Lysergic Acid Diethylamide: Effect on Histone Acetylation in Rabbit Brain
Ian R. Brown, C. C. Liew
Science June 13, 1975 DOI: 10.1126/science.1215990 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Dose | 10 and 100 micrograms per kilogram |
| Duration | 30 minutes after administration |
| Topics | LSD |
| Key findings | LSD increased histone acetylation in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration at doses of 10 and 100 micrograms per kilogram, with evidence of stimulated acetylation in individual histone bands after electrophoretic separation. |
Abstract
Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamide gels.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 10
- DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO Journal of Neurochemistry July 1, 1976
- Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling Progress in Neuro-Psychopharmacology and Biological Psychiatry June 28, 2022
- Epigenetic mechanisms of rapid-acting antidepressants Translational Psychiatry September 4, 2024
- Bedside to bench: the outlook for psychedelic research Frontiers in Pharmacology October 2, 2023
- Fate of mRNA following disaggregation of brain polysomes after administration of (+)-lysergic acid diethylamide in vivo Bba Section Nucleic Acids and Protein Synthesis November 22, 1979
and 5 more in the library