Research published in European Archives of Psychiatry and Clinical Neuroscience

Esketamine multi-omic biomarker evaluation in major depressive disorder (EMBER-MDD): concept, objectives and methodologies of a non-clinical investigator-initiated study.

European Archives of Psychiatry and Clinical Neuroscience June 30, 2026 C Hohoff, T Lange, L Steinbach et al.

Treatment resistance (TR) in major depressive disorder (MDD) affects a substantial minority of patients and is hard to recognize early, delaying intensified care. The Esketamine multi-omic biomarker evaluation in MDD (EMBER-MDD) is a non-interventional, investigator-initiated, in-vitro study within the EU Psych-STRATA programme, analyzing biospecimens collected in the randomized INTENSIFY study...

DOI: 10.1007/s00406-026-02306-x Full text Depression Esketamine Integrative multi-omics Molecular omics +1

Dissociative experiences and self-reported interoceptive traits in maladaptive daydreamers: a network analysis

European Archives of Psychiatry and Clinical Neuroscience June 23, 2026 Ilaria Bufalari, Lilya Abergel, Andrea Zagaria et al.

Maladaptive Daydreaming (MD) is a proposed mental health condition characterized by compulsive, immersive daydreaming that interferes with daily functioning. Although MD is strongly associated with dissociative experiences, its relation to interoception remains unexplored. In this study, we investigated dissociative symptoms and self-reported interoception in individuals with MD compared to...

DOI: 10.1007/s00406-026-02296-w Full text Interoception Dissociation chemistry Dissociative disorders Cognition +5

Efficacy of mindfulness-based cognitive therapy in mitigating depressive symptoms and suicidal ideation among institutionalized patients with major depressive disorder: findings from a randomized controlled trial.

European Archives of Psychiatry and Clinical Neuroscience June 12, 2026 Zulkiflu Musa Argungu, Ali Alhaiti, Ebtesam Abdulrahman Jibreel

Major Depressive Disorder (MDD) represents a significant global health challenge, with elevated risks of suicidal ideation. This study evaluated the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) in mitigating depressive symptoms and suicidal ideation among institutionalized patients with MDD in Nigeria. A randomized controlled trial was conducted with 101 participants (MBCT: n = 50,...

DOI: 10.1007/s00406-026-02288-w Full text Major depressive disorder Mindfulness-based cognitive therapy Randomized controlled trial Suicidal ideation

Anomalous self-experiences in biotypes of psychosis

European Archives of Psychiatry and Clinical Neuroscience June 5, 2026 Luis Sobrino-Conde, Antonio Arjona, Emma Osorio-Iriarte et al.

Biotypes of psychoses represent transdiagnostic clusters based on pathological characteristics relevant to this syndrome. This approach seeks to help with the delimitation of groups with external validity within the psychotic syndrome beyond current categories. Our group has previously proposed two biotypes characterized by different cognitive performance and anatomical and functional...

DOI: 10.1007/s00406-026-02257-3 Full text Cognition Psychosis Pathological Schizophrenia object-oriented programming +3

Therapeutic effects of psilocybin in major depressive disorder: a systematic review and meta-analysis exploring dose effects.

European Archives of Psychiatry and Clinical Neuroscience June 1, 2026 Ziping He, Yijie Wang, Jiemin Chen et al. 1 citation

BACKGROUND: Several recent trials indicate positive effects of psilocybin in patients with major depressive disorder. However, questions need to be addressed regarding the relationship between dosage and therapeutic outcomes, such as the recommended dose range and frequency for optimal practice as well as the dose-dependent adverse effects. OBJECTIVE: (1) to assess the effectiveness and...

DOI: 10.1007/s00406-025-02165-y Full text Major depressive disorder Psilocybin Dose-response relationship Meta-analysis

Effect of meditation on clinical symptoms and gray matter volume in chronic schizophrenia: a randomized controlled trial.

European Archives of Psychiatry and Clinical Neuroscience May 19, 2026 Mi Yang, Yuzheng Ma, Jialong Huang et al.

The neurobiological mechanisms underlying the therapeutic effects of meditation therapy in patients with schizophrenia remain poorly understood, therefore, we aim to investigate the relationship between clinical symptoms and the structural changes in brain gray matter in a meditation intervention trial. Han inpatients with schizophrenia admitted to the Shanghai First Civil Affairs Mental Health...

DOI: 10.1007/s00406-026-02271-5 Full text Meditation Chronic schizophrenia Clinical symptoms Gray matter volume +2

Poor insight and self-disorders in schizophrenia: an empirical study.

European Archives of Psychiatry and Clinical Neuroscience April 1, 2026 Lars Siersbæk Nilsson, Julie Nordgaard, Mads Gram Henriksen et al. 5 citations

Poor insight is a core feature of schizophrenia and empirical studies have demonstrated associations with important symptom domains, cognitive functions, and clinical outcomes. While recent explanatory accounts mostly focus on neuro-, social-, or meta-cognitive deficits, a complementary model from phenomenological psychopathology suggests that impaired insight in schizophrenia is tied to...

DOI: 10.1007/s00406-025-02035-7 Full text Phenomenology Ease Psychopathology Psychosis +1

Mapping cognitive-behavioral approach in psychedelic-assisted treatment: a systematic review across phases with classic and non-classic psychedelics

European Archives of Psychiatry and Clinical Neuroscience March 28, 2026 Yves Martins Varela, Vagner Deuel O de Tavares, Luiza Macedo Delgado et al. 1 citation

The use of psychedelics in the treatment of psychopathologies has been expanding, highlighting Psychedelic-Assisted Psychotherapy (PAP) as a promising resource in mental health care. This systematic review investigates. This systematic review investigates whether and how cognitive-behavioral therapies are integrated with psychedelic substances—both classical and atypical—for the treatment of...

DOI: 10.1007/s00406-025-02188-5

Nightmare frequency mediates the association between childhood trauma and suicidal ideation among youth: is it sex-specific?

European Archives of Psychiatry and Clinical Neuroscience November 17, 2025 Jianyu Que, Yan’e Lu, Jingrou Liu et al.

Childhood trauma has been found to be associated with suicidal ideation among youth. However, the underlying processes that link childhood trauma and suicidal ideation are unclear. This study investigates the role of nightmare frequency in the association between childhood trauma and suicidal ideation, and the potential moderating effect of sex. Youths were recruited from Fujian Province,...

DOI: 10.1007/s00406-025-02149-y Full text Nightmare Suicidal ideation Association psychology Mediation +6

The boon and bane of nitrous oxide.

European Archives of Psychiatry and Clinical Neuroscience September 1, 2025 Golo Kronenberg, Georgios Schoretsanitis, Erich Seifritz et al.

Nitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be...

DOI: 10.1007/s00406-024-01801-3 Full text Depression Abuse Homocysteine Methylmalonic acid +2

Intranasal esketamine significantly alleviates depression severity and suicidal ideations in electroconvulsive therapy (ECT) non-responders.

European Archives of Psychiatry and Clinical Neuroscience July 1, 2025 Erhan Kavakbasi, Kevin Rosemann, Mert Yilmaz et al. 2 citations

Intranasal esketamine (ESK) is a novel therapy option in patients with treatment-resistant depression (TRD). Patients with a history of electroconvulsive therapy (ECT) non-response (ECT+) in the current episode have usually been excluded from previous studies. Data on the effectiveness of ESK in ECT non-responders are sparse. In this retrospective study, we investigated the effectiveness of...

DOI: 10.1007/s00406-025-02041-9 Full text Esketamine Major depressive disorder Electroconvulsive therapy Novel antidepressants +1

Influence of recent cannabis use on altered spectral entropy modulation and connectivity strength in patients with psychosis

European Archives of Psychiatry and Clinical Neuroscience June 23, 2025 Vicente Molina, Á. Díez, Inés Fernández-Linsenbarth et al.

Cannabis use is highly prevalent in individuals with psychosis, raising concerns about its influence on brain function. Electroencephalography (EEG) studies have identified alterations in brain activity in psychosis, including changes in spectral entropy (SE) modulation and connectivity strength (CS). However, the degree to which cannabis use contributes to these alterations remains unclear....

DOI: 10.1007/s00406-025-02004-0 Full text

Adjunctive use of mindfulness-based mobile application in depression: randomized controlled study.

European Archives of Psychiatry and Clinical Neuroscience June 1, 2025 Jan Sarlon, Else Schneider, Annette B Brühl et al. 2 citations

Mindfulness-based interventions (MBI) are effective in relapse prevention in Major Depressive Disorder (MDD). Internet-based interventions have been demonstrated to be effective in the treatment of MDD. Consequently, the integration of MBI through mobile applications emerges as a promising supplementary intervention for MDD, contributing to the augmentation of mental health services,...

DOI: 10.1007/s00406-024-01884-y Full text Depression Mindfulness Mobile application Stress level

Nightmare frequency and nightmare distress in psychiatric inpatients.

European Archives of Psychiatry and Clinical Neuroscience June 1, 2025 Michael Schredl, Elisabeth Anzenberger, Claudia Schilling

Previous research indicated that the prevalence of frequent nightmares and/or the presence of a nightmare disorder is quite high in patients with mental disorders. In the present study, 75 randomly selected psychiatric inpatients were interviewed and completed questionnaires regarding nightmares, sleep, and psychopathology. The percentage of patients with nightmares once per week or more often...

DOI: 10.1007/s00406-024-01891-z Full text Depression Mental disorders Nightmare distress Nightmare frequency

The correlation between cumulative burden of mental disorders and self-harm, shame, and insight in young female patients with schizophrenia.

European Archives of Psychiatry and Clinical Neuroscience April 1, 2025 Hua Xue, Chaomin Wang, Yongjian Tian et al.

This study delves into the correlation between the cumulative burden of mental disorders and self-harm, shame, and insight in young female patients with schizophrenia. A prospective randomized controlled study was used to recruit 62 female schizophrenia patients who met the recruitment conditions from January 2022 to December 2023. The participants were randomly divided into an experimental...

DOI: 10.1007/s00406-024-01860-6 Full text Insight Mental disorders Schizophrenia Self-harm +2

Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users.

European Archives of Psychiatry and Clinical Neuroscience March 1, 2025 Arilton Martins Fonseca, Rafael Guimarães Dos Santos, Lívia Soman de Medeiros et al. 10 citations

Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on understanding the long-term use influence of these substances on these variables, especially in ritualistic contexts. To verify the influence of ritualistic ayahuasca consumption on the cognition of experienced ayahuasca religious users (> 20 years) and...

DOI: 10.1007/s00406-024-01817-9 Full text Banisteriopsis caapi Psychotria viridis Cognition Santo daime +9

What Chemsex does to the brain - neural correlates (ERP) regarding decision making, impulsivity and hypersexuality.

European Archives of Psychiatry and Clinical Neuroscience February 1, 2025 Johanna Schwarz, Marcus Gertzen, Andrea Rabenstein et al. 14 citations

Chemsex describes the use of specific substances (methamphetamine, GHB/GBL, mephedrone, ketamine) which initiate or enhance sexual experiences and is mainly prevalent among men who have sex with men. Many Chemsex users experience somatic complications (for example sexually transmitted diseases) and sometimes adverse sociological, psychological, and neurological symptoms, such as depression,...

DOI: 10.1007/s00406-024-01856-2 Full text Chemsex Executive functions Hypersexuality Inhibition +2

Arketamine: a scoping review of its use in humans.

European Archives of Psychiatry and Clinical Neuroscience December 16, 2024 Gustavo C. Leal, Isabel Lima-Araújo, David G Roiter et al. 7 citations

Arketamine (R-ketamine), an enantiomer of ketamine, has historically been less studied than esketamine (S-ketamine) and the racemic mixture. Recent preclinical studies suggest that arketamine may offer prolonged antidepressant effects and a superior safety profile. This scoping review aims to assess and synthesise existing literature on the clinical use of arketamine in humans. This review...

DOI: 10.1007/s00406-024-01945-2 Full text Arketamine R-ketamine Antidepressant Pain management +4

Combination of non-invasive brain stimulation with mindfulness-based interventions for anxiety and depression symptoms: systematic review and meta-analysis of randomized controlled trials.

European Archives of Psychiatry and Clinical Neuroscience November 17, 2024 Anastasia Demina, Benjamin Petit, Vincent Meille et al. 6 citations

In this article we aimed synthesize all available evidence regarding the effects of non-invasive brain stimulation (NIBS) techniques combined with mindfulness-based interventions (MBIs) on mental health indicators. We performed a systematic review of randomized controlled trials evaluating NIBS/MBIs combinations in clinical populations and a random effects pairwise meta-analysis of studies...

DOI: 10.1007/s00406-024-01928-3 Full text Anxiety Depression Neuroplasticity Bimodal treatment +2

Ketamine-induced altered states of consciousness: a systematic review of implications for therapeutic outcomes in psychiatric practices.

European Archives of Psychiatry and Clinical Neuroscience October 28, 2024 Kaike Thiê da Costa Gonçalves, Vagner Deuel O de Tavares, Maria Luiza de Morais Barros et al. 5 citations

This systematic review aims to elucidate the nexus between ketamine's psychoactive properties and its efficacy in treating a broad spectrum of psychiatric disorders. We searched three databases and used citation tracking to include 29 studies. Predominantly, mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD) (MDD + BD: + n = 25 studies), a large part of them...

DOI: 10.1007/s00406-024-01925-6 Full text Anxiety Depression Psychedelic-assisted therapy Addiction +8

Efficacy of racemic ketamine or esketamine monotherapy for reducing suicidal ideation in uni- or bipolar depression: a systematic review and meta-analysis.

European Archives of Psychiatry and Clinical Neuroscience October 9, 2024 Jiafeng Li, Ling Ma, Huan Sun et al. 5 citations

The current systematic review and meta-analysis examined the effect of racemic ketamine or esketamine on suicidal ideation in individuals with uni- or bipolar depression. We searched the MEDLINE, Embase, Central, PsycINFO, and Web of Science databases to identify randomized controlled trials that examined the effect of racemic ketamine or esketamine monotherapy on suicidal ideation (SI) in...

DOI: 10.1007/s00406-024-01920-x Full text Major depressive disorder Mdd Bipolar disorder Meta-analysis +8

Synaptic basis of rapid antidepressant action.

European Archives of Psychiatry and Clinical Neuroscience September 29, 2024 Ege T Kavalali, Lisa M Monteggia 4 citations

The discovery of ketamine's rapid antidepressant action has generated intense interest in the field of neuropsychiatry. This discovery demonstrated that to alleviate the symptoms of depression, treatments do not need to elicit substantive alterations in neuronal circuitry or trigger neurogenesis, but rather drive synaptic plasticity mechanisms to compensate for the underlying pathophysiology....

DOI: 10.1007/s00406-024-01898-6 Full text Synaptic plasticity Bdnf Homeostatic plasticity Spontaneous neurotransmission +6

Inflammatory cytokines, cortisol, and anhedonia in patients with treatment-resistant depression after consecutive infusions of low-dose esketamine.

European Archives of Psychiatry and Clinical Neuroscience September 28, 2024 Yue Wang, Qiongyao Yang, Chuanchuan Chen et al. 10 citations

Anhedonia, defined as a significant loss of interest or pleasure, is one of the core symptoms of treatment- resistant depression (TRD) and is often associated with poor prognosis. This article primarily investigates the changes in anhedonia symptoms, inflammatory markers, and cortisol levels in TRD patients after low-dose esketamine treatments. A total of sixty patients with TRD were enrolled...

DOI: 10.1007/s00406-024-01913-w Full text Esketamine Anhedonia Cortisol Inflammatory cytokines +5

Double bookkeeping in schizophrenia spectrum disorder: an empirical-phenomenological study.

European Archives of Psychiatry and Clinical Neuroscience September 1, 2024 Helene Stephensen, Annick Urfer-Parnas, Josef Parnas 28 citations

Double bookkeeping is a term introduced by Eugen Bleuler to describe a fundamental feature of schizophrenia where psychotic reality can exist side by side with shared reality even when these realities seem mutually exclusive. Despite increasing theoretical interest in this phenomenon over the recent years, there are no empirical studies addressing this issue. We have, therefore, conducted a...

DOI: 10.1007/s00406-023-01609-7 Full text Phenomenology Double bookkeeping Insight Psychosis +2

Advancing past ketamine: emerging glutamatergic compounds for the treatment of depression.

European Archives of Psychiatry and Clinical Neuroscience August 29, 2024 Florian Freudenberg, Christine Reif-Leonhard, Andreas Reif 10 citations

Changes in glutamatergic neuroplasticity has been proposed as one of the core mechanisms underlying the pathophysiology of depression. In consequence components of the glutamatergic synapse have been explored as potential targets for antidepressant treatment. The rapid antidepressant effect of the NMDA receptor antagonist ketamine and subsequent approval of its S-enantiomer (i.e. esketamine),...

DOI: 10.1007/s00406-024-01875-z Full text Major depressive disorder Ampa Nmda Rapid acting antidepressant +7

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