Frontiers in Behavioral Neuroscience
June 10, 2026
Swapan Samanta, Nirmal Sultania, Mukul Roychoudhury et al.
The purpose of the present paper is not to validate the metaphysical claims of yogic traditions, but to examine whether their phenomenological descriptions correspond to measurable physiological processes. The proposal advanced here is explicitly theoretical: a hypothesis-generating model informed by preliminary retrospective clinical observations, not a claim of established proof. All...
Frontiers in Behavioral Neuroscience
April 16, 2026
Chen Hanna Ryder, Carmit Gal, Einav Levy et al.
Introduction With expanding global cannabis legalization and rising usage rates, elucidating the specific neurocognitive impact of acute cannabis intoxication across biological sexes is critical. Methods Using a 2 × 2 factorial design, we examined 154 adults: 77 individuals who use cannabis regularly (≥ 5 days/week for ≥ 1 year; 46 males, 31 females) and 77 matched controls (32 males, 45...
Frontiers in Behavioral Neuroscience
2026
Dayna Forsyth, Nicoletta Faraone, Simon G. Lamarre et al.
Non-human models, including fish, are increasingly important for investigating how pharmacological agents such as hallucinogens influence behavior, physiology, and cellular processes. These models help to reveal underlying mechanisms and to support assessments of toxicological impact, efficacy, and safety. In this study, we used isogenic lineages of the amphibious mangrove rivulus (Kryptolebias...
Frontiers in Behavioral Neuroscience
July 1, 2025
Richard G. Hunter, Annelise Madison, Jonathon K. Lisano et al.
Introduction Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have demonstrated anti-inflammatory properties. This study aimed to assess if cannabis use altered cytokine concentration and whether inflammatory status moderated the influence of 4 weeks of cannabis use on...
Frontiers in Behavioral Neuroscience
2025
Kelly Barnett, Fabian Vasiu
Flow is characterized by complete immersion and optimal engagement in a task, striking a balance between challenge and skill. Recent neuroimaging studies suggest that flow involves dynamic interactions among large-scale brain networks, particularly the default mode network (DMN) and the executive control network (ECN). This review aims to synthesize current findings on how flow-related DMN-ECN...
Frontiers in Behavioral Neuroscience
December 23, 2024
Aldrich Chan, Philip D. Harvey, R Hernandez-Cardenache et al.
9 citations
While PTSD continues to be researched in great depth, less attention has been given to the continuum of traumatic responses that resides outside this diagnosis. This investigation begins with a literature review examining the spectrum of responses through the lens of the default mode network (DMN). To build upon this literature, a systematic exploratory study was incorporated, examining...
Frontiers in Behavioral Neuroscience
March 21, 2023
Shiao-Fei Guu, Yi-Ping Chao, Feng-Ying Huang et al.
28 citations
Mindfulness refers to a mental state of awareness of internal experience without judgment. Studies have suggested that each mindfulness practice may involve a unique mental state, but the underlying neurophysiological mechanisms remain unknown. Here we examined how distinct mindfulness practices after mindfulness-based intervention alter brain functionality. Specifically, we investigated the...
Frontiers in Behavioral Neuroscience
August 18, 2022
Motoaki Sugiura
OPINION article Front. Behav. Neurosci., 18 August 2022Sec. Emotion Regulation and Processing Volume 16 - 2022 | https://doi.org/10.3389/fnbeh.2022.943809
Frontiers in Behavioral Neuroscience
April 14, 2022
Shuai Yang, Ke Xu, Xuan Xu et al.
This study aims to explore the regulatory effect of S-ketamine on the mechanical allodynia, anxiety-like behaviors and microglia activation in adult male rats exposed to an animal model of post-traumatic stress disorder (PTSD). The rat PTSD model was established by the exposure to single-prolonged stress (SPS), and 1 day later, rats were intraperitoneally injected with 5 mg/kg S-ketamine or...
Frontiers in Behavioral Neuroscience
March 2, 2022
Yaping Chen, Mengxin Shen, Xu Liu et al.
Accumulating evidence suggests that glutamate clearance plays a critical role in the pathophysiology and treatment of depression. Preclinical and clinical studies have demonstrated that ketamine provides an immediate and sustained antidepressant effect. However, the precise mechanism of its action remains to be elucidated. Glutamate transporter 1 (GLT1) participates in glutamate clearance;...
Frontiers in Behavioral Neuroscience
February 10, 2022
Matthew B Pomrenze, Franciely Paliarin, Rajani Maiya
27 citations
Substance use disorders in humans have significant social influences, both positive and negative. While prosocial behaviors promote group cooperation and are naturally rewarding, distressing social encounters, such as aggression exhibited by a conspecific, are aversive and can enhance the sensitivity to rewarding substances, promote the acquisition of drug-taking, and reinstate drug-seeking. On...
Frontiers in Behavioral Neuroscience
2022
Maria Lara Porpino de Meiroz Grilo, Geovan Menezes de Sousa, Lilían Andrade Carlos de Mendonça et al.
12 citations
Observational studies of long-term users of ayahuasca, an Amazonian psychedelic brew, suggest an increase in resilience via improvements in emotion and cognition. Ayahuasca has also demonstrated clinical antidepressant effects in human and animal studies; however, its potential prophylactic action in depression has not been previously studied. Therefore, this experimental study sought to...
Frontiers in Behavioral Neuroscience
December 16, 2021
Sophia Khom, Jacques D. Nguyen, Sophia A. Vandewater et al.
12 citations
Male rats escalate intravenous self-administration of entactogen psychostimulants, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxymethamphetamine (MDMA) under extended access conditions, as with typical psychostimulants. Here, we investigated whether female rats escalate self-administration of methylone, 3,4-methylenedioxypentedrone (pentylone), and MDMA and then studied...
Frontiers in Behavioral Neuroscience
December 3, 2021
Michael Colla, Hanne Scheerer, Steffi Weidt et al.
9 citations
The serendipitous discovery of ketamine's antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects seemingly without targeting monoaminergic pathways in the conventional way. In consequence, the...
Frontiers in Behavioral Neuroscience
July 23, 2021
Hadley Rahrig, James M. Bjork, Camila Tirado et al.
17 citations
Reactive aggression, a hostile retaliatory response to perceived threat, has been attributed to failures in emotion regulation. Interventions for reactive aggression have largely focused on cognitive control training, which target top-down emotion regulation mechanisms to inhibit aggressive impulses. Recent theory suggests that mindfulness training (MT) improves emotion regulation via both...
Frontiers in Behavioral Neuroscience
June 23, 2021
Alina Wilkowska, Łukasz P. Szałach, Wiesław Jerzy Cubała
32 citations
According to the WHO, major depressive disorder is the leading cause of disability worldwide, and it is a major contributor to the overall global burden of disease. The pathophysiology of this common and chronic disease is still not completely understood. The gut microbiome is an increasingly recognized environmental factor that can have a role in depression, acting through the...
Frontiers in Behavioral Neuroscience
June 11, 2021
Maria Bernardete Cordeiro de Sousa, Maria Lara Porpino de Meiroz Grilo, Nicole Leite Galvão‐coelho
7 citations
Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies showed that they are mainly monogamous, live in relatively stable social groups according to a...
Frontiers in Behavioral Neuroscience
2021
Brian Key, Oressia Zalucki, Deborah J Brown
How subjective experience is realized in nervous systems remains one of the great challenges in the natural sciences. An answer to this question should resolve debate about which animals are capable of subjective experience. We contend that subjective experience of sensory stimuli is dependent on the brain's awareness of its internal neural processing of these stimuli. This premise is supported...
Frontiers in Behavioral Neuroscience
2020
Thurston Lacalli
A number of conceptual difficulties arise when considering the evolutionary origin of consciousness from the pre-conscious condition. There are parallels here with biological pattern formation, where, according to Alan Turing's original formulation of the problem, the statistical properties of molecular-level processes serve as a source of incipient pattern. By analogy, the evolution of...
Frontiers in Behavioral Neuroscience
October 2, 2019
F. von Düring, I. Ristow, M. Li et al.
Background Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during...
Frontiers in Behavioral Neuroscience
December 4, 2018
Chenyi Chen, Yu-Chun Chen, Kuan-Ling Chen et al.
While meditation has drawn much attention in cognitive neuroscience, the neural mechanisms underlying its emotional processing remains elusive. Sant Mat meditators were recruited, who adopt a loving-kindness mode of meditation along with a vegetarian diet and an alcohol-restricted lifestyle and novices. We assessed their State-Trait Anxiety Inventory (STAI) and scanned their amygdala reactivity...
Frontiers in Behavioral Neuroscience
October 9, 2018
Yu Yang, Weina Ju, Haining Zhang et al.
80 citations
Depression is a common mental disorder that is associated with memory dysfunction. Ketamine has recently been demonstrated to be a rapid antidepressant. The mechanisms underlying how depression induces memory dysfunction and how ketamine relieves depressive symptoms remain poorly understood. In this work, we have three groups of male C57BL/6J mice: mice exposed to chronic social defeat stress...
Frontiers in Behavioral Neuroscience
October 8, 2018
Gennady G. Knyazev, Ekaterina A. Merkulova, Alexander N. Savostyanov et al.
Humans are social beings and the self is inevitably conceptualized in terms of social environment. The degree to which the self is perceived as fundamentally similar or fundamentally different from other people is modulated by cultural stereotypes, such as collectivism and individualism. These stereotypes are not hardwired in our brains and individuals differ in the degree to which they adopt...
Frontiers in Behavioral Neuroscience
August 27, 2018
Bruno Lobão‐soares, Paulianny Eduardo-Da-Silva, Hugo Amarilha et al.
15 citations
Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits. Ayahuasca effects are caused by the synergistic interaction of β-carbolines (harmine, harmaline and tetrahydroarmine) contained in Banisteriopsis caapi stalks combined with the N,N-dimethyltryptamine (DMT) from Psychotria...
Frontiers in Behavioral Neuroscience
August 2, 2018
Barbara Budzynska, Artur Wnorowski, Katarzyna Kaszubska et al.
9 citations
3,4-Methylenedioxy-methylamphetamine (MDMA), a synthetic substance commonly known as ecstasy, is a worldwide recreational drug of abuse. As MDMA and nicotine activate the same neuronal pathways, we examined the influence of co-administration of nicotine (0.05 mg/kg) and MDMA (1 mg/kg) on cognitive processes, nicotine-induced behavioral sensitization and on processes linked with oxidative stress...