Scientific Reports
May 26, 2025
Zitong Wang, Brett Robbins, Ryan Zhuang et al.
4 citations
Major depressive disorder (MDD) is a leading cause of disability that affects over 300 million people globally. Despite multiple antidepressant trials, approximately one-third of MDD patients remain symptomatic, progressing to treatment-resistant depression (TRD). This persistence possibly is due to the multifaceted etiology of TRD, encompassing biological, psychological, and environmental...
Research Square
May 6, 2025
Zitong Wang, Brett Robbins, Ryan Zhuang et al.
Abstract Major depressive disorder (MDD) is a leading cause of disability that affects over 300 million people globally. Despite multiple antidepressant trials, approximately one-third of MDD patients remain symptomatic, progressing to treatment-resistant depression (TRD). This persistence possibly is due to the multifaceted etiology of TRD, encompassing biological, psychological, and...
The International Journal of Neuropsychopharmacology
February 1, 2025
Zitong Wang, Yanbo Zhang, Xin-Min Li
Abstract Background Dr. George Engel introduced the biopsychosocial model into the field of psychiatry 40 years ago, highlighting the profound connection between social environment and mental health. Factors have been categorized into biological, psychological, and socio-environmental domains. Numerous animal models have been developed to investigate the pathophysiology and treatment of...
Progress in Neuro-psychopharmacology and Biological Psychiatry
2025
Zitong Wang, Brett Robbins, Ryan Zhuang et al.
15 citations
Chronic stress exerts profound effects on mental health, contributing to disorders such as depression, anxiety, and cognitive impairment. This study examines the potential of psilocybin to alleviate behavioral despair and cognitive deficits in a rodent model of chronic stress, focusing on the interplay between the Hypothalamic-Pituitary-Adrenal (HPA) axis and the Endocannabinoid System (ECS)....