Background: Major depressive disorder (MDD) is a severe mental illness associated with severe clinical consequences and substantial societal burden. It’s characterized by immune-inflammatory dysregulation and immune sensitization. Objective: To determine whether in vitro ketamine attenuates phytohemagglutinin (PHA)/lipopolysaccharide (LPS)-induced immune sensitization in patients with MDD and...
Research SquareAugust 18, 2026Shenghuan Yang, Yan Lou, Tingting Chen et al.
preprint
Abstract Background: Patients with advanced cancer frequently experience multidimensional suffering,including psychological distress,existential distress,and concerns related to death and dying.Mindfulness-based interventions and existential healing interventions have increasingly been applied in palliative care;however,the current evidence regarding their integration,intervention...
BACKGROUND Patients undergoing peritoneal dialysis (PD) frequently experience anxiety and sleep disturbances.However, the comparative efficacy of psychological interventions on these symptoms remains unclear.AIM To compare the efficacy of mindfulness-based cognitive therapy (MBCT) and routine psychological support (PS) on anxiety symptoms and sleep quality in patients undergoing PD.METHODS This...
Objective: To evaluate the effect of mindfulness training in addition to essential psychological counseling on the clinical pregnancy rate in women undergoing frozen embryo transfer (FET), and to explore the potential mediating role of neuropsychological improvements. Methods and analysis: This study will be conducted as a single-center, parallel-group, open-label, exploratory randomized...
This study aims to explore the clinical efficacy of mindfulness-based stress reduction (MBSR) combined with ear triple therapy in improving blood pressure, symptoms, emotions, and other multidimensional conditions of young and middle-aged patients with hypertension. Using convenient sampling, young and middle-aged patients with hypertension who visited Jiangsu Provincial Hospital of Chinese...
Clinical ToxicologySeptember 15, 2025Zhifan He, Rui Tang, Min Feng et al.1 citation
Introduction Psychoactive Psilocybe spp. mushrooms pose significant public health risks. We report a cluster of Psilocybe keralensis poisonings in Chengdu, China, highlighting its unique clinical features and cardiovascular complications.Case Series Four patients ingested 16–90 g of wild mushrooms (misidentified as an edible species, but later molecularly confirmed as Psilocybe keralensis)....
3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a recreational drug under clinical investigation for the treatment of central nervous system disorders, including post-traumatic stress disorder. Chemical synthesis of MDMA mainly relies on the use of safrole and piperonal as starting materials. We report a novel strategy integrating bioconversion and biocatalysis in the bioproduction of MDMA...
Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include 'magic mushrooms' (Psilocybe spp.), plants used to prepare ayahuasca, and toads. The skin and parotid glands of certain toads accumulate a variety of specialized metabolites including toxic guanidine alkaloids, lipophilic alkaloids, poisonous...
Abstract Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include ‘magic mushrooms’, plants used to prepare ahayuasca, and toads. Owing to the occurrence of indolethylamines such as N,N-dimethyltryptamine, toad skin and parotid gland preparations have a history of ceremonial use, yet their biosynthesis...
Background: Mindfulness meditation is beneficial to mitigate the negative effects of the coronavirus disease 2019 (COVID-19) pandemic in the general population, but no study examined such meditation in the COVID-19 patients themselves. Aim: To explore the short-term efficacy of mindfulness meditation in alleviating psychological distress and sleep disorders in patients with COVID-19. Methods:...
Purpose: Although patients with primary and metastatic brain tumors (BT) and their partners are at risk of experiencing high symptom burden, they are often excluded from psychosocial intervention studies. Thus, we sought to examine the feasibility and preliminary efficacy of a couple-based meditation (CBM) program targeting symptom and well-being outcomes. Methods: Couples completed baseline...
Dynamically assessing the level of consciousness is still challenging during anesthesia. With the help of Electroencephalography (EEG), the human brain electric activity can be noninvasively measured at high temporal resolution. Several typical quasi-stable states are introduced to represent the oscillation of the global scalp electric field. These so-called microstates reflect spatiotemporal...
Aim: To explore what the women experience during their first IVF-ET treatment while participating a mindfulness-based intervention for IVF-ET (MBII), and how they use it to enhance their infertility-related quality of life (QoL). Design: Qualitative exploratory design. Methods: As part of a larger multimethod study, this study shares the description from 38 IVF-ET women. We conducted...
Abstract Background Postpartum depression (PPD) is a common mental disease in postpartum women, which has received more and more attention in society. Ketamine has been confirmed for its rapid antidepressant effect in women with PPD. We speculate that esketamine, an enantiomer of ketamine, pretreatment during cesarean can also reduce the incidence of PPD. Methods All the parturients enrolled in...