A presente tese foi dividia em dois capítulos. Capítulo I. Esse capítulo tem como objetivo investigar o possível potencial de reforço induzido pela ayahuasca por meio do paradigma de preferência condicionada por lugar (conditioned place preference, CPP), bem como avaliar se a ayahuasca é capaz de modular a CPP induzida pela cocaína durante as fases de aquisição, expressão e reinstalação da CPP...
Psychedelics offer promising outcomes in psychiatry. However, the preparation of participants (set) and the environmental conditions of taking a psychedelic (setting) are not standardized. We describe the set and setting for therapeutic use of psychedelic drugs in people with psychiatric disorders. In this systematic review, articles were identified in the PubMed and Web of Science databases...
Ischemic stroke is a leading cause of death and disability worldwide. Survivors face disability and psychiatric sequelae resulting from ischemia-induced cell death and associated neuroinflammation, and oxidative stress. Herbal medicines have been shown to elicit neuroprotective effects following stroke due to their anti-inflammatory and antioxidant effects. Preliminary evidence suggests that...
O psicodélico clássico ayahuasca, e a substância rapé, também utilizadas em rituais xamânicos com o uso da ayahuasca, eliciam estados de consciência podendo alterar a percepção temporal dos seres humanos. Estudos envolvendo tarefas de reprodução do tempo e psicodélicos clássicos mostram que estas substâncias alteram a percepção temporal em estímulos superiores a 1,6 segundos. A literatura...
The psychoactive decoction Ayahuasca (AYA) used for therapeutic and religious purposes by indigenous groups and peoples from Amazonian regions produces anti-inflammatory and neuroprotective effects. Thus, it may be useful to attenuate the neuroinflammation and related anxiety- and depressive-like symptoms elicited by inflammatory insults such as sepsis. Rats were pretreated for 3 days with...
SciELO PreprintsApril 28, 2025Yasmine Jurdi Jasserand, Ana Beatriz Vieira de Oliveira, Andressa De Queiroz et al.
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Objective: To explore the therapeutic potential of Ayahuasca as a complementary intervention in the treatment of psychiatric disorders, assessing its reported effects, the challenges for its clinical application, and considering its historical use in Amazonian traditions. Method: A systematic review of the literature was conducted using the PubMed and SciELO databases, selecting studies...
The human psyche's interaction with death fundamentally shapes cognition, emotions, and behavior in both individuals and society. Death-related psychological phenomena have been shown to be influenced by psychedelic interventions. However, the literature lacks a comprehensive assessment of death-related processes in non-clinical settings, the mechanisms underlying long-term changes, and...
Research on the positive psychological effects of psychedelics has surged since the early 2000s, particularly regarding increased well-being. Studies have demonstrated how psychedelic-occasioned mystical experiences play a key role in their positive effects, which has prompted an interest in the emotion of awe in the psychedelic context due to its similar phenomenology and associated benefits....
Este estudo volta-se para os saberes da ayahuasca, beberagem de origem indígena feita da combinação de um cipó e as folhas de um arbusto da Amazônia, utilizada em diferentes contextos culturais como é o caso da religião brasileira conhecida como Santo Daime. Parto do pressuposto, afirmado nos próprios hinos da doutrina, de que o daime (ayahuasca) é um profesor e que na religião vivencia-se um...
A experiência com a ayahuasca e estados não ordinários de consciência envolve visões simbólicas, acesso ao inconsciente e uma percepção alterada da realidade. Sua natureza metafísica desafia as categorias convencionais de linguagem e representação, sendo frequentemente descrita como inefável. Embora a arte, em qualquer contexto, possua um grau de inefabilidade, a arte visionária que busca...
PlantsApril 7, 2025Thais A C Santos, Bruno S Amorim, Jefferson R Maciel et al.1 citation
Banisteriopsis is a genus in the Malpighiaceae family with 61 species, notable for including ritualistic taxa such as B. caapi (Spruce ex Griseb.) C.V. Morton, one of the main components of Ayahuasca tea. We analyzed 38 Banisteriopsis species, representing more than 60% of the genus, to investigate its geographical origin, diversification period, and colonization routes in the Neotropics....
European PsychiatryApril 1, 2025E. E. Morales Castellano, P. Rivero Rodríguez, Marina Martínez Grimal et al.
Introduction The relationship between psychosis and ayahuasca use is a topic of considerable interest and debate in the scientific and medical community. Ayahuasca is traditionally used in shamanic ceremonies in the Amazon, composed mainly of the Banisteriopsis caapi vine and the leaves of Psychotria viridis, which contain DMT (dimethyltryptamine), a powerful hallucinogen. Ayahuasca induces...
Ayahuasca is an Amazonian brew with 5-HT2A-dependent psychedelic effects taken by religious groups globally. Recently, psychedelics have been shown to impair the formation of recollections (hippocampal-dependent episodic memory for specific details) and potentially distort memory while remembering. However, psychedelics spare or enhance the formation of familiarity-based memory...
Psychedelic-assisted therapy is gaining recognition for its potential to enhance human functioning. While most research has focused on psychedelic' therapeutic use for mental illness, this review applies the PERMA Theory of Well-Being to systematically examine their role in enhancing well-being in healthy individuals. The final search of five academic databases was conducted on February 4,...
This retrospective case study features a woman in her mid-50s who spent her childhood in a religious community plagued by sexual abuse of children. She was abused by her father for more than a decade. The church and her mother ignored her reports about it. In her early twenties, she enrolled herself in the Erhard Seminars Training program that destabilized her, inducing a first-onset psychosis,...
Banisteriopsis caapi (Spruce ex Griseb.) Morton, a vine native to South America and belonging to the Malpighiaceae plant family, is well known for its role as a primary component in the renowned psychoactive beverage known as ‘ayahuasca’, which also includes the herb Psychotria viridis Ruiz & Pav. Ethnic groups have historically employed the concoction for ceremonial, therapeutic, and...
Research SquareMarch 5, 2025Expedito Do Nascimento Júnior, Luiz Pereira, Wigínio Lira-Bandeira et al.
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Abstract Depression remains a debilitating mental health disorder affecting millions worldwide, with growing prevalence among adolescents. Recent studies highlight the critical role of the somatosensory cortex in the neuropathology of depression, including structural alterations that impair cortical function. This study investigates the prophylactic effects of ayahuasca, a traditional...
Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on understanding the long-term use influence of these substances on these variables, especially in ritualistic contexts. To verify the influence of ritualistic ayahuasca consumption on the cognition of experienced ayahuasca religious users (> 20 years) and...
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydroharmine) monoamine oxidase inhibitors. However, the pharmacological interactions between these compounds remain incompletely understood. In this study, we developed an ayahuasca-inspired formulation containing DMT and harmine, aiming to...
This article explores the multifaceted therapeutic and psycho-spiritual dimensions of ayahuasca within the framework of a unified integrative model of medicine. Ayahuasca, a traditional South American brew with rich ceremonial roots, has gained global recognition for its ability to catalyse profound psychological and spiritual transformations. Highlighting its historical, cultural, and...