Psychedelics hold promise for psychiatry, yet clinical translation remains premature. Addressing the challenges of psychedelics in psychiatry requires advances in mechanistic study, clinical implementation, regulatory governance and public discourse in parallel.
Psilocybin, a psychedelic drug with reported anxiolytic and antidepressant potential, is rapidly metabolized to its active metabolite psilocin. However, a lack of adequate toxicity studies and tissue distribution studies currently restricts its development and application. This study combined behavioral assays in zebrafish with desorption electrospray ionization mass spectrometry imaging...
The Cartesian meditations on first philosophy intended to demonstrate the existence of God. Wittgenstein’s private language argument is regarded as an attack on Cartesian dualism through the investigation of “private language” by a paradigm of sensation. This article explores how the “private language argument” bears on the Cartesian theory of mind. The mind and the body are not distinct and...
The educational philosophy of the Nuns’ Buddhist Academy at Pushou Monastery, Mount Wutai, is based on the principles of “Hua Yan as the foundation, precepts as the practice, and Pure Land as the destination.” This philosophy draws upon Buddhist scriptures, integrating descriptions of the Pure Land practice found in the Avatamsaka Sūtra and the Amitābha Sūtra. This approach translates the...
The 5-hydroxytryptamine 2A receptor (5-HT2AR) is one of the key targets in the development of novel antidepressants. To develop new antidepressants targeting the 5-HT2A receptor, this study established a high-throughput screening method for drugs targeting the 5-HT2A receptor based on the principle of detecting calcium flux signals. The immunofluorescence assay and western blotting were...
Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could provide rapid improvement for individuals with emotional disorders. A practice-oriented randomized controlled trial was conducted on a sample of 302 patients with emotional...
This study aimed to observe the effect of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoidectomy. Eighty children scheduled for tonsillectomy and adenoidectomy were randomly divided into two groups using a random number table: an esketamine group (S-ketamine group, N.=40) and a control group (control group, N.=40). The primary outcome...
PURPOSE OF REVIEW To explore the convergent downstream pathways of ketamine and rapastinel and drive further development of identification for following generational rapid-acting antidepressants in the synaptic process. RECENT FINDINGS Ketamine is an NMDAR antagonist and is proven effective in depression for the rapid and sustained antidepressant response, while rapastinel is an NMDAR positive...
We report a case in which sublingual buprenorphine was used to help transition a patient off intravenous (IV) opioid analgesics medications post-multiple abdominal procedures. Intravenous opioids are commonly used in inpatient surgical pain management for patients with severe pain who are unable to take oral medications. Typically, a short course of IV analgesics is used, followed by transition...
Objective: The present study investigated the ways in which dispositional mindfulness is related to posttraumatic stress disorder (PTSD) symptoms and job burnout among firefighters by considering the role of perceived social support. Method: A total of 409 Chinese firefighters completed the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders, fifth edition, the Maslach...