Pharmacology, biochemistry, and behavior
July 26, 2026
Peng Zhang, Mengyu Wu, Keke Zhang et al.
Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potential side effects of repeated esketamine use. Here, we found that increasing extracellular signal-regulated kinase (ERK) activity by pharmacologically...
medRxiv
July 29, 2025
Yuwen He, Shan Lei, Wangli Si et al.
preprint
Abstract Background Somatic awareness is a fundamental practice for novice mindfulness practitioners. It has been proposed that mindfulness meditation training (MMT) enhances brain function through somatic awareness in both non-clinical and clinical populations. However, the neural signatures underlying this mechanism remain poorly understood. Methods In our study, we conducted mindfulness...
International Journal of Molecular Sciences
May 15, 2025
Xinyan Yang, Yinyu Chen, Gaolin Zheng et al.
3 citations
With rapid societal changes and increasing stress levels, the abuse of psychoactive substances has emerged as a global health crisis. Studies indicate that the mitochondrial calcium uniporter (MCU) plays a pivotal role in neurotoxic damage induced by psychoactive substances. As the primary channel for mitochondrial Ca2+ uptake, MCU dysfunction can lead to Ca2+ overload, oxidative stress, and...
Journal of Fungi
August 18, 2022
Sen Yao, Chuanzheng Wei, Hui Lin et al.
6 citations
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to detect the changes in psilocybin content after S-adenosyl-l-homocysteine (SAH) treatment and the changes of psilocybin content in different...