Sleep science (Sao Paulo, Brazil)
January 1, 2022
Ravindra P. Nagendra, Talakad N. Sathyaprabha, Bindu M Kutty
11 citations
Long-term Vipassana meditators show increased slow-wave (N3) and REM sleep compared to non-meditators. Evening cortisol levels are similar between groups, but early morning cortisol, diurnal dehydroepiandrosterone (DHEA), and melatonin are significantly higher in meditators. Diurnal DHEA correlates significantly with N3 sleep in meditators. Higher diurnal DHEA despite comparable cortisol suggests that long-term meditation modulates the hypothalamic-pituitary-adrenal (HPA) axis, influencing sleep architecture. This provides evidence for exploring mindfulness meditation as an intervention for insomnia.
bioRxiv Preprint Server
August 29, 2024
Saketh Malipeddi, Arun Sasidharan, Rahul Venugopal et al.
4 citations
preprint
Advanced meditators from the Isha Yoga tradition show shorter intrinsic neural timescales (INTs) during breath-watching, indicating deidentification with mental contents, and no significant differences in INTs between tasks, indicating non-dual awareness. Shorter INTs correlate with self-reported equanimity. The brain's intrinsic neural timescales may serve as a neural marker of equanimity.
bioRxiv Preprint Server
February 11, 2025
Saketh Malipeddi, Arun Sasidharan, Rahul Venugopal et al.
2 citations
preprint
Meditation alters brain activity, particularly in alpha and theta frequency bands, but most research has focused on average power changes from rest to meditation rather than how quickly these changes emerge. This gap means little is known about the time-to-onset and temporal dynamics of neural shifts during meditation practice.
bioRxiv (Cold Spring Harbor Laboratory)
June 26, 2025
Prakash Shrimali, Arun Sasidharan, Saketh Malipeddi et al.
1 citation
preprint
Meditation involves training attention inward, but the brain activity that distinguishes meditative from non-meditative states across different traditions is not well understood. Analyzing high-density EEG data from 170 participants—121 advanced meditators and 49 controls—across Vipassana, Brahma Kumaris Raja Yoga, Heartfulness, and Isha Yoga traditions, researchers used random forest classifiers to distinguish meditative from non-meditative states with 91% accuracy. Nonlinear features contributed most, indicating a core neurodynamic profile. Classification was higher in advanced meditators (92%) than controls (85%), with different feature importance: nonlinear and aperiodic features dominated in meditators, while oscillatory and timescale features dominated in controls. Each tradition showed distinct neurodynamic profiles, suggesting multiple pathways lead to meditative states.
Communications Biology
June 12, 2026
Saketh Malipeddi, Arun Sasidharan, Bianca Ventura et al.
Advanced meditators from the Isha Yoga tradition report stronger non-dual experiences—where the boundary between self and environment dissolves—during breath-watching meditation compared to novices and meditation-naïve controls. Using EEG-based intrinsic neural timescales (INT), researchers found that across all participants, INTs are longer during internal attention (breath-watching) than during an external cognitive task. However, advanced meditators show similar INT durations between internal and external attention, and this reduced difference correlates with stronger reported non-dual experiences. The findings suggest that similar intrinsic neural timescale durations across internal and external attention may be a neural signature of non-duality.
bioRxiv Preprint Server
May 27, 2026
Praerna Chowdhury, Ramajayam Govindaraj, Arun Sasidharan et al.
preprint
Meditation-related EEG patterns are often studied by comparing meditators to passive rest or by experience level, but such designs rarely test reliability or include active controls. This study used a multi-session within-subject design with experienced Brahmakumaris Rajayoga meditators to identify reliable, state-dependent EEG dynamics. The approach addressed prior limitations, providing more valid neurophysiological markers of meditative state.
bioRxiv (Cold Spring Harbor Laboratory)
September 9, 2025
Ratna Jyothi Kakumanu, Ajay Kumar Nair, Arun Sasidharan et al.
preprint
A novel approach using four EEG-based biomarkers—potentials, their first-order derivatives, and phase slip rates derived from each—distinguished novice Vipassana meditators from non-meditator controls. Phase slip rates, discontinuities in instantaneous phase representing cortical phase transitions, were computed from 128-channel EEG data collected during a visual oddball task. Eight novice Vipassana subjects and eight non-meditator controls each completed 50 trials; 44 artifact-free trials per subject were averaged. Spatiotemporal profiles of all four biomarkers differed significantly between groups, and the novice Vipassana subjects showed faster object recognition. The findings suggest phase slip rates offer a promising set of biomarkers for quantitative task-based EEG analyses.
Consciousness and Cognition
July 1, 2025
Gulshan Kumar, Safoora Naaz, Nahida Jabin et al.
Dream recall is more frequent after REM sleep than N2 sleep. During dream recall, EEG beta activity increases, functional connectivity within the default mode network strengthens, and the medial frontal cortex activates, regardless of sleep stage. Auditory stimulation during sleep can influence the emotional content of dreams, suggesting that targeted memory reactivation may be possible. These findings help clarify how conscious experience arises during sleep.
Neuroscience of Consciousness
January 1, 2026
Bianca Ventura, Andrea Buccellato, Saketh Malipeddi et al.
Vipassana and Shoonya meditation produce distinct alpha-band brain dynamics, with differences more apparent in temporal variability than in average activity. Vipassana, involving systematic body scanning, showed lower variability and more regular temporal patterns in both peak frequency and power of alpha oscillations. Shoonya, a non-directed attention practice, exhibited higher variability and irregularity in these measures. The findings suggest that dynamic features of brain activity, such as variability and temporal irregularity, may distinguish contemplative practices better than static averages, and could reflect a shared property of brain and experience.
The neuroradiology journal
June 1, 2023
Ashwini S Savanth, Vijaya Pa, Ajay K Nair et al.
Long-term meditation practice may produce neuroplastic changes that make cognitive processing more efficient. Using fMRI, researchers compared brain connectivity in long-term (average 13,596 hours) and short-term (average 1,095 hours) Rajayoga meditators from the Brahma Kumaris while they performed an engaging task with audio-visual distractions. A machine learning classifier (Gradient Boosted Tree) distinguished the two groups with 77% accuracy based on functional connectivity metrics. Connectivity was higher in long-term meditators in visual areas, cerebellum, left rostral prefrontal cortex, and middle frontal gyrus, suggesting that extensive meditation practice can lead to more effortless cognitive processing.
Sleep Science
June 17, 2022
Ravindra P. Nagendra, Talakad N. Sathyaprabha, Bindu M Kutty
Long-term Vipassana meditators show increased N3 (slow-wave) and REM sleep stages compared to non-meditators. Evening cortisol levels were similar between groups, but early morning cortisol, diurnal dehydroepiandrosterone (DHEA), and melatonin were significantly higher in meditators. Diurnal DHEA correlated significantly with N3 sleep stage in meditators. These findings suggest that long-term Vipassana meditation practice modulates the hypothalamic-pituitary-adrenal (HPA) axis and thereby influences sleep, providing evidence to explore mechanisms involved with mindfulness meditation intervention in insomnia.
International Journal of Yoga
January 1, 2022
Ashwini S Savanth, P A Vijaya, Ajay Kumar Nair et al.
Long-term Rajayoga meditators from the Brahma Kumaris tradition show distinct brain functional connectivity patterns compared to short-term practitioners, even while performing a non-meditative task. Using task-based fMRI data, graph-theoretical measures of functional connectivity (adjacency matrices, global efficiency, local efficiency) were calculated from 132 brain regions. Machine learning classifiers—especially decision tree, random forest, and gradient boosted tree—achieved over 84% test accuracy in distinguishing long-term (mean 13,596 hours of practice) from short-term (mean 1,095 hours) meditators. These findings suggest that extensive meditation practice produces lasting changes in brain network organization that persist outside of meditation.
Progress in Brain Research
January 1, 2019
Ratna Jyothi Kakumanu, Ajay Kumar Nair, Arun Sasidharan et al.
Long-term Vipassana meditation practice, both in duration and quality, is linked to graded differences in brain activity during a cognitive task. After an hour of meditation, three groups of practitioners—novices, seniors, and teachers—performed a gamified oddball task while EEG was recorded. All groups performed well and showed similar overall brain-wave patterns, but more experienced meditators exhibited reduced theta synchrony, enhanced alpha desynchronization, and lesser theta-alpha coherence. Teachers differed most from novices, with seniors forming an intermediate group. The findings suggest that both the quantity and quality of meditation influence EEG dynamics during cognitive processing, and that meditating before a task can amplify these state-trait effects.
Biological Psychology
May 1, 2018
Ratna Jyothi Kakumanu, Ajay Kumar Nair, Rahul Venugopal et al.
Vipassana meditation, as taught by S.N. Goenka, involves distinct EEG patterns that vary by technique and practitioner proficiency. Compared to Novices, Senior meditators and Teachers showed greater delta, theta-alpha, and low-gamma power at rest. During concentrative and mindfulness meditation, they exhibited increased low-alpha and low-gamma power; during loving-kindness meditation, increased theta-alpha and low-gamma power. Measures of permutation entropy and Higuchi fractal dimension revealed that only Teachers, not Seniors, displayed consistent increases in network complexity from rest and across meditation states, indicating that high proficiency, not just duration of experience, drives neural complexity changes.
International review of psychiatry (Abingdon, England)
June 1, 2016
Nirmala Maruthai, Ravindra P. Nagendra, Arun Sasidharan et al.
Senior Vipassana meditators show distinct changes in sleep organization, including enhanced slow wave sleep and REM sleep, fewer intermittent awakenings, and reduced non-REM stage 2 sleep compared to novice meditators and non-meditators. Their REM sleep organization differs significantly, with more REM episodes, longer episodes, and increased phasic and tonic rapid eye movement activity (REMA), along with enhanced burst events during the second and fourth REM episodes. No significant differences in REM sleep organization were observed between novice meditators and controls. These changes may reflect intense brain plasticity from meditative practices.