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Science June 13, 1975 Ian R. Brown, C. C. Liew
Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamide gels.
Journal of Pharmacology and Experimental Therapeutics June 1, 1975 D. Gallager, George K. Aghajanian 83 citations
The effects of d-lysergic acid diethylamide (LSD) and chlorimipramine (CIMI) on the firing rate of serotonergic (5-HT) neurons and on the in vivo efflux of 5-HT were investigated in parallel. A cerebroventricular perfusing technique was used to measure the efflux of 3-H-5-HT formed in vivo from 3-H-tryptophan. Impulse flow in serotonergic neurons was monitored by single unit recording from...
Biochemical Society Transactions April 1, 1975 Zahid H. Siddik, Roger D. Barnes, L. G. Dring et al. 16 citations
Conference Article| April 01 1975 The Fate of Lysergic Acid Di[14C]ethylamide ([14C]LSD) in the Rat ZAHID H. SIDDIK; ZAHID H. SIDDIK 1Department of Biochemistry, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROGER D. BARNES; ROGER D. BARNES 1Department of Biochemistry, St. Mary's Hospital Medical School, London...
Proceedings of the National Academy of Sciences March 1, 1975 Ian R. Brown 24 citations
RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar RNA synthesis were increased. The main activity in the isolated nuclei assay...
Clinical Toxicology 1975 John Klock, Udo Boerner, Charles E. Becker 78 citations
Eight patients were seen within 15 min of intranasal self-administration of large amounts of pure D-lysergic acid diethylamide (LSD) tartrate powder. Emesis and collapse occurred along with sign of sympathetic overactivity, hyperthermia, coma, and respiratory arrest. Mild generalized bleeding occurred in several patients and evidence of platelet dysfunction was present in all. Serum and gastric...
British Journal of Pharmacology November 1, 1974 Alan R. King, Ian L. Martin, Kathleen Melville 38 citations
Small doses of lysergic acid diethylamide (LSD) (12.5–50 μg/kg) consistently facilitated learning of a brightness discrimination reversal. 2‐Bromo‐lysergic acid diethylamide (BOL‐148), a structural analogue of LSD, with similar peripheral anti‐5‐hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg). LSD, but not...
Archives of General Psychiatry November 1, 1974 Charles M. Culver 53 citations
An extended battery of neuropsychological tests was administered to three groups of college seniors (lysergic acid diethylamide [LSD]/mescaline users; marihuana/hashish users; and controls) who were matched on predrug usage intellectual and personality dimensions. The study was replicated one year later. In the combined-years' analyses, the three groups showed statistically significant...
Archives of Ophthalmology October 1, 1974 D. J. Apple, Tina Bennett 27 citations
A boy was born with multiple malformations including anencephaly with ectopic placenta, absent left arm, cleft lip and palate, syndactyly, coloboma of the iris, cataract, and corneal opacity with vascularization. The mother had used lysergic acid diethylamide (LSD) before and during pregnancy. The limb amputation deformities are the primary findings in this case. These changes are sufficiently...
The British Journal of Psychiatry September 1, 1974 J. Robinson, R. G. Chitham, Ronni Michelle Greenwood et al. 13 citations
While the beneficial effect of lysergic acid diethylamide (LSD) in the treatment of carefully selected patients as an adjunct to psychotherapy has been amply reported (Robinson et al. , 1963), concern has been expressed regarding the damage to chromosomes in those taking the drug.
Chemischer Informationsdienst August 20, 1974 Y. Nakahara, Tetsukichi Niwaguchi
AbstractDie Amidierung von Lysergsäure (I) in Gegenwart von Triphenylphosphit/Imidazol/ Phosphorsäure‐tris‐(dimethylamid) oder Phosphorsäure‐tris‐(dimethylamid)/Tosyl= Chlorid liefert die Verbindungen (II) und (III), wobei bei Verwendung des letztgenanr ten Reagens die Verbindungen (II) in 68‐75%iger und die Verbindungen (III) in bis 3 zu 8%iger Ausbeute erhalten werden.