Nature Structural & Molecular Biology
June 22, 2026
Qianru Jiang, Jianming Han, Eve Fine et al.
Ketamine offers rapid relief for treatment-resistant depression and severe pain in the clinic, providing immediate benefits that traditional medications often fail to deliver. While its antagonistic action at the N-methyl-D-aspartate receptor (NMDAR) is a key mechanism, ketamine's dual nature as both a promising treatment and a drug with abuse potential suggests its therapeutic effects extend...
Journal of neurosurgical anesthesiology
June 15, 2026
Yi Liang, Wanning Yang, Xinxin Wang et al.
Effective treatments for prolonged disorders of consciousness (pDoC) remain limited. Grounded in the entropic brain hypothesis-that psychedelic agents facilitate consciousness recovery by increasing brain complexity-this study investigated esketamine, a nonclassical psychedelic drug, and its effects on electroencephalographic (EEG) neurophysiological metrics in pDoC patients. In this...
bioRxiv : the preprint server for biology
May 11, 2026
Jared Plotkin, Elaine Zhu, Mélanie Druart et al.
Psychedelics produce long-lasting effects, but their circuit mechanisms remain unclear. Here we show that, in rats, a single dose of lysergic acid diethylamide (LSD) persistently reduces pain affect. This effect is recapitulated by local administration in the anterior cingulate cortex (ACC), but not primary somatosensory cortex. Neuropixels recordings reveal that LSD suppresses stimulus-evoked...
Frontiers in Psychology
2026
Zhongfu Zhang, Qingqin Xu, Jing Wang et al.
Chronic tinnitus is often accompanied by considerable psychological burden, including anxiety, depression, and impaired quality of life. Mindfulness-based therapy has attracted growing attention as a potential psychological intervention for tinnitus management. This narrative review examines the current literature on the rationale, clinical application, reported efficacy, limitations, and...
Multiple sclerosis and related disorders
November 1, 2025
Yang Yang, Xinyi Duan, Jing Wang et al.
1 citation
Ofatumumab, a fully humanized anti-CD20 monoclonal antibody, is the only highly effective disease modifying therapy (DMT) approved for the treatment of relapsing multiple sclerosis (RMS) in China up to data. Real-world data are necessary to investigate the factors for switching from oral DMTs and to assess the effectiveness and safety of ofatumumab in the Chinese MS population. We conducted a...
Religions
October 3, 2025
Y. Li, Yi Zhang, Jing Wang
The educational philosophy of the Nuns’ Buddhist Academy at Pushou Monastery, Mount Wutai, is based on the principles of “Hua Yan as the foundation, precepts as the practice, and Pure Land as the destination.” This philosophy draws upon Buddhist scriptures, integrating descriptions of the Pure Land practice found in the Avatamsaka Sūtra and the Amitābha Sūtra. This approach translates the...
Cureus
October 1, 2025
Xinmin Jiang, Minghui Zhang, Jiaqi Wang et al.
This meta-analysis was conducted to investigate the effect of mindfulness-based stress reduction (MBSR) on the treatment and improvement of traumatic stress disorder (PTSD). Up until February 6, 2025, PubMed, Web of Science, and Embase databases were searched for randomized controlled trials of MBSR-based treatment for PTSD patients. RevMan 5.4 software (The Cochrane Collaboration, London, UK)...
Neuroimage
July 18, 2025
Xin Wen, Yu Chang, Sijie Li et al.
1 citation
The search for neurophysiological markers of consciousness and their neural substrates remains a focal point in neuroscience research. The integrated information theory (IIT) provides a promising quantitative framework for consciousness assessment, but computational limitations of existing Φ estimation methods hinder an in-depth understanding of large-scale cortical integration. Here, we...
Frontiers in Pharmacology
2025
Jing Wang, Yulei Hao, Di Ma et al.
14 citations
The recreational abuse of addictive drugs poses considerable challenges to public health, leading to widespread neurotoxicity and neurological dysfunction. This review comprehensively examines the neurotoxic mechanisms, clinical manifestations, and treatment strategies associated with six commonly abused substances: methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide and...
Pain
September 1, 2024
Yang Zhou, Wanchen Sun, Yuxuan Fu et al.
9 citations
Moderate-to-severe acute postsurgical pain (APSP) can prolong the recovery and worsen the prognosis of patients who undergo spinal surgery. Esketamine and pregabalin may resolve APSP without causing hyperpathia or respiratory depression after surgery. However, there are other risks, such as dissociative symptoms. We designed a randomized controlled trial to investigate the effect of the...
Anesthesiology
May 1, 2024
Zhenhu Liang, Bo Tang, Yu Chang et al.
13 citations
Identifying the state-related "neural correlates of consciousness" for anesthetics-induced unconsciousness is challenging. Spatiotemporal complexity is a promising tool for investigating consciousness. The authors hypothesized that spatiotemporal complexity may serve as a state-related but not drug-related electroencephalography (EEG) indicator during an unconscious state induced by different...
CNS Neuroscience & Therapeutics
January 10, 2023
Jing Wang, Min Liang, Qing Shang et al.
23 citations
Abstract Aim Psilocin is an active metabolite form of psilocybin and exerts psychoactive effects. Recent studies suggest that psilocin may have regulatory effects on abuse drugs, but the mechanisms remain unclear. In this study, we want to explore the effects of psilocin on methamphetamine (METH)‐induced alterations of behavior in mice and its molecular mechanisms. Methods Acute METH...
Frontiers in Psychology
June 1, 2021
Dongjiao An, Changwei Wei, Jing Wang et al.
46 citations
Background There is growing interest in glutamatergic agents as a treatment for depression, especially intranasal ketamine, which has become a hot topic in recent years. We aim to assess the efficacy and safety of intranasal ketamine in the treatment of major depressive disorder (MDD), especially treatment-resistant depression (TRD). Methods We searched Medline, EMBASE, and the Cochrane Library...
Drug Design Development and Therapy
December 1, 2019
Jing Wang, Jie Huang, Shuang Yang et al.
214 citations
Purpose: To assess the pharmacokinetics and safety of pure S-ketamine (esketamine) in Chinese patients undergoing painless gastroscopy and evaluate the potential advantage of esketamine in clinical treatment compared with racemate ketamine hydrochloride injection. Patients and methods: A randomized, open-label, parallel-controlled, Phase I study was performed with 32 patients undergoing...
Scientific Reports
June 5, 2017
Ze-Min Xie, Xingming Wang, Ning Xu et al.
69 citations
Although pain is frequently accompanied with depression, little is known about the risk factors contributing to individual differences to the comorbidity of pain and depression. In this study, we examined whether cytokines and brain-derived neurotrophic factor (BDNF) might contribute to the individual differences in the development of neuropathic pain-induced depression. Rats were randomly...