A radioimmnunoassay for d-lysergic acid diethylamide (LSD) is described. Antibodies to LSD were obtained by immunizing rabbits with a conjugate of LSD and human serum albumin. The specificity of the antibody was shown by competitive binding studies. The method has been used to detect the presence of LSD in human urines. Picogram amounts can be measured by this assay.
A controlled investigation was made of the rehabilitative efficacy of brief residential psychedelic (LSD) psychotherapy with chronic heroin abusers. Seventy-eight volunteer addict inmates from Maryland correctional institutions were randomly assigned to the following: a treatment condition–psychedlic therapy (incorporating one high-dose LSD administration) during a six weeks residence in a...
Systematic desensitization in conjunction with other behavior techniques was utilized to treat a client who for 5 months was experiencing spontaneous recurrences of LSD effects. Besides the elimination of the target symptoms (flashback effects), additional desired changes occurred on both cognitive-affective and behavioral levels. A theoretical explanation of LSD flashback effects based on the...
Solar retinopathy is a condition that can result from focusing the eye(s) on the sun, and usually follows the independent viewing of a solar eclipse.It has also been reported after direct sun-gazing, in anti-aircraft lookouts (Flynn, 1942; Cordes, I944, I948), in mili- tary recruits hoping to obtain discharge from service (Ewald and Ritchey, I970), in hos- pitalized schizophrenic patients...
Judgments regarding various personality traits were made on 49 subjects and related to frequency of LSD use. Frequency of use was negatively related to understanding of self and others, to degree of consistency between professed values and behavior, and to a sense of ability to control one's life. No differences were found between various frequency of use groups in terms of general academic and...
The paper describes the results of a clinical study exploring the potential of a complex psychotherapeutic program utilizing psychedelic compounds to alleviate the emotional and physical suffering of cancer patients. A total of 60 cancer patients participated in this experimental study. In 44 of these patients, LSD (200-500 p%per os) was administered as an adjunct to psychotherapy; in 19...
One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of...
The molecular configuration of lysergic acid diethylamide (LSD) in crystals of the iodobenzoate has been determined by using x-ray diffraction techniques. The configuration shows strain and steric hindrance and the conformation is fixed. Some of the implications of this for the hallucinogenic activity of LSD are discussed.
A stimulus generalization procedure was used to investigate the effects of LSD on sensitivity to auditory stimuli in rats. The shape of the generalization gradient was changed after administration of the drug only with a dose which produced decreases in relatively high rates of responding.
Abstract Although there are reports of five children with limbs defects among 161 children from parents who took LSD (lysergic acid diethylamide) this review of the literature indicates that LSD does not cause chromosome breakage and that there is no strong evidence of teratogenicity in animals.