Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potential side effects of repeated esketamine use. Here, we found that increasing extracellular signal-regulated kinase (ERK) activity by pharmacologically...
medRxivJuly 29, 2025Yuwen He, Shan Lei, Wangli Si et al.
preprint
Abstract Background Somatic awareness is a fundamental practice for novice mindfulness practitioners. It has been proposed that mindfulness meditation training (MMT) enhances brain function through somatic awareness in both non-clinical and clinical populations. However, the neural signatures underlying this mechanism remain poorly understood. Methods In our study, we conducted mindfulness...
With rapid societal changes and increasing stress levels, the abuse of psychoactive substances has emerged as a global health crisis. Studies indicate that the mitochondrial calcium uniporter (MCU) plays a pivotal role in neurotoxic damage induced by psychoactive substances. As the primary channel for mitochondrial Ca2+ uptake, MCU dysfunction can lead to Ca2+ overload, oxidative stress, and...
Vitality is important for subjective well-being and performance, which makes strategies for its enhancement an important research issue. While prior research showed that mindfulness practice and physical exercise are both effective at enhancing vitality, no study has compared their efficacy. This study aimed to address this issue. Seventy-one Chinese adults participated in the study and were...
Journal of FungiAugust 18, 2022Sen Yao, Chuanzheng Wei, Hui Lin et al.6 citations
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to detect the changes in psilocybin content after S-adenosyl-l-homocysteine (SAH) treatment and the changes of psilocybin content in different...
NeuroimageDecember 1, 2021Runnan Cao, Chencan Qian, Shiwen Ren et al.
Face identity is represented at a high level of the visual hierarchy. Whether the human brain can process facial identity information in the absence of visual awareness remains unclear. In this study, we investigated potential face identity representation through face-identity adaptation with the adapting faces interocularly suppressed by Continuous Flash Suppression (CFS) noise, a modified...
Cigarette craving is a key contributor of nicotine addiction. Hypnotic aversion suggestions have been used to help smoking cessation and reduce smoking relapse rates but its neural basis is poorly understood. This study investigated the underlying neural basis of hypnosis treatment for nicotine addiction with resting state Electroencephalograph (EEG) coherence as the measure. The sample...