Ketamine, a non-competitive N-methyl-D-aspartate acid (NMDA) receptor antagonist, produces rapid and sustained antidepressant actions, but the underlying molecular mechanism remains unclear. The CX 3 CL1/CX 3 CR1 signaling is closely related to mood disorders, and this study aims to investigate its role in ketamine’s antidepressant actions. We pharmacologically (AZD8797, a selective CX 3 CR1...
To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression. Randomised, double blind, placebo controlled trial with two parallel arms. Five tertiary care hospitals in China, 19 June 2020 to 3 August 2022. 364 mothers aged ≥18 years who had at least mild prenatal depression as indicated by Edinburgh...