Multiple Systemic and Ocular Malformations Associated With Maternal LSD Usage
Archives of Ophthalmology October 1, 1974 DOI: 10.1001/archopht.1974.01010010311008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Male infant exposed to LSD in utero |
| Topics | LSD |
| Keywords | Coloboma Syndactyly Anencephaly Pregnancy Ingestion Fetus |
| Citations | 27 |
| Key findings | Limb amputation deformities and lens abnormalities in an infant are associated with maternal LSD ingestion during pregnancy. |
Abstract
A boy was born with multiple malformations including anencephaly with ectopic placenta, absent left arm, cleft lip and palate, syndactyly, coloboma of the iris, cataract, and corneal opacity with vascularization. The mother had used lysergic acid diethylamide (LSD) before and during pregnancy. The limb amputation deformities are the primary findings in this case. These changes are sufficiently specific to suggest a correlation with other reported cases in which a higher than expected incidence of such deformities are observed in infants following maternal ingestion of the drug. This is only the second recorded case of lens abnormalities associated with maternal LSD ingestion.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
Citations in the library
Cited by 3
- Multiple Ocular Anomalies Associated With Maternal LSD Ingestion Archives of Ophthalmology February 1, 1978
- Optic Disc Anomalies and Maternal Ingestion of LSD Journal of Pediatric Ophthalmology & Strabismus September 1, 1978
- Psychedelic exposure in pregnancy: a scoping review to inform perinatal drug safety and clinical counseling. Therapeutic advances in drug safety 2026