Neuroscience
July 27, 2026
Wei Zhao, Xinxin Zhao, Yunyun Zhang et al.
Major depressive disorder (MDD) is a leading cause of disability worldwide, and current antidepressants are limited by delayed onset and incomplete efficacy. Esketamine produces antidepressant effects more rapidly than conventional treatments, but its underlying mechanisms remain unclear. We examined whether cannabinoid type 1 receptor (CB1R) signaling is associated with hippocampal...
Molecules
May 23, 2024
Shiyun Li, Bin Wen, Wei Zhao et al.
4 citations
Depression is a chronic, severe, and often life-threatening neurological disorder. It not only causes depression in patients and affects daily life but, in severe cases, may lead to suicidal behavior and have adverse effects on families and society. In recent years, it has been found that sub-anesthetic doses of ketamine have a rapid antidepressant effect on patients with treatment-resistant...
Neuromolecular medicine
June 2016
Lap Ho, Patricia A. Bloom, Joan G Vega et al.
Caregiving for a dementia patient is associated with increased risk of psychological and physical health problems. We investigated whether a mindfulness-based stress reduction (MBSR) training course for caregivers that closely models the MBSR curriculum originally established by the Center of Mindfulness at the University of Massachusetts may improve the psychological resilience of...
Alzheimer s & Dementia
July 1, 2011
Lap Ho, Patricia A. Bloom, Joan Griffiths Vega et al.
4 citations
Numerous studies have documented that caregiving for a dementia patient may be associated with increased risk of emotional distress, depression, dementia, physical health problems, and death. Other studies suggest that targeting caregivers as the recipients of interventions may greatly improve Alzheimer's care, leading to reduced behavioral symptoms and increased length of time that the...