Background: The therapeutic options for neurobehavioral disorders are still limited, and in many cases, they lack a satisfactory balance between efficacy and side effects. Objective: This work aims to review current evidence regarding the potential contribution of psychedelics and hallucinogens to the discovery of new drugs for treating different psychiatric disorders. Discussion:...
People have been using hallucinogens for thousands of years and interest in these substances has grown in recent years. The aim of this study was to determine the basic socio-demographic data, preferences, experiences, and attitudes associated with hallucinogen use in Slovakia. A cross-sectional research design was used whereby an online survey included participants who had had at least one...
Depression is a chronic psychiatric illness that causes deep sadness and a strong feeling of hopelessness. In this sense, new therapies are being approached. Ayahuasca tea is an example, a drink made from the vine of the Banisteriopsis caapi.and the leaves of Psycotria viridis often used in religious rituals such as santo-daime, and which has also been shown to be effective in the treatment of...
Ethnopharmacological relevanceAyahuasca, a psychoactive beverage prepared from Banisteriopsis caapi and Psychotria viridis, is originally used by Amazon-based indigenous and mestizo groups for medicinal and ritualistic purposes. Nowadays, ayahuasca is used in religious and shamanic contexts worldwide, and preliminary evidence from preclinical and observational studies suggests therapeutic...
The interest in psychedelic substances as potential treatments for psychiatric disorders is increasing. The β-carboline harmine, an Ayahuasca component, presents hallucinogenic and antidepressant effects. Although Ayuahuasca-and consequently harmine-is usually consumed in rituals, the role of social contexts in the behavioral effects of harmine has not been investigated yet. In this sense,...
BackgroundAyahuasca is a psychotropic drink made from the Amazonian vine Banisteriopsis caapi. Active components include beta-carboline alkaloids and the hallucinogen N-N-dimethyltryptamine (DMT). This review aimed to identify and summarize the literature on the safety and effectiveness of ayahuasca among recreational users.MethodA comprehensive literature search was done on November 1, 2019 in...
During the last decades, ayahuasca gained much popularity among non-Indigenous and out-of-Amazonia based populations. In popular culture, it has been advertised as a natural remedy that was discovered by Indigenous peoples ante millennia and that has been used for shamanic healing of all kinds of ailments. This “neo-shamanic,” and often recreational, use of ayahuasca, however, has to be...
Algı ve durum değişikliğine neden olan halüsinojenik bileşikler içeren psikoaktif bitkilerin binlerce yıldır yerli halklar tarafından ritüellerde kullanıldığı bilinmektedir. Bu bağlamda psikoaktif bir içecek olan ayahuasca eski zamanlardan beri Amazon ormanlarında yaşayan çok sayıda yerli kabilenin dinî, tıbbî, sosyal ve sanatsal yaşamlarında önemli bir yere sahiptir. Ayahuascayı insanın ruhsal...
Brazilian Journal of Natural SciencesOctober 12, 2021Beatriz Souza Silva, Giovanna Pereira Lima, Isabela Rodrigues Alencar Dos Santos et al.2 citations
Doença comum atualmente, a depressão, quando diagnosticada, é tratada com fármacos antidepressivos, sendo os inibidores seletivos da receptação de serotonina (ISRSs) considerados os de primeira escolha. Tanto esta quanto as demais classes de antidepressivos costumam apresentar efeitos adversos, que muitas vezes levam ao abandono do tratamento pelo paciente. Um outro desafio no tratamento da...
Background: Naturalistic and placebo-controlled studies have suggested that ayahuasca, a traditional Amazonian beverage, could be helpful in the treatment of psychopathologies like depression and anxiety disorders by changing otherwise disturbed cognitive and emotional processes. To better understand its full therapeutic potential, one way is to study the effects on processes like flexible...
Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. Scientific studies with ayahuasca are rapidly increasing due to its subjective effects and therapeutic potential. Although ayahuasca is traditionally used in its liquid presentation, lyophilized (freeze-dried) ayahuasca is often used in scientific...
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of four individual plants, in a commercial mixture and in four mixtures of two individual plants used in the preparation of Ayahuasca. The...
ACTA GeográficaSeptember 8, 2021Julien Marius Reis Thévenin, Talita Benaion Bezerra Thevenin, Carlos Teodoro José Hugueney Irigaray2 citations
A relação que os grupos sociais estabelecem com a natureza está permeada pelos sistemas de representações e ideias, principalmente, os religiosos e filosóficos. Contudo, a trajetória percorrida pela sociedade urbano-industrial, baseada no lucro, tem conduzido a sérios problemas ambientais, dentre eles o desflorestamento da Amazônia. É na busca por relações que atribuam valores não econômicos à...
Ayahuasca is a psychotropic plant-based tea from the Amazon. Its ceremonial use for therapeutic and spiritual purposes has become increasingly common and stands to escalate based on current policy initiatives in some countries. As ceremonial ayahuasca use spreads there is a need to understand, from various perspectives, how best to improve outcomes and minimize potential harms. Clinicians and...
O artigo apresenta algumas reflexões sobre como a Doutrina do Santo Daime incorpora no seu eixo doutrinário fundamentalmente elementos do xamanismo amazônico e do cristianismo popular. Essa doutrina fundada por Raimundo Irineu Serra em 1930, no interior do Acre, faz uso da ayahuasca, uma bebida considerada sagrada usada há milhares de anos pelos povos indígenas da região da floresta amazônica....
The ritualistic use of ayahuasca can induce a feeling of unity and harmony among group members. However, such depoliticized feelings can come in the service of a destructive political status quo in which Palestinians are marginalized. Through 31 in-depth interviews of Israelis and Palestinians who drink ayahuasca together, and through participatory observations, such rituals were examined. In...
Abstract Background and aims There is a growing body of evidence suggesting that the psychedelic plant tea, ayahuasca, holds therapeutic potential. Uthaug et al. (2018) demonstrated that a single dose of ayahuasca improved mental health sub-acutely and 4-weeks post-ceremony in healthy participants. The present study aimed to replicate and extend these findings. A first objective was to assess...
Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral sensitization (EIBS). Swiss mice received 2.2 g/kg ethanol or saline IP injections every other day across nine days (D1, D3, D5, D7, and D9),...
Abstract Objective Ayahuasca is a psychedelic brew that originated in the Amazon basin. The psychological effects of this drug are becoming better understood due to the growing research interest in identifying new potential therapeutic agents for the treatment of emotion dysregulation and other disorders. Previous studies suggest that ayahuasca enhances mindfulness‐related capacities...
Rationale: Previous studies with the serotonergic hallucinogens LSD and psilocybin showed that these drugs induced changes in personality traits, such as increases in Openness. However, results are inconsistent, and the effects of ayahuasca on personality were never investigated in a controlled trial. Objectives: To assess the effects of ayahuasca on personality in two randomized,...