CIENCIAMATRIAAugust 1, 2025Daniel Santiago Rivera-Rosero, Tannia Cristina Poveda-Morales
El objetivo de la presente investigación fue realizar un estudio de la bebida ancestral ayahuasca (Banisteriopsis CAAPI) para la elaboración de un menú gastronómico. La metodología investigativa descriptiva y explicativa, mediante los métodos analítico sintético, histórico lógico, y análisis documental. Los resultados y análisis realizados y los alimentos elaborados, queda en constancia el...
Ayahuasca is a traditional Amazonian brew composed primarily of Banisteriopsis caapi and Psychotria viridis, drawing increasing interest for its psychedelic effects and potential therapeutic applications. Its pharmacological action is based on the synergistic combination of β-carbolines (harmine, tetrahydroharmine, and harmaline), which act as reversible inhibitors of monoamine oxidase A...
Abstract Ayahuasca is a psychedelic brew used for centuries in religious rituals by indigenous cultures. Recent studies suggest its potential to reduce depression and anxiety and as an alternative for treating ethanol and tobacco use disorders. However, research on its impact on cocaine use disorder remains limited. We investigated the effects of ayahuasca on the reinstatement of...
Pain is a protective mechanism that can be classified into acute and chronic types. Ayahuasca is a psychoactive brew rich in dimethyltryptamine or DMT (a 5-HT2A receptor agonist), and harmine (a monoamine-oxidase (MAO) inhibitor) used for religious and therapeutic purposes. Previous preclinical and anecdotal evidence suggests that ayahuasca and its compounds have antinociceptive and...
Depression is a common disorder around the world, according to the WHO (World Health Organization) about 350 million people worldwide suffer from the disease, a number that is growing every day. Brazil is the second country in the Americas with the highest number of depressive people, where about 5.8% of the population has been diagnosed with the pathology. Depression is a chronic and recurrent...
Este texto tem como propósito compartilhar uma trajetória pessoal do que tem sido uma jornada de aprofundamento espiritual que começou quando participei, pela primeira vez, de uma cerimônia com ayahuasca, em 2015. Isso lançou o autoconhecimento como uma necessidade urgente em mim, em vez das angústias existenciais que permeavam minha vida. Desde então, o uso ritual da ayahuasca tornou-se uma...
Abstract Background : Military veterans are at risk of various mental health conditions, with profound implications for post‐deployment quality of life. Current treatment options encounter high dropout rates and non‐responsiveness, and overlook the importance of community building in veterans’ holistic recovery. Preliminary research suggests psychedelics offer therapeutic benefits for...
PsychoactivesJune 25, 2025Guillermo Escobar-Cornejo, Fernando P. Cárdenas, Diego Torres et al.
Objective: To provide a state of the art on the use, role, and function of music during psychedelic-assisted therapy (PAT) with ayahuasca. Introduction: Ayahuasca is a medicinal brew with psychoactive qualities used by indigenous communities throughout the Amazon region, and music is deemed crucial during ayahuasca experiences. In PAT, music forms part of the set and setting, but it lacks...
Background: Mindfulness and compassion are therapeutically relevant and can be increased through different forms of meditation practices. However, meditation practice needs time and commitment. These resources are often limited in patients with mood disorders. Therefore, efficacious remedies that increase mindfulness and compassion could provide therapeutic options. This study aimed to...
Mindfulness and compassion are therapeutically relevant and can be increased through different forms of meditation practices. However, meditation practice needs time and commitment. These resources are often limited in patients with mood disorders. Therefore, efficacious remedies that increase mindfulness and compassion could provide therapeutic options. This study aimed to investigate the...
The psychoactive brew Ayahuasca has a central role in the traditional medicines of the indigenous people of the Amazon basin and in recent decades has generated significant research interest among the academic community along with the revival of psychedelic medicine. The therapeutic community Takiwasi, located in Peru, leads this movement in its dedication to treatment of substance use...
Sexual and gender minority (SGM) individuals experience disproportionately high rates of depression, anxiety, trauma, and discrimination, yet remain underrepresented in psychedelic research. This prospective, naturalistic study explored the impact of an ayahuasca retreat experience on mental health, quality of life, and spiritual well-being among SGM participants. Nineteen individuals attending...
Metabolic Brain DiseaseJune 11, 2025Daniel do Nascimento Sousa, Monique de Azevedo, Maria Lucília Santos et al.5 citations
Ayahuasca (Aya) is an Amazonian beverage traditionally used as medicine by Indigenous people in South America to treat various illnesses and have shown a potential to treat depression. This study aimed to investigate the antidepressant effects of fluoxetine, Aya and N, N dimethyl tryptamine (DMT), a component of the beverage, focusing on the modulation of inflammatory serum cytokine profiles...
Esta pesquisa aborda os cantos xamânicos tradicionais da etnia Huni Kuin/Kaxinawá (Acre) entoados nas cerimônias de ayahuasca (nixi pae) e presenciados pelo autor em espaços de vivências multiétnicas. Busca-se compreender a organização, as funções e características de tais cantos, denominados huni meka, nesses rituais indígenas. Concomitantemente, investiga-se de que forma a cosmologia e a...
Full book as a PDF. Contents: 1. Introduction2. Ayahuasca in the treatment of bipolar disorder with psychotic features3. Ayahuasca in the treatment of chronic childhood sexual abuse in a religious community4. Indigenous ayahuasca ceremonies in the European context5. Touch and play — ’spiritual attacks’ in ayahuasca ceremonies6. The clinical trial as a ritual
Opioid-related overdose deaths have reached record high levels, and novel treatments for opioid use disorder (OUD) are needed. The three United States Food and Drug Administration (FDA)-approved medications for OUD function primarily at the mu-opioid receptor. While these remain the gold-standard treatment for OUD, they have shortcomings and treatment options separate from the opioid receptor...
Psychedelics are known to profoundly alter perception and self-referential processing, yet their specific effects on face recognition -particularly with regard to the recognition of face familiarity-remain underexplored. This study investigates the effects of an ayahuasca-inspired novel DMT/HAR (N,N-dimethyltryptamine/Harmine) formulation and Harmine alone on face recognition and...
This study examined patient perspectives on psilocybin therapy, specifically their acceptance and views on the therapeutic benefits of both hallucinogenic and non-hallucinogenic forms. A cross-sectional survey was conducted among psychiatric patients aged 18-65 at a community mental health center, assessing their attitudes, knowledge, and acceptance of psilocybin therapy. In total, 62.4% of the...
O objetivo do presente estudo é compreender como o contexto de uso exerce influência na experiência psicodélica e no potencial terapêutico da Ayahuasca. Para isso consistiu-se numa revisão integrativa de literatura. Foi realizada uma busca dos descritores Banisteriopsis, “Ayahuasca” e “daime” nas bases de dados: Scientific Eletronic Library (Scielo); Medical Publisher (PUBMED); Literatura...
Introdução. Ayahuasca é uma bebida indígena utilizada originalmente em rituais xamânicos. O chá é composto por duas plantas, a Psychotria viridis, conhecida como Chacrona, que contém um potente alcaloide alucinógeno denominado DMT (N,N-dimetiltriptamina), e a Banisteriopsis caapi, conhecida como cipó Mariri, que possui alcalóides β-carbolínicos. Objetivo. Aplicar um questionário online em grupo...