Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.
iScience July 21, 2026 DOI: 10.1016/j.isci.2026.116825 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Male mice |
| Intervention | Ketamine |
| Topics | Esketamine Ketamine |
| Key findings | Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice, suggesting that hierarchical status is an important factor in determining individual responses to stress and antidepressant treatment. |
Abstract
Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 7
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Science August 19, 2010
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets Science October 4, 2012
- Ketamine: Mechanisms and Relevance to Treatment of Depression. Annual Review of Medicine September 20, 2023
- Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron May 1, 2022
- Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation Science April 12, 2019
and 2 more in the library