Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics.
Molecular Psychiatry July 28, 2026
Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics.
Ketamine research published in 2026
Page 10 of 35: studies 181 to 200 of 699, newest first. Back to the ketamine overview
Studies
CB1R-dependent mitochondrial biogenesis may contribute to the antidepressant effects of esketamine in a chronic variable stress male mouse model.
Neuroscience July 27, 2026 Wei Zhao, Xinxin Zhao, Yunyun Zhang et al.
Major depressive disorder (MDD) is a leading cause of disability worldwide, and current antidepressants are limited by delayed onset and incomplete efficacy. Esketamine produces antidepressant effects more rapidly than conventional treatments, but its underlying mechanisms remain unclear. We examined whether cannabinoid type 1 receptor (CB1R) signaling is associated with hippocampal...
DOI: 10.1016/j.neuroscience.2026.07.059 (opens in new tab)
Full text (opens in new tab)
Esketamine
Cb1 receptor
Chronic variable stress
Hippocampus
+1
A scoping review: ketamine or esketamine when used to assist psychotherapy or in combination with psychotherapy for the management of depression in adults
npj Mental Health Research July 27, 2026 Jennifer Swainson, P. Grewal, S. Polard et al.
This scoping review maps literature for use of ketamine or esketamine with psychotherapy for depression or depressive symptoms. Forty-seven studies were identified including 4/47 (9%) randomized controlled trials, 4/47 (9%) open label trials, 27/47 (57%) observational or retrospective studies, and 12/47 (26%) individual case reports. Studies were categorized as Ketamine/Esketamine Combined with...
Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation
IBRO Neuroscience Reports July 26, 2026 Jingwen Yang, Ting Huang, Meng Wang et al.
Background Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused on perineuronal nets (PNNs), an extracellular matrix structure that surrounds fast-spiking parvalbumin-positive interneurons and regulates...
Intravenous Ketamine for Depression and Suicidality in Borderline Personality Disorder and Borderline Personality Features: A Systematic Review
McMaster University Medical Journal July 26, 2026 Annie Xiong, Sebastian Kolde, Paul S. Links
Background: Pharmacologic treatment options for borderline personality disorder (BPD) remain limited, and no medication has received regulatory approval for its treatment. Given the high rates of comorbid depression and suicidal ideation in BPD, there is growing interest in novel therapeutic approaches. Ketamine has been approved for treatment-resistant depression and acute suicidality, raising...
The functional role of ERK activity in esketamine's antidepressant effects.
Pharmacology, Biochemistry, and Behavior July 26, 2026 Peng Zhang, Mengyu Wu, Keke Zhang et al.
Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potential side effects of repeated esketamine use. Here, we found that increasing extracellular signal-regulated kinase (ERK) activity by pharmacologically...
DOI: 10.1016/j.pbb.2026.174248 (opens in new tab)
Full text (opens in new tab)
Esketamine
Treatment-resistant depression
Bdnf-trkb signaling pathway
Erk activity
+1
Bidirectional control of vesicular GABA release, LTP, and amotivation by GluN2D-selective allosteric modulators and ketamine.
Cell Reports July 24, 2026 Viktor J Oláh, Isabelle F Witteveen, Tue G Banke et al.
GABAergic inhibitory interneurons balance brain activity by suppressing excessive excitatory signaling and shaping network oscillations. Despite this critical function, our understanding of how neural circuits regulate GABAergic systems remains limited. Although N-methyl-D-aspartate receptor (NMDAR) functionality is defined by the GluN2A-D subunits, the interneuron NMDAR subunit composition...
Investigating the effects of chlorogenic acid on novel object recognition memory impairment, hyperlocomotion, and prefrontal BDNF expression in a sub-chronic ketamine-induced schizophrenia-like rat model
IBRO Neuroscience Reports July 24, 2026 Anahita Bahrami, Batool Ghorbani Yekta, Anita Baghdasarians
Schizophrenia is a severe neuropsychiatric disorder characterized by positive, negative, cognitive, mood-related, and motor symptoms. Sub-chronic ketamine administration is widely used to induce schizophrenia-like behavioral and cognitive alterations in rodents. Chlorogenic acid (CGA) is an abundant dietary phenolic acid with reported anti-inflammatory, antioxidative, and neuroprotective...
Comparative Electrocorticographic Signatures of S‑Ketamine and Racemic Ketamine in the Rat Visual Cortex Across Temporal Phases.
ACS Omega July 24, 2026
Comparative Electrocorticographic Signatures of S‑Ketamine and Racemic Ketamine in the Rat Visual Cortex Across Temporal Phases.
Rapid clinical and EEG microstate changes 24 h after intranasal esketamine in major depressive disorder with suicidal ideation: a prospective paired study.
Journal of Affective Disorders July 23, 2026
Rapid clinical and EEG microstate changes 24 h after intranasal esketamine in major depressive disorder with suicidal ideation: a prospective paired study.
A ketamine/methionine exposure paradigm, alone or combined with Lactobacillus rhamnosus GG, assessing schizophrenia-relevant behavioral, oxidative stress, and molecular endpoints in adult zebrafish.
Comp Biochem Physiol C Toxicol Pharmacol July 23, 2026
A ketamine/methionine exposure paradigm, alone or combined with Lactobacillus rhamnosus GG, assessing schizophrenia-relevant behavioral, oxidative stress, and molecular endpoints in adult zebrafish.
Ketamine abuse also affects sexual health
Sexual Medicine July 22, 2026 Eeke C M Leerssen, W. V. D. van der Sanden, V. D. de Kemp et al.
Abstract Introduction Recreational ketamine use is rapidly increasing, and ketamine-induced uropathy (KIU) is gaining recognition for its severe impact on quality of life (QoL), including pain, hematuria, lower urinary tract symptoms (LUTS), and potential negative effects on sexual function. This study investigates the prevalence of sexual dysfunction among men with KIU. Methods Male patients...
Esketamine in Treatment-Resistant Depression: Clinical and Translational Perspectives.
Current Neuropharmacology July 22, 2026
Esketamine in Treatment-Resistant Depression: Clinical and Translational Perspectives.
Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.
iScience July 21, 2026
Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.
How Music Affects Psychedelic & Ketamine Therapy: 41 Studies on How It Shapes Emotion, Imagery, Memory, and Surrender
Zenodo (CERN European Organization for Nuclear Research) July 21, 2026 Michael Alvear preprint
Music is often treated as an atmospheric accessory in psychedelic and ketamine therapy: useful, pleasant, optional, or merely calming. Across a curated evidence base of 41 studies, reviews, mechanistic papers, clinical reports, playlist-design papers, ketamine-specific studies, ceremonial-music papers, and counterarguments, music repeatedly appears as an active session-shaping variable. The...
The Hidden Architecture of Psychedelic Therapy How Music Shapes Emotion, Imagery, Memory, Surrender, and Ketamine Tolerability A White Paper Based on 41 Studies of Music in Psychedelic-
Zenodo (CERN European Organization for Nuclear Research) July 21, 2026 Michael Alvear preprint
Music is often treated as an atmospheric accessory in psychedelic and ketamine therapy: useful, pleasant, optional, or merely calming. That framing is too weak. Across a curated evidence base of 41 studies, reviews, mechanistic papers, clinical reports, playlist-design papers, ketamine-specific studies, ceremonial-music papers, and counterarguments, music repeatedly appears as an active...
Esketamine's Therapeutic Effect on Anhedonia: A Post-hoc of a Randomized Controlled Trial
Research Square July 20, 2026 Qianqian Wu, Weicheng Li, Zhanjie Luo et al. preprint
Abstract Background: Anhedonia, a prominent symptom of major depressive disorder (MDD), severely impairs patients' quality of life and is challenging to treat. Although esketamine has shown potential in treating anhedonia in adult treatment-resistant MDD, its effects on adolescents remain under-explored. Methods: In this study, a prospective, randomized, double-blind, controlled trial was...
Antidepressant-like effects of ketamine involve CX3CL1/CX3CR1 signaling-mediated synaptic plasticity in the mPFC
Translational Psychiatry July 20, 2026 Yong-Yu Yin, Si-Rui Sun, Hui-Ying Zhang et al.
Ketamine, a non-competitive N-methyl-D-aspartate acid (NMDA) receptor antagonist, produces rapid and sustained antidepressant actions, but the underlying molecular mechanism remains unclear. The CX 3 CL1/CX 3 CR1 signaling is closely related to mood disorders, and this study aims to investigate its role in ketamine’s antidepressant actions. We pharmacologically (AZD8797, a selective CX 3 CR1...
Sustained abstinence in severe ketamine use disorder following ibogaine treatment case report
Frontiers in Psychiatry July 20, 2026 Sergio Pérez Rosal, Sonya C. Faber, Markus Backmund
Substance use disorders (SUD) involving ketamine, cocaine, and alcohol present significant clinical challenges, often characterized by high relapse rates and limited pharmacological options. This case report details a 30-year-old male with a five-year history of severe polysubstance dependence, including daily intranasal ketamine use (2–3 g/day), cocaine, and alcohol, comorbid with recurrent...
Ketamine-induced analgesia and dissociation show distinct behavioral and neural correlates
Neuropsychopharmacology July 20, 2026 Noam Goldway, Itamar Jalon, Yara Agbaria et al.
Abstract Ketamine produces both analgesic and dissociative effects, but whether analgesia depends on dissociation remains debated. This question is part of a broader discussion on whether the subjective experiences elicited by psychoactive drugs are necessary for their therapeutic benefits. Here, we tested whether ketamine-induced analgesia and dissociation show separable behavioral and neural...