Neuropsychological Assessment of Undergraduate Marihuana and LSD Users
Archives of General Psychiatry November 1, 1974 DOI: 10.1001/archpsyc.1974.01760170093015 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | College seniors |
| Duration | One-year replication |
| Topics | LSD Mescaline |
| Keywords | Neuropsychology Hallucinogen Neuropsychological test Clinical psychology Cognition |
| Citations | 53 |
| Key findings | LSD/mescaline users performed significantly worse on the Trail Making Test than marijuana/hashish users and controls, even after controlling for alcohol use. |
Abstract
An extended battery of neuropsychological tests was administered to three groups of college seniors (lysergic acid diethylamide [LSD]/mescaline users; marihuana/hashish users; and controls) who were matched on predrug usage intellectual and personality dimensions. The study was replicated one year later. In the combined-years' analyses, the three groups showed statistically significant differences only on the Trail Making Test: LSD/mescaline users performed within normal limits but significantly worse than either of the other two groups. Since the three groups also differed significantly in the extent of their alcohol usage, a covariance analysis was carried out that indicated that this variable did not account for the LSD/mescaline group's performance on the Trail Making Test. Inference about possible organic dysfunction cannot be drawn from these findings, but prospective neuropsychological testing might prove useful.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 9
- Gone to Pot – A Review of the Association between Cannabis and Psychosis Frontiers in Psychiatry May 22, 2014
- Visual Phenomenology of the LSD Flashback Archives of General Psychiatry August 1, 1983
- Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects The Journal of Nervous and Mental Disease March 1, 1995
- Neuropsychological Functioning in Users of Serotonergic Psychedelics – A Systematic Review and Meta-Analysis Frontiers in Pharmacology September 16, 2021
- L-5-hydroxytryptophan for LSD-induced psychosis American Journal of Psychiatry April 1, 1983
and 4 more in the library