Neuroscience
July 27, 2026
Wei Zhao, Xinxin Zhao, Yunyun Zhang et al.
Major depressive disorder (MDD) is a leading cause of disability worldwide, and current antidepressants are limited by delayed onset and incomplete efficacy. Esketamine produces antidepressant effects more rapidly than conventional treatments, but its underlying mechanisms remain unclear. We examined whether cannabinoid type 1 receptor (CB1R) signaling is associated with hippocampal...
Zenodo (CERN European Organization for Nuclear Research)
May 23, 2026
Wei Zhao
Based on the existing theoretical framework, this paper conducts an in-depth interpretation of concepts related to cosmic self-perception and consciousness awakening, maintaining consistent overall logic. Consciousness awakening does not mean the universe possesses independent thinking and subjective thoughts. It is the continuous evolution and advancement of matter, which gradually builds...
Zenodo (CERN European Organization for Nuclear Research)
May 20, 2026
Wei Zhao
Abstract All subversive breakthroughs in modern physics contradict human daily intuition. Only the observable reality that the universe appears cold, silent and devoid of independent consciousness conforms to the current situation. Based on the established fact of extreme initial order during the Big Bang, this paper abandons two extreme viewpoints that the universe is eternally inert or...
Molecules (Basel, Switzerland)
May 23, 2024
Shiyun Li, Bin Wen, Wei Zhao et al.
4 citations
Depression is a chronic, severe, and often life-threatening neurological disorder. It not only causes depression in patients and affects daily life but, in severe cases, may lead to suicidal behavior and have adverse effects on families and society. In recent years, it has been found that sub-anesthetic doses of ketamine have a rapid antidepressant effect on patients with treatment-resistant...
Alzheimer s & Dementia
July 1, 2011
Lap Ho, Patricia A. Bloom, Joan Griffiths Vega et al.
4 citations
Numerous studies have documented that caregiving for a dementia patient may be associated with increased risk of emotional distress, depression, dementia, physical health problems, and death. Other studies suggest that targeting caregivers as the recipients of interventions may greatly improve Alzheimer's care, leading to reduced behavioral symptoms and increased length of time that the...