Nature Communications
September 17, 2026
Huiqiong Li, Lingjie Tang, Jinfeng Zhang et al.
Classical psychedelics exert hallucinogenic and therapeutic effects primarily through activation of serotonin 2 A receptor (5-HT2AR), offering promise as transformative treatments for neuropsychiatric disorders. However, their concurrent activation of 5-HT2BR—associated with cardiac valvulopathy—raises serious safety concerns, underscoring the need for subtype-selective psychedelics. To address...
bioRxiv
August 12, 2026
Ru-Yi Cai, Yue-Qi Yang, Shang-Xuan Cai et al.
preprint
The endocannabinoid system modulates diverse physiological processes via two endogenous lipid ligands, 2-arachidonoylglycerol (2-AG) and anandamide (AEA); however, their specific spatiotemporal dynamics remain poorly understood owing to the lack of selective probes. Here, we developed GRAB2-AG2.0 and GRABAEA2.0, two genetically encoded fluorescent sensors that selectively detect 2-AG and AEA,...
Cell
August 1, 2026
Yating Wen, Lingjie Tang, Wenwen Duan et al.
Cancer remains a leading cause of morbidity and mortality worldwide. While classical psychedelics have been used clinically to treat cancer-associated psychiatric disorders, their impact on tumor progression is unclear. Here, we show that by targeting the serotonin receptor 5-HT2AR, lysergic acid diethylamide (LSD) enhances CD8+ T cell-mediated antitumor immunity and suppresses colorectal...
International Journal of Nursing Practice
November 2, 2025
Zhenwei Dai, Shu Jing, Dongxue Chen et al.
BACKGROUND: Chinese nursing students face mental health challenges, with mindfulness-based interventions (MBI) commonly utilized to mitigate these issues. Neurofeedback-assisted MBI (NF-MBI) might be a promising alternative. AIM: The study aims to explore the short- and long-term effectiveness of the NF-MBI and MBI in improving mental well-being among Chinese nursing students. METHODS: This...
Journal of Medicinal Chemistry
October 14, 2025
Rongyan Li, Hong Yan, Yujin Chen et al.
1 citation
Depression is primarily treated with selective serotonin reuptake inhibitors (SSRIs), which are limited by delayed onset of effects and low rates of remission. Recent studies showed that serotonergic psychedelics such as psilocybin can reduce depressive symptoms both rapidly and enduringly. Such effects have been associated with the activation of the serotonin 2A (5-HT2A) receptor in the...
BMC Public Health
February 19, 2025
Zhenwei Dai, Shu Jing, Yijin Wu et al.
10 citations
This study aims to evaluate the long-term impact of the six-week online mindfulness intervention course "Mindfulness Living With Challenge (MLWC)" on the mental health of undergraduate nursing students in Beijing, China, through a three-month follow-up. A three-month follow-up was conducted upon completion of the six-week MLWC course. Depression-Anxiety-Stress Scale (DASS-21), Chinese Short...
Nursing Open
July 1, 2024
Huan Wang, Zhenwei Dai, Shu Jing et al.
10 citations
To analyse the factorial structure and psychometric properties of the Chinese Short-Form Five Facets of Mindfulness Questionnaire (FFMQ-SF) among nursing students in the Chinese mainland. A cross-sectional study. A total of 240 undergraduate nursing students were recruited from a school of nursing in Beijing, China from 25 to 30 April 2021. FFMQ-SF and Depression-Anxiety-Stress Scale were used...
JAACAP open
August 29, 2023
Xinshu She, Lian Tong, Huan Wang et al.
Objective: To test the feasibility and effectiveness of a mindfulness-based intervention in rural-to-urban migrant Chinese children using trained community volunteers. Method: Migrant students ages 9 to 16 from 5 schools in Shanghai (N = 653) were randomly assigned to a mindfulness only group (n = 167), a mindfulness plus life skills group (n = 118), or a waitlist control group (n = 368). The...
Frontiers in Psychiatry
November 16, 2022
Zhenwei Dai, Shu Jing, Hao Wang et al.
Objective: To evaluate the effect of mindfulness intervention on improving mental health among undergraduate nursing students during the coronavirus disease 2019 (COVID-19) pandemic in China. Methods: An online mindfulness intervention course named Mindfulness Living With Challenge (MLWC) was developed by the research team, and a randomized controlled trial using MLWC among Chinese...
Science
January 27, 2022
Dongmei Cao, Jing Yu, Huan Wang et al.
306 citations
Drugs that target the human serotonin 2A receptor (5-HT 2A R) are used to treat neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use. Here, we present structures of 5-HT 2A R complexed with the psychedelic drugs psilocin (the active metabolite of psilocybin) and d -lysergic acid diethylamide (LSD), as well as the endogenous neurotransmitter serotonin and the...