Journal of Cannabis Research
October 30, 2026
Maria Vitória Dos Santos Villa Bande, Ana Cristi Basile Dias, Fernanda Vasconcelos De Almeida et al.
Abstract: Background: Cannabis sativa L. is one of the most versatile plants used by different cultures worldwide as a source of food, fiber, and medicine. Due to the variability of Cannabis, research on this plant and the standardization of medications and Cannabis-based products prove to be challenging. This study aimed to optimize and validate a high-performance liquid chromatography method...
Journal of Cannabis Research
October 24, 2026
Gabriel Zoobi, Mackenzie Marco, Khalid J. Foraida et al.
Abstract: Background: Consumer- and patient-facing cannabis products are commonly labeled “indica,” “sativa,” or “hybrid” to signal expected composition or effects. We systematically reviewed whether these labels predict cannabis composition, animal effects, or human outcomes. Methods: We last searched PubMed/MEDLINE, Europe PMC, PubPsych, OpenAlex, and ClinicalTrials.gov, supplemented by...
Journal of Cannabis Research
August 26, 2026
Ario Safaeian, Kaylen M. Young, John G. Howland et al.
Abstract Background Cannabis use has increased in recent years due to legalization. Smoking cannabis leads to inhalation of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in addition to other particles and gas in the smoke matrix as a result of combustion. The effect of THC on breathing pattern and metabolism has been characterized, but the influence of CBD and the smoke matrix on...
Journal of Cannabis Research
March 24, 2026
F. Huppé-Gourgues, Natalie Spridzans, S. Lamarre et al.
Cannabis and its primary psychoactive component, Δ9-tetrahydrocannabinol (THC), are increasingly studied for their pharmacological effects, yet little is known about their pharmacokinetics in non-human primates. This study aimed to characterize the pharmacokinetic profile of THC and its metabolites following oral administration in vervet monkeys under both acute and short chronic exposure...
Journal of Cannabis Research
January 2, 2026
Sunitha Vemuri, Samantha M. Ayoub, Arpi Minassian et al.
Cannabinoids have proven to useful for attenuating adverse effects of HIV. People living with HIV use cannabis at higher rates, with evidence suggesting it alleviates physiological symptoms such as nausea, loss of appetite, etc.. Cannabis can alter physiology as well as essential behavioral functions such as motivation. This study investigated the effect of delta-9-tetrahydrocannabinol (THC),...
Journal of Cannabis Research
May 31, 2025
Michael Von Gunten, Seth Hoffman, Addison Smartt et al.
Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in...
Journal of Cannabis Research
May 23, 2025
Margy Y. Chen, Ashley Brooks-Russell, Angela D Bryan et al.
As cannabis products become increasingly accessible and novel modes of administration like dabbing and vaping gain popularity, understanding how these modes impact use experiences and abuse liability is crucial. Existing studies primarily utilized laboratory settings with lower-potency research-grade cannabis, failing to capture common modes among individuals who use higher-potency legal market...
Journal of Cannabis Research
July 11, 2024
Cianna J Piercey, Eleftherios M Hetelekides, Hollis C Karoly
5 citations
Background: Most studies examining the simultaneous use of cannabis with other drugs have focused on cannabis and alcohol, with fewer studies examining simultaneous use of cannabis with other drugs. The United States is currently experiencing an upward trend in psychedelic use and there is an increasing need to characterize cannabis and psychedelic drug interactions to best inform public health...
Journal of Cannabis Research
May 31, 2024
S Zhao, Bruna Brands, Pamela Kaduri et al.
13 citations
Cannabis has been shown to impact driving due to changes produced by delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis. Current legal thresholds for blood THC while driving are based predominantly on evidence utilizing smoked cannabis. It is known that levels of THC in blood are lower after eating cannabis as compared to smoking yet the impact of edibles on driving and...
Journal of Cannabis Research
May 3, 2024
Cristian Caprari, Elena Ferri, M. Vandelli et al.
Since its discovery as one of the main components of cannabis and its affinity towards the cannabinoid receptor CB1, serving as a means to exert its psychoactivity, Δ^9-tetrahydrocannabinol (Δ^9-THC) has inspired medicinal chemists throughout history to create more potent derivatives. Initially, the goal was to synthesize chemical probes for investigating the molecular mechanisms behind the...
Journal of Cannabis Research
February 3, 2024
Ashley Brooks-Russell, Julia Wrobel, Tim Brown et al.
Background Acute cannabis use has been demonstrated to slow reaction time and affect decision-making and short-term memory. These effects may have utility in identifying impairment associated with recent use. However, these effects have not been widely investigated among individuals with a pattern of daily use, who may have acquired tolerance. The purpose of this study was to examine the impact...
Journal of Cannabis Research
November 9, 2023
Jussi Jylkkä, Aleksi Hupli, Aleksandra Nikolaeva et al.
Medical cannabis (MC) is increasingly used for chronic pain, but it is unclear how it aids in pain management. Previous literature suggests that MC could holistically alter the pain experience instead of only targeting pain intensity. However, this hypothesis has not been previously systematically tested. A retrospective internet survey was used in a sample of Finnish chronic pain patients (40...
Journal of Cannabis Research
July 26, 2023
Lee Johnson, Marc Malone, Erik R. Paulson et al.
Background Hemp-derived delta-9 tetrahydrocannabinol (∆^9 THC) products are freely available for sale across much of the USA, but the federal legislation allowing their sale places only minimal requirements on companies. Products must contain no more than 0.3% ∆^9 THC by dry weight, but no limit is placed on overall dosage and there is no requirement that products are tested. However, some...
Journal of Cannabis Research
February 8, 2023
J. Vigil, S. Stith, Franco Brockelman et al.
Background Little is known about the frequency with which different combinations of phytochemicals (chemovars) arise in Cannabis flower or whether common chemovars are associated with distinct pharmacodynamics and patient health outcomes. This study created a clinically relevant, user-friendly, scalable chemovar indexing system summarizing primary cannabinoid and terpene contents and tested...
Journal of Cannabis Research
September 28, 2022
Gita Bania
AbstractBackgroundThe emergence of colonial medicine in the North-Eastern Frontier witnessed different phases of consistent competition and resistance. Herbs such as cannabis provided native physicians with a coherent power to resist colonial medical intervention. Before British rule, cannabis assumed great significance in the socio-economic, cultural, and religious spheres. The colonizers’...
Journal of Cannabis Research
May 18, 2022
Whitney L Ogle, Gregg J Gold, Lukas E Coppen et al.
Background: With increased legalization of cannabis, users are combining cannabis with exercise. The purpose of this study is to understand how and why people use cannabis when participating in physical activity. Methods: A convenience sample of cannabis users participated in an anonymous online survey created by the authors regarding exercise habits while under the influence of cannabis,...
Journal of Cannabis Research
January 4, 2022
J. Kruger, Daniel J. Kruger
Background Products containing delta-8-THC became widely available in most of the USA following the 2018 Farm Bill and by late 2020 were core products of hemp processing companies, especially where delta-9-THC use remained illegal or required medical authorization. Research on experiences with delta-8-THC is scarce, some state governments have prohibited it because of this lack of knowledge....
Journal of Cannabis Research
September 22, 2020
Petter Grahl Johnstad
29 citations
BACKGROUND: While cannabis has a long history of spiritual use, its normalization in Western societies during the last decades has led to more recreational use. This study aimed to explore the characteristics of spiritual cannabis use as compared to recreational use and to the use of psychedelics such as LSD and psilocybin. METHODS: The study employed a mixed methods research design that...
Journal of Cannabis Research
July 17, 2020
Laura Alethia de la Fuente, Federico Zamberlán, Andrés Sánchez Ferrán et al.
30 citations
BACKGROUND: Widespread commercialization of cannabis has led to the introduction of brand names based on users' subjective experience of psychological effects and flavors, but this process has occurred in the absence of agreed standards. The objective of this work was to leverage information extracted from large databases to evaluate the consistency and validity of these subjective reports, and...