Der Nervenarzt
August 17, 2026
Stefan Vestring, Katharina Domschke, Claus Normann
Ketamine has been established as an anesthetic agent for decades. Around the turn of the millennium initial clinical studies demonstrated that subanesthetic doses of ketamine can exert antidepressant effects in treatment-resistant depression. These findings established the concept of an effective glutamatergic antidepressant treatment and initiated a paradigm shift. For many years, intravenous...
Der Nervenarzt
March 1, 2025
Moritz Spangemacher, Jonathan R Reinwald, Hana Adolphi et al.
Novel antidepressive substances are challenging the explanations for the mechanisms of action of traditional psychopharmacology. What could be the shared effects of various antidepressants and in this context what role do extrapharmacological factors, such as the body and environment, play? The available literature on clinical and preclinical data for assumed combined active factors of...
Der Nervenarzt
February 12, 2025
Nina Hartter, Marvin Däumichen, Christopher Schmidt et al.
1 citation
Clinical studies with psilocybin in combination with psychotherapy show promising results for the treatment of various mental disorders; however, there still exists a lack of knowledge, rejection and prejudice towards this new form of therapy among doctors, psychotherapists and patients. The aim of this study was to gain a representative impression, as far as possible, of the level of...
Der Nervenarzt
September 1, 2024
Johannes Jungwirth, Francesco Bavato, Boris B. Quednow
6 citations
With the discovery of the antidepressive effects of ketamine and the increasing withdrawal of the pharmaceutical industry from the development of new psychotropic drugs, the psychiatric research into the clinical application of hallucinogens in psychiatry has literally blossomed in the last two decades. Promising results for various treatment approaches with psychedelic agents, such lysergic...
Der Nervenarzt
May 1, 2024
Bernhard T Baune, Sarah E Fromme, Maximilian Kiebs et al.
1 citation
Treatment-resistant depression (TRD) is a complex disorder. Although no standardized definition has been established to date, there are promising and well-established treatment options for the condition. Looking at the current pharmacological and neuromodulatory strategies, there is an urgent need for fast-acting and well-tolerated treatment options. The search for new mechanisms of action goes...
Der Nervenarzt
September 1, 2023
Dusan Hirjak, Jonas Daub, Geva A Brandt et al.
6 citations
Historical authors (e.g., Ludwig Binswanger and Eugène Minkowski) postulated that the experience of patients with schizophrenia is characterized by time fragmentation. From a clinical perspective, patients with schizophrenia also suffer from difficulties in spatial perception (e.g., abnormalities in the experience of interpersonal distance and spatial orientation). Although these changes can...
Der Nervenarzt
March 1, 2022
Gerhard Gründer, Manuela Brand, Laura Kärtner et al.
Psychedelics, such as psilocybin represent one of the most promising current therapeutic approaches in psychiatry. Psychedelics seem to have not only potent antidepressant effects. Do they also work particularly quickly, i.e. within one day? The available literature on clinical studies of psychedelics in depressive syndromes is presented both from the period up to the prohibition of these...
Der Nervenarzt
March 3, 2021
Dusan Hirjak, Andreas Meyer‐Lindenberg, Geva A. Brandt et al.
8 citations
Zusammenfassung Substanzinduzierte psychotische Störungen (SIPS) sind häufig und für ca. 25 % der ersten Einweisungen in eine psychiatrische Klinik verantwortlich. Aus klinischer Sicht ist aufgrund ähnlicher psychopathologischer Phänomene die diagnostische Unterscheidung zwischen SIPS und primären (genuinen oder kryptogenen) psychotischen Störungen oft eine Herausforderung. Dieser Umstand wird...
Der Nervenarzt
September 1, 2018
K Meister, S Becker
The demand for complementary clinically efficacious, safe, patient acceptable, and cost-effective forms of treatment for mental illness is growing. Yoga has beneficial effects on somatic and mental health factors; therefore, yoga has preventive and therapeutic capabilities to improve mental dysfunction. In this overview of the current literature, the evidence of the effects of yoga on selected...
Der Nervenarzt
March 1, 2013
T Passie, J Warncke, T Peschel et al.
3 citations
Religions are evolutionary selected social and cultural phenomena. They represent today belief and normative systems on which the main parts of our culture are based. For a long time religions have been seen as mainly originating from a spectrum of religious experiences. These include a broad spectrum of experiences and are astonishingly widespread in the population. The most consistent and...
Der Nervenarzt
September 2010
M Bürgy
The phenomena which Kurt Schneider grouped together to form the ego disturbances have always been of particular diagnostic relevance for schizophrenia. While little importance was historically attached to accurately describing and distinguishing psychopathological symptoms, Karl Jaspers' and Kurt Schneider's descriptive psychopathology aims to draw a sharp yet differentiated distinction between...
Der Nervenarzt
May 2009
M Bürgy
The accomplishments of Heidelberg psychopathology and their continued development are illustrated using the example of the concept of psychosis. Jaspers founded the Heidelberg school by methodologically collating the psychiatric knowledge of his time in a structured fashion and in doing so laid the foundation for modern nosology. While, however, ICD and DSM classifications tend to be modelled...
Der Nervenarzt
July 2008
O Seidl
Therese Neumann, from Konnersreuth in Bavaria, developed stigmata at the age of 29 and allegedly lived without any food for 36 years. After a fire accident in 1918, she suffered from paralysis, deafness, and blindness. Later she developed stigmata on her extremities and left side of the thorax, bleeding lesions in the skin, bleeding in the eye region, and altered states of consciousness in the...
Der Nervenarzt
April 2007
N J Diederich
REM or dreaming sleep is one of three states of consciousness. It is characterized by rapid eye movements, muscle atonia, desynchronized EEG, and autonomic dysregulation. A dysfunction of one of these four cardinal traits explains the primary disorders of REM sleep, including REM sleep behavior disorder and narcolepsy. Although seen in other stages, sleep apnea syndrome, coronary syndromes, and...
Der Nervenarzt
January 2006
Udo Benzenhöfer, Torsten Passie
There is no consensus in the literature regarding the early history of MDMA (Methylendioxymethamphetamine, so-called "Ecstasy"). Various authors credit the first synthesis of MDMA to the German chemist Fritz Haber, but it appears neither in his doctoral thesis (Berlin 1891) nor in his accompanying articles. The man who first synthesized MDMA was the chemist Dr. Anton Köllisch, who worked for...
Der Nervenarzt
October 1, 2005
Christian Brandt, D Brechtelsbauer, Christian G Bien et al.
Out-of-body experiences are reported in a variety of diseases and physiologic conditions. We report a 44-year-old patient with epigastric auras, psychomotor and grand mal seizures, and paroxysmal experiences during which he believed to have left his body and seen himself from the outside. Electroencephalography showed a right temporal and right parietal seizure pattern on several occasions, and...