A 19‐year‐old boy, with Klinefelter's syndrome and a history of LSD usage, developed acute lymphoblastic leukemia. The possibility is discussed that this was caused by cytogenetic injuries subsequent to LSD exposure and the inherited chromosomal anomaly acting in concert.
(+)‐Lysergic acid diethylamide (LSD) mimicked 5‐hydroxytryptamine (5‐HT) in its ability to stimulate fluid secretion, to change transepithelial and intracellular potentials as well as to increase the cyclic 3′,5′‐adenosine monophosphate (cyclic AMP) concentrations of isolated salivary glands of Calliphora . Unlike 5‐HT, LSD disengages slowly from the receptor and fluid secretion continues...
AbstractThe preparation of lysergic acid [14C1]‐diethylamide is described. [14C1]‐Diethylamine was synthesised in three steps; sodium [14C1]‐acetate was treated with thionyl chloride giving [14C1]‐acetyl chloride which was reacted with ethylamine to give N‐ethyl‐[14C1]‐acetamide. Reduction of this amide with lithium aluminium hydride gave [14C1]‐diethylamine which on treatment with a lysergic...
An adenylate cyclase (EC 4.6.1.1) that is activated specifically by low concentrations of serotonin has been identified in homogenates of the thoracic ganglia of an insect nervous system. The activation of this enzyme by serotonin was selectively inhibited by extremely low concentrations of D-lysergic acid diethylamide (LSD), 2-bromo-LSD, and cyproheptadine, agents which are known to block...
A 20-year-old white woman developed a left hemiplegia following the ingestion of LSD. Initial angiography revealed marked constriction of the internal carotid artery at the level of the siphon which, in a few days, was converted to occlusion of the carotid artery at that level. It is suggested that LSD, an amine derivative of the ergot alkaloids, was responsible for the initial vasoconstriction...
Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to...
The LSD and schizophrenic experiences are similar in more ways than they are different. The states are phenomenologically similar, but the similarity is contaminated by the fact that no significant differences exist between these two groups and the control group on several measures, if the phenomena in question are regarded as isolated. Significant differences exist between the LSD and...
Numerous investigators have reported impressive improvement rates when LSD has been used as an aid to ongoing psychotherapy, but absence of controls makes these findings difficult to evaluate. In the present study, 21 psychosomatic inpatients and 7 nonpsychotic psychiatric inpatients were randomly assigned to two psychotherapy groups, one of which received five LSD sessions and a second which...
RésuméLes auteurs ont comparé des patients souffrant, à la suite de l'ingestion de LSD, de psychoses semblables à la schizophrénie, à des patients chez qui la schizophrénie est apparue en l'absence de l'emploi de drogues. Ils ont examiné les traits cliniques des syndromes et l'incidence familiale de la schizophrénie. Ils exposent en détail les différences observées; elles semblent confirmer...