Biochemical and Biophysical Research Communications

S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation.

Biochemical and Biophysical Research Communications July 8, 2025 Jiaxin Tian, Yanhong Xie, Sen Ye et al. 6 citations

The available therapeutic options for post-stroke depression patients are limited. Although SSRIs are the most commonly prescribed antidepressants, their slow onset of action and the higher risk of adverse effects or contraindications have led to an urgent need to develop fast-acting and highly specific antidepressants tailored to the needs of PSD patients. Therefore, ketamine has drawn...

DOI: 10.1016/j.bbrc.2025.151965 Full text S-ketamine Neuroinflammation Post-stroke depression psd Synaptic function +5

Crystal structure of an antibody specifically recognizing 3,4-methyl enedioxy methamphetamine through the epoxide moiety.

Biochemical and Biophysical Research Communications November 12, 2024 Geonho Cheon, Dahyun Hwang, Truc Chi Le et al. 2 citations

3,4-methylenedioxymethamphetamine (MDMA) or publicly known as "ecstasy" is a drug abuse substance. Since antibodies that detect MDMA typically also recognize its chemical analogue, methamphetamine (METH), we identified antibodies specifically recognizing MDMA, but not METH, named 1bB11 and 1bF12, using phage display. The crystal structure of 1bB11 in complex with MDMA was determined at 3.2 Å...

DOI: 10.1016/j.bbrc.2024.150607 Full text MDMA Crystal structure Epoxide moiety Meth +10

Adolescent administration of ketamine impairs excitatory synapse formation onto parvalbumin-positive GABAergic interneurons in mouse prefrontal cortex.

Biochemical and Biophysical Research Communications September 17, 2024 Jia-Wei Zhang, Hai-Qian Zhou, Zhen Zhu et al. 7 citations

Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, induces deficits in cognition and information processing following chronic abuse. Adolescent ketamine misuse represents a significant global public health issue; however, the neurodevelopmental mechanisms underlying this phenomenon remain largely elusive. This study investigated the long-term effects of sub-chronic ketamine (Ket)...

DOI: 10.1016/j.bbrc.2024.150272 Full text Ketamine Brain plasticity Adolescence Excitatory synapse +6

A mechanistic insight for the biosynthesis of N,N-dimethyltryptamine: An ONIOM theoretical approach.

Biochemical and Biophysical Research Communications October 20, 2023 Lucas Pinheiro Coutinho, Sérgio Ruschi Bergamachi Silva, Pedro de Lima-Neto et al. 3 citations

Psychoactive natural products are potent serotonergic agonists capable of modulating brain functions such as memory and cognition. These substances have shown therapeutic potential for treating various mental disorders. The fact that N,N-dimethyltryptamine (DMT) is produced endogenously in several plants and animals, including humans, makes it particularly attractive. As an amino acid-derived...

DOI: 10.1016/j.bbrc.2023.08.043 Full text Mechanism N,N-Dimethyltryptamine DMT Oniom Psychoactives +4

Integrated information theory does not make plant consciousness more convincing.

Biochemical and Biophysical Research Communications July 30, 2021 Jon Mallatt, Lincoln Taiz, Andreas Draguhn et al.

It has been proposed by some plant scientists that plants are cognitive and conscious organisms, although this is a minority view. Here we present a brief summary of some of the arguments against this view, followed by a critique of an article in this same issue of Biochemical and Biophysical Research Communications by Calvo, Baluska, and Trewavas (2020) that cites Integrated Information Theory...

DOI: 10.1016/j.bbrc.2021.01.022 Full text Cellular consciousness Neurobiological naturalism Plant consciousness Plant neurobiology

Integrated information as a possible basis for plant consciousness.

Biochemical and Biophysical Research Communications July 30, 2021 Paco Calvo, František Baluška, Anthony Trewavas

It is commonly assumed that plants do not possess consciousness. Since the criterion for this assumption is usually human consciousness this assumption represents a top down attitude. It is obvious that plants are not animals and using animal criteria of consciousness will lead to its rejection in plants. However using a bottom up evolutionary approach and a leading theory of consciousness,...

DOI: 10.1016/j.bbrc.2020.10.022 Full text Awareness Bioelectrical fields Meristems Plant consciousness +1