World models enable agents to learn and plan in imagination, but predictions beyond their experience can become unreliable and mislead decisions. Existing uncertainty estimates derived from predictions can remain overconfident on unfamiliar state-action pairs. We propose the Lucid World Model (LucidWM), which learns doubt from experience and propagates trust through imagination. By integrating...
Background Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused on perineuronal nets (PNNs), an extracellular matrix structure that surrounds fast-spiking parvalbumin-positive interneurons and regulates...
Esketamine has shown promise in mitigating tissue damage caused by ischemia- reperfusion injury, making it a potential therapeutic candidate for acute lung injury (ALI) induced by limb ischemia-reperfusion (LIR-ALI). This study sought to explore the role and mechanism of esketamine in the LIR-ALI rat model. The effects of esketamine on the LIR-ALI rats model were evaluated through...
To compare the characteristics of resting-state functional connectivity (FC) before and after repositioning therapy in patients with benign paroxysmal positional vertigo (BPPV) using functional near-infrared spectroscopy (fNIRS). Fifty BPPV patients and fifty healthy controls were enrolled. Oxygenated hemoglobin (HbO) concentration changes during resting-state were recorded using fNIRS. The...
Consciousness arises from the spatiotemporal neural dynamics, however, its relationship with neural flexibility and regional specialization remains elusive. We identified a consciousness-related signature marked by shifting spontaneous fluctuations along a unimodal-transmodal cortical axis. This simple signature is sensitive to altered states of consciousness in single individuals, exhibiting...
Consciousness is supported by rich neuronal dynamics to orchestrate behaviors and conscious processing can be disrupted by general anesthetics. Previous studies suggested that dynamic reconfiguration of large-scale functional network is critical for learning and higher-order cognitive function. During altered states of consciousness, how brain functional networks are dynamically changed and...