Schizophrenia Research - The Consciousness Library

Subjective space and time experience in schizophrenia spectrum disorders and mood disorders: Psychometric properties and clinical correlates of the semi-structured STEP interview.

Schizophrenia Research July 23, 2026 J. Daub, S. Volkmer, D. Altinok et al.

BACKGROUND Altered experiences of space and time are core features of schizophrenia spectrum disorders (SSD) and mood disorders (MOD). In this study, we investigated whether patients with SSD and MOD exhibit shared or distinct patterns of subjective spatiotemporal experience. METHODS We examined 62 ICD-11 patients (33 SSD, 29 MOD) using the Scale for Space and Time Experience in Psychosis...

DOI: 10.1016/j.schres.2026.07.014

Increased brain VDAC1 protein levels correlate with behavioural performance in a ketamine murine model of schizophrenia and are attenuated by the mGluR2 modulator JNJ-46356479.

Schizophrenia Research June 16, 2026 David Olivares-Berjaga, Natàlia Rodríguez, Albert Martínez-pinteño et al.

Schizophrenia (SZ) is a neurodevelopmental disorder involving excitatory/inhibitory imbalance and apoptotic dysregulation. VDAC1, a voltage-dependent anion channel protein located in the mitochondrial outer membrane, plays a pivotal role in mitochondria-mediated apoptosis. However, its involvement in SZ remains underexplored. This study aimed to investigate VDAC1 protein levels in the...

DOI: 10.1016/j.schres.2026.06.010 Full text Ketamine Apoptosis Jnj-46356479 Murine model +1

Why is it hard to assess thought disorder? Clarifying the third domain of psychosis.

Schizophrenia Research June 1, 2026 L Palaniyappan, Vanteemar S Sreeraj, Ganesan Venkatasubramanian et al. 5 citations

Formal Thought Disorder (FTD) presents psychiatry's central paradox: it is one of the robust predictors of poor outcomes and polygenic risk in psychosis yet remains poorly defined and rarely measured clinically. We systematically reviewed 50 years of FTD assessment (16 rating scales, 32 factor analyses) to understand this paradox. Research to date has implicitly treated FTD as a natural kind, a...

DOI: 10.1016/j.schres.2026.02.018 Full text Phenomenology Cognition Disorganization Measurement +4

From substance-induced psychosis to schizophrenia: Predictors of treatment response and transition to chronic psychotic illness-A systematic review.

Schizophrenia Research March 24, 2026 Valerio Ricci, Stefania Chiappini, Giovanni Martinotti et al.

Substance-induced psychotic disorders (SIPDs) present significant clinical challenges with variable outcomes. While some patients achieve complete remission following substance cessation, others develop persistent symptoms requiring extended intervention. Understanding treatment response predictors is critical for optimizing clinical management and prognostic accuracy. Following PRISMA...

DOI: 10.1016/j.schres.2026.02.022 Full text Antipsychotic medication Cannabis psychosis Prognosis Remission predictors +3

Psychedelics for treatment of negative symptoms and depressive symptoms in schizophrenia spectrum disorder: A narrative review

Schizophrenia Research March 13, 2026 Michel Sabé, Paul Grof, Nathan Sackett et al. 1 citation

Serotonergic psychedelics are re-emerging as therapeutic candidates across psychiatry, particularly for treatment-resistant depression. Their rapid and sustained antidepressant effects, alongside evidence for neuroplastic, dopaminergic, and glutamatergic modulation, have prompted interest in whether they could address depressive and negative symptoms in schizophrenia spectrum disorders (SSDs)....

DOI: 10.1016/j.schres.2026.03.003

Machine learning and graph-based connectivity metrics identify language disruption in psychosis: Novel insights from dream reports in an Italian cohort

Schizophrenia Research October 20, 2025 Elena Camon, Stefano Masier, Natália Bezerra Mota et al.

Language disorganization is a hallmark of psychosis which has traditionally been assessed through clinical interviews and standardized scales. Recent advances in Natural Language Processing (NLP) and graph theory provide innovative, objective methodologies to analyze language production in psychosis. In particular, dream reports, as a unique form of narrative, offer a valuable lens through...

DOI: 10.1016/j.schres.2025.10.017 Psychosis Naive bayes classifier Classifier uml Random forest +10

Effects of mindfulness- and acceptance-based interventions for individuals with schizophrenia spectrum disorders: A systematic meta-review.

Schizophrenia Research July 1, 2025 Antonia Meinhart, Annika Schmueser, Steffen Moritz et al. 4 citations

Mindfulness- and acceptance-based interventions (MBIs/ABIs) for persons with schizophrenia spectrum disorders (SSD) aim to cultivate purposeful attention, mind-body awareness, and targeted action-taking. This systematic meta-review assessed the current body of evidence regarding the effects of MBIs/ABIs for SSD symptoms. The study was registered with PROSPERO (CRD42024535284) on June 3, 2024....

DOI: 10.1016/j.schres.2025.03.040 Full text Mindfulness Act Acceptance Mbi +3

Pre-reflective and reflective abnormalities in cortical midline structures in schizophrenia.

Schizophrenia Research June 2, 2025 Maria Chiara Piani, Martin Jandl, Thomas Koenig et al. 3 citations

Self-disorders (SDs), central features of schizophrenia spectrum disorders, primarily affect the pre-reflective sense of self, the fundamental experience of existing as a conscious subject. This disruption also impacts reflective self-consciousness. This study aims to further explore the neural correlates of self-disorders in individuals with schizophrenia spectrum disorders by using a...

DOI: 10.1016/j.schres.2025.05.024 Full text Frontopolar cortex Basic self-experience Pre-reflective self-disorders Those with schizophrenia +5

Cannabidiol reverses myeloperoxidase hyperactivity in the prefrontal cortex and striatum, and reduces protein carbonyls in the hippocampus in a ketamine-induced schizophrenia rat model.

Schizophrenia Research April 1, 2025 Sofia de Almeida Queiroz, Linério Ribeiro de Novais Junior, Anita Beatriz Pacheco de Carvalho et al. 2 citations

Schizophrenia (SCZ) has limited treatment options, often with significant side effects. Cannabidiol (CBD), a non-euphoric phytocannabinoid, has shown potential as a novel therapeutic option in SCZ due to antipsychotic-like, anti-inflammatory, and antioxidant properties. We compared the therapeutic effects of CBD and risperidone (RISP) in a rat model of SCZ induced by sub-chronic ketamine (KET),...

DOI: 10.1016/j.schres.2025.03.031 Full text Cannabidiol Ketamine Rats Risperidone +4

Ontogenesis of self-disorders in the schizophrenia spectrum: A phenomenological neuro-developmental model.

Schizophrenia Research October 1, 2024 Michele Poletti, Andrea Raballo 10 citations

The concept of basic Self-disorders (SD) captures the experiential aspects associated with vulnerability to schizophrenia spectrum disorders (SSD). SD emerge prior to, and constitute the underlying structure for, the emergence of major diagnostic symptoms, including positive psychotic ones. SD are also detectable in populations with familial risk for SSD. This paper proposes a two-stage...

DOI: 10.1016/j.schres.2024.08.007 Full text Corollary discharge Feeling of agency Feeling of ownership Minimal self +3

Ketamine for catatonia: A novel treatment for an old clinical challenge? A systematic review of the evidence.

Schizophrenia Research September 1, 2024 Ana Teresa Caliman-Fontes, Flávia Vieira, Gustavo C. Leal et al. 7 citations

Catatonia, documented since the 19th century, remains a significant challenge in terms of recognition and treatment. Over the last two decades, ketamine has brought new perspectives to psychiatry, sparking widespread interest. Concurrently, catatonia has attracted heightened scientific attention. Preliminary evidence suggests the therapeutic potential of ketamine for catatonia. We...

DOI: 10.1016/j.schres.2024.07.055 Full text Esketamine Mental-health Psychiatric-treatment Ketamine-therapy +2

The phenomenological nature of schizophrenia and disorder of selfhood.

Schizophrenia Research August 1, 2024 Josef Parnas, Karl Erik Sandsten 17 citations

Schizophrenia continues its resistance to the pathogenetic understanding. We believe that one of the reasons is an oblivion of schizophrenia's characteristic Gestalt expressive of its psychopathological structure. In this article we argue for a crucial role of disorders of selfhood in the constitution of this Gestalt. First, we present a phenomenological account of the self. This is followed by...

DOI: 10.1016/j.schres.2024.06.032 Full text Phenomenology Psychopathology Schizophrenia Self-disorder

Schizophrenia and the bodily self.

Schizophrenia Research July 1, 2024 Vittorio Gallese, Martina Ardizzi, Francesca Ferroni 18 citations

Despite the historically consolidated psychopathological perspective, on the one hand, contemporary organicistic psychiatry often highlights abnormalities in neurotransmitter systems like dysregulation of dopamine transmission, neural circuitry, and genetic factors as key contributors to schizophrenia. Neuroscience, on the other, has so far almost entirely neglected the first-person...

DOI: 10.1016/j.schres.2024.05.014 Full text Bodily self Embodied simulation Multisensory integration Schizophrenia +1

Phenomenology of auditory verbal hallucination in schizophrenia: An erroneous perception or something else?

Schizophrenia Research March 1, 2024 Josef Parnas, Janne-Elin Yttri, Annick Urfer-Parnas 28 citations

This study presents phenomenological features of auditory verbal hallucinations (AVH) in schizophrenia and associated anomalies of experience. The purpose is to compare the lived experience of AVH to the official definition of hallucinations as a perception without object. Furthermore, we wish to explore the clinical and research implication of the phenomenological approach to AVH. Our...

DOI: 10.1016/j.schres.2023.03.045 Full text Phenomenology Auditory verbal hallucination Double bookkeeping Perception +1

Anomalies of imagination and development of psychosis: A phenomenological account.

Schizophrenia Research February 1, 2024 Andreas Rosén Rasmussen 8 citations

In 20th century psychiatry, various disturbances of imagination were discussed in the context of schizophrenia. Today, these notions have almost completely vanished from mainstream psychopathology. However, recent work has suggested that specific phenomena within this area have a relevance for differential diagnosis and early detection of psychosis. This paper first provides an overview of 20th...

DOI: 10.1016/j.schres.2023.12.024 Full text Phenomenology Mental imagery Schizophrenia Schizotypal disorder +2

Mindfulness-based interventions for patients with schizophrenia spectrum disorders: A systematic review of the literature.

Schizophrenia Research February 1, 2024 Michel Sabé, Raoul Kohler, Natacha Perez et al.

Mindfulness-based interventions (MBIs) have emerged as secular practices, including elements of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT). While MBIs have been widely adopted for physical and mental illness, only a few available programs are explicitly adapted for psychosis. However, previous reviews have reported the vital heterogeneity regarding...

DOI: 10.1016/j.schres.2023.12.011 Full text Mbct Mbsr Meditation Mbis +2

Spatiotemporal Psychopathology - An integrated brain-mind approach and catatonia.

Schizophrenia Research 2024 Georg Northoff, Dusan Hirjak

Catatonia is featured by complex symptoms combining motor, affective and behavioral phenomena as well as by its syndrome character with trans-diagnostic occurrence. It paradigmatically shows the limits of current forms of psychopathology like affective and cognitive approaches with respect to both clinical symptoms and brain mechanisms. We therefore suggest Spatiotemporal Psychopathology (STPP)...

DOI: 10.1016/j.schres.2022.10.006 Full text Brain topography Catatonia Dynamic Experience +2

Syntactic complexity of spoken language in the diagnosis of schizophrenia: A probabilistic Bayes network model.

Schizophrenia Research September 1, 2023 Angelica M Silva, Roberto Limongi, Michael Mackinley et al. 49 citations

In the clinical linguistics of schizophrenia, syntactic complexity has received much attention. In this study, we address whether syntactic complexity deteriorates within the six months following the first episode of psychosis in those who develop a diagnosis of schizophrenia. We collected data from a cohort of twenty-six first-episode psychosis and 12 healthy control subjects using the Thought...

DOI: 10.1016/j.schres.2022.06.011 Full text Early intervention Longitudinal Progressive Speech +1

Cannabis use and attenuated positive and negative symptoms in youth at clinical high risk for psychosis.

Schizophrenia Research August 25, 2022 Olga Santesteban-Echarri, Lu Liu, Madeline Miller et al.

Cannabis use is more prevalent among youth at clinical high-risk (CHR) for psychosis than healthy controls (HC). There is mixed evidence as to whether cannabis use is associated with increased severity of attenuated psychotic symptoms (APS) or whether current cannabis use is associated with the transition to psychosis. This study aims to assess cannabis use differences between CHR youth and HC...

DOI: 10.1016/j.schres.2022.08.005 Full text

What is obsession? Differentiating obsessive-compulsive disorder and the schizophrenia spectrum.

Schizophrenia Research May 1, 2022 Andreas Rosén Rasmussen, Josef Parnas

Obsessive-compulsive symptoms are frequent in schizophrenia-spectrum disorders and often cause differential diagnostic challenges, especially in first-contact patients. Drawing upon phenomenology of cognition, we critically review classic and contemporary psychopathological notions of obsessive-compulsive phenomena and discuss their relevance for differential diagnosis between...

DOI: 10.1016/j.schres.2022.02.014 Full text Phenomenology Diagnosis Psychosis Schizotypal disorder +2

Mindfulness meditation for Chinese patients with psychosis: A systematic review and meta-analysis.

Schizophrenia Research September 9, 2021 T. J. Tao, C. Hui, Bertha S. T. Lam et al.

Mindfulness meditation (MM) and its alignment with the mind-body perspective of health in Chinese cultures indicate its potential to benefit Chinese patients with psychosis. This is the first systematic review and meta-analysis to address the following questions: (1) Does MM improve clinical, well-being, and third-wave outcomes (i.e., mindfulness, acceptance, and compassion levels) among...

DOI: 10.1016/j.schres.2021.08.033

Sleep and psychotic symptoms: An actigraphy and diary study with young adults with low and elevated psychosis proneness.

Schizophrenia Research July 1, 2020 Timo Hennig, Björn Schlier, Tania M Lincoln

Experimental research has shown that poor sleep triggers psychotic experiences, even in healthy participants. This warrants an in-depth investigation of this mechanism in a naturalistic environment, an exploration of which particular aspects of poor sleep trigger psychotic symptoms, and a test for reverse effects of symptoms on sleep. For this purpose, we conducted a 14-day ambulatory...

DOI: 10.1016/j.schres.2019.09.012 Full text Dreaming Hallucinations Nightmares Paranoia +2

Does cannabis use predict psychometric schizotypy via aberrant salience?

Schizophrenia Research April 6, 2020 Colm O’Tuathaigh, Christopher Dawes, Andrea Bickerdike et al. 13 citations

Cannabis can induce acute psychotic symptoms in healthy individuals and exacerbate pre-existing psychotic symptoms in patients with schizophrenia. Inappropriate salience allocation is hypothesised to be central to the association between dopamine dysregulation and psychotic symptoms. This study examined whether cannabis use is associated with self-reported salience dysfunction and schizotypal...

DOI: 10.1016/j.schres.2020.03.021 Cannabis Schizotypy Schizotypal personality disorder Clinical psychology +6

Altered self-recognition in patients with schizophrenia.

Schizophrenia Research April 1, 2020 Karl Erik Sandsten, Julie Nordgaard, Troels Wesenberg Kjaer et al. 45 citations

Self-alienation is a common characterization of various disturbing experiences in patients with schizophrenia. A vivid example comes from patient reports of not recognizing themselves when inspecting their specular image in the mirror. By applying the multisensory paradigm of the Enfacement Illusion, this study empirically addresses the specular Self-Other discrimination in patients with...

DOI: 10.1016/j.schres.2020.01.022 Full text Body-illusions Enfacement illusion Multisensory integration Neurophenomenology +1

Meditation-based mind-body therapies for negative symptoms of schizophrenia: Systematic review of randomized controlled trials and meta-analysis.

Schizophrenia Research October 1, 2019 Michel Sabé, Othman Sentissi, Stefan Kaiser

Meditation-based mind-body therapies (yoga, tai-chi, qi-gong, mindfulness) have been suggested to have a potential therapeutic effect on negative symptoms. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) examining effectiveness of yoga, tai-chi, qi-gong and mindfulness on negative symptoms of schizophrenia, using different databases and trial...

DOI: 10.1016/j.schres.2019.07.030

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