-severe depression. Materials & methods: A population-level Markov simulation model with key parameters from a randomized trial was used to simulate...
Empathy plays a crucial role in interpersonal relationships and mental health. It is decreased in a variety of psychiatric disorders including major depression. Psilocybin, a promising candidate for treating depression, has been shown to acutely increase emotional empathy in healthy volunteers. However, no study has investigated this effect and its relevance for symptom improvement in a...
Although long known for their psychoactive effects, psychedelic drugs have only recently been investigated for medicinal use. Psilocybin has attracted the greatest interest with studies suggesting that it may be a useful agent in psychiatry and in palliative care. Clinical trials that included psilocybin were searched in PubMed, Embase, and ClinicalTrials.gov, demonstrating that adult...
Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in...
This systematic review assessed use of third-wave psychotherapies in reducing psychological distress and improving psychological well-being and quality of life in people with Parkinson's disease and critically evaluated intervention adaptations. A literature search, conducted across five databases identified randomized controlled trials (RCTs) evaluating third-wave psychotherapies for...
A large number of studies have demonstrated the effectiveness of mindfulness- based cognitive therapy (MBCT) in the adjuvant treatment of depression, and the significant effect of MBCT in inhibiting the recurrence of depression, most of these studies are randomized controlled trials. These studies compared a group of MBCT combined with conventional treatment and conventional treatment to ensure...
Depression has become a critical mental health issue, especially among college students, with increasing prevalence worldwide. According to the World Health Organization (WHO), approximately 322 million people globally suffer from the condition, with a prevalence rate of around 3.7% in Indonesia. This research examines the effectiveness of spiritual mindfulness therapy in reducing depression...
The prevention and management of cerebrovascular diseases, particularly cerebral infarction - the most prevalent type of cerebrovascular disease - pose significant challenges, severely affecting patients' physical and mental health. Mindfulness-based cognitive therapy (MBCT) has been shown to be effective in treating various mental and chronic conditions. However, there is limited evidence on...
Our study sought to evaluate whether increased mindfulness and social support mediated the effect of the Amigas Latinas Motivando el Alma (ALMA) intervention on depression and anxiety among Latina immigrant women. The study was a secondary analysis of data from a trial evaluating the ALMA intervention with a delayed-intervention comparison group design. Latina immigrants (n = 226) were...
Abstract Objective Ketamine and esketamine have both shown significant antidepressant effects in treatment-resistant depression (TRD) and conflicting evidence suggests that dissociation induced by these drugs could be a clinical predictor of esketamine/ketamine's efficacy. Methods This study is a secondary analysis of data from a two-center, randomized, controlled trial. Participants were...
Mindfulness has been consistently linked to mental health benefits; however, the underlying mechanisms relating mindfulness to life satisfaction and depression remain underexplored. This study develops and empirically examines the Dual Pathways Mindfulness Model (DPMM), which posits that mindfulness is associated with mental health through sequential mechanisms involving self-compassion and...
medRxivMay 27, 2025Colin G Walsh, Michael Ripperger, Thomas H McCoy et al.
preprint
As multiple strategies have emerged for managing treatment-resistant major depressive disorder, efficient identification of individuals at elevated risk for this outcome earlier in their illness course remains essential. We extracted electronic health records data for all individuals with a diagnosis of major depressive disorder who received an index antidepressant prescription in the clinical...
Mindfulness-based interventions (MBIs) are effective in improving mental and physical health in various chronic conditions. While the GOLD 2024 report recommends MBIs for chronic obstructive pulmonary disease (COPD), scientific evidence in this specific population is scarce. This prospective randomised controlled pilot study investigated the feasibility of an 8-week digital MBI and its...
Over the past years, a number of clinical and preclinical investigations have been documented, suggesting treatment strategies and pharmaceuticals for neuropathic pain and depressive disorders, potentially beneficial in cases where these conditions are comorbid. This review lists these potential treatment options and discusses the proposed underlying mechanisms of action and their limitations,...
Major depressive disorder (MDD) is a leading cause of disability that affects over 300 million people globally. Despite multiple antidepressant trials, approximately one-third of MDD patients remain symptomatic, progressing to treatment-resistant depression (TRD). This persistence possibly is due to the multifaceted etiology of TRD, encompassing biological, psychological, and environmental...
Mindfulness, defined as the ability to be fully aware and attentive to the present moment without judgment, has sparked growing interest in the therapeutic approach to anxiety disorders and depression. The objective of this narrative review is to provide a historical overview of the definition of mindfulness, the clinical implications of this practice based on Buddhist philosophy, and analyze...
To summarise and critically appraise the evidence of mindfulness-based interventions for psychological distress in patients with cancer and their partners. A critical review. The critical appraisal checklists of the Centre for Evidence-Based Management were utilised for the quality appraisal while reporting the results using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
Nursing students experience disproportionately high rates of mental health challenges, underscoring the urgent need for innovative, scalable interventions. Web-based mindfulness programs, and more recently, neurofeedback-enhanced approaches, present potentially promising avenues for addressing this critical issue. This study aimed to explore the effectiveness of the neurofeedback-assisted...