Neuron
October 1, 2026
Urs Braun, Johannes Wolf, Dusan Hirjak et al.
Psychotic symptoms, including hallucinations, delusions, and disorganized thought, occur across psychiatric and neurological disorders, yet their underlying mechanisms remain poorly integrated across scales. Here, we propose a transdiagnostic framework in which disturbances in dopamine, glutamate, GABA, serotonin, and acetylcholine alter neuronal gain and synaptic efficacy, disrupting the...
Schizophrenia Research
July 23, 2026
Jonas Daub, S. Volkmer, D. Altinok et al.
BACKGROUND Altered experiences of space and time are core features of schizophrenia spectrum disorders (SSD) and mood disorders (MOD). In this study, we investigated whether patients with SSD and MOD exhibit shared or distinct patterns of subjective spatiotemporal experience. METHODS We examined 62 ICD-11 patients (33 SSD, 29 MOD) using the Scale for Space and Time Experience in Psychosis...
Psychopathology
June 30, 2025
Stephan Lechner, Karl Erik Sandsten, Dusan Hirjak et al.
7 citations
The psychopathology of schizophrenia is a complex amalgamation of features that span across different dimensions. These dimensions range from the experience of altered time and space through self-disorders to perceptual, positive, and negative symptoms. The relationship between these different psychopathological dimensions remains unclear. Addressing this gap was the aim of our study. We...
Schizophrenia Research
2024
Georg Northoff, Dusan Hirjak
Catatonia is featured by complex symptoms combining motor, affective and behavioral phenomena as well as by its syndrome character with trans-diagnostic occurrence. It paradigmatically shows the limits of current forms of psychopathology like affective and cognitive approaches with respect to both clinical symptoms and brain mechanisms. We therefore suggest Spatiotemporal Psychopathology (STPP)...
Der Nervenarzt
September 1, 2023
Dusan Hirjak, Jonas Daub, Geva A Brandt et al.
6 citations
Historical authors (e.g., Ludwig Binswanger and Eugène Minkowski) postulated that the experience of patients with schizophrenia is characterized by time fragmentation. From a clinical perspective, patients with schizophrenia also suffer from difficulties in spatial perception (e.g., abnormalities in the experience of interpersonal distance and spatial orientation). Although these changes can...
Schizophrenia Research
June 1, 2023
Geva A Brandt, Stefan Fritze, Maria Krayem et al.
BACKGROUND In the last two decades, much neuroscientific research has been done on the pathomechanisms of catatonia. However, catatonic symptoms have mainly been assessed with clinical rating scales based on observer ratings. Although catatonia is often associated with strong affective reactions, the subjective domain of catatonia has simply been neglected in scientific research. METHODS The...
Addiction Biology
November 22, 2021
Dusan Hirjak, Mike M. Schmitgen, Florian Werler et al.
33 citations
Heavy cannabis use (HCU) is frequently associated with a plethora of cognitive, psychopathological and sensorimotor phenomena. Although HCU is frequent, specific patterns of abnormal brain structure and function underlying HCU in individuals presenting without cannabis-use disorder or other current and life-time major mental disorders are unclear at present. This multimodal magnetic resonance...
Der Nervenarzt
March 3, 2021
Dusan Hirjak, Andreas Meyer‐Lindenberg, Geva A Brandt et al.
8 citations
Zusammenfassung Substanzinduzierte psychotische Störungen (SIPS) sind häufig und für ca. 25 % der ersten Einweisungen in eine psychiatrische Klinik verantwortlich. Aus klinischer Sicht ist aufgrund ähnlicher psychopathologischer Phänomene die diagnostische Unterscheidung zwischen SIPS und primären (genuinen oder kryptogenen) psychotischen Störungen oft eine Herausforderung. Dieser Umstand wird...
European Addiction Research
October 20, 2020
Miriam Wittemann, Jule Brielmaier, M. Rubly et al.
Introduction: Acute and long-term adverse effects of heavy cannabis use (HCU) on neurocognitive function have been suggested, as much as regional changes of brain volume. However, little is known about the relationship between impaired cognition and brain structure in individuals with HCU. Objective: Here, we investigated associations between cognition and cortical thickness (CT) in males with...
PLoS One
September 3, 2013
Dusan Hirjak, Thiemo Breyer, Philipp Arthur Thomann et al.
47 citations
OBJECTIVES: In 1950, Kurt Schneider proposed that a considerable number of schizophrenia patients develop first-rank symptoms (FRS). In such cases, patients report made experiences, replaced control of will, thought insertion, broadcast or withdrawal and delusional perception, respectively. Although a number of recent studies tend to explain FRS in terms of neurobiological and...