Electronic Physician
January 22, 2020
Mostafa Haghshenas, Fatemeh Assarian, Abdollah Omidi et al.
Background: Diseases with a chronic and debilitating nature, such as chronic kidney disease, are frequently associated with psychiatric disorders like anxiety and depression. Objective: To assess the efficacy of mindfulness-based stress reduction (MBSR) on anxiety and depression in hemodialysis patients. Methods: In this randomized clinical trial, fifty hemodialysis patients were selected from...
BMC Neurology
January 21, 2020
J. Hearn, A. Cross
Background Populations with reduced sensory and motor function, such as spinal cord injury (SCI) are at increased risk of depression, anxiety, pain, and poorer quality of life (QoL). Mindfulness-Based Interventions (MBIs) have been developed with the aim of improving outcomes for people with SCI. To understand the value of MBIs, a systematic review was conducted pertaining to the use of MBIs,...
Ukraïnsʹkij žurnal medicini bìologìï ta sportu
January 17, 2020
A. Kyselova, Chodakowska Warsaw Poland, E. Kravtsova et al.
Depression is one of the most common diagnoses which patients with mood disorders can hear every day. It is a serious condition which influences both physical and mental health. There are several causes of depression (for instance, abuse, certain medications, conflicts at home, work, school, university, etc). Basically, symptoms can vary from feelings of unhappiness and hopelessness to losing...
Indian Journal of Psychological Medicine
January 17, 2020
C S Gautam, Sonia S Mahajan, Jatin Sharma et al.
31 citations
Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor which also interacts with various other receptors that account for its myriad actions. Originally approved as a general anesthetic, it is being explored to be repurposed for numerous other indications such as depressive disorders, suicidal ideation, substance-use disorders, anxiety disorders, chronic pain,...
Gadjah Mada Journal of Professional Psychology
January 16, 2020
Resa Wuryansari
Condition of the prison which is very different from the outside world gives rise to many stressors for inmates living in it. It makes the inmates have a high risk to suffer from any psychological problems. One of the most common psychological problems is depression. Mindfulness for Prisoners (Mindfulners) was developed from Mindfulness Based Cognitive Therapy (MBCT) which is a form of...
Journal of Psychopharmacology
January 16, 2020
Lea J. Mertens, Matthew B. Wall, Leor Roseman et al.
211 citations
Background: Psilocybin has shown promise as a treatment for depression but its therapeutic mechanisms are not properly understood. In contrast to the presumed actions of antidepressants, we recently found increased amygdala responsiveness to fearful faces one day after open-label treatment with psilocybin (25 mg) in 19 patients with treatment-resistant depression, which correlated with...
Trials
January 8, 2020
Abhimanyu Sud, M. Nelson, Darren K. Cheng et al.
Background Despite the high prevalence of comorbid chronic pain and depression, this comorbidity remains understudied. Meditation has demonstrated efficacy for both chronic pain and depression independently, yet there have been few studies examining its effectiveness when both conditions are present concurrently. Furthermore, while meditation is generally accepted as a safe and effective health...
Trials
January 6, 2020
Artjom Frick, Isabel Thinnes, Ulrich Stangier
Depression is a widespread disorder with severe impacts for individuals and society, especially in its chronic form. Current treatment approaches for persistent depression have focused primarily on reducing negative affect and have paid little attention to promoting positive affect. Previous studies have shown that metta meditation increases positive affect in chronically depressed patients....
BMC Psychiatry
January 6, 2020
Sarah Frances, Frances Shawyer, Bruno Cayoun et al.
Effective transdiagnostic treatments for patients presenting with principal or comorbid symptoms of anxiety and depression enable more efficient provision of mental health care and may be particularly suitable for the varied population seen in primary healthcare settings. Mindfulness-integrated cognitive behavior therapy (MiCBT) is a transdiagnostic intervention that integrates aspects of CBT,...
Psychiatry Research
January 2, 2020
Simon B. Goldberg, Brian T. Pace, Christopher R. Nicholas et al.
234 citations
The current meta-analysis examined the effects of psilocybin in combination with behavioral interventions on anxiety and depression in samples with elevated symptoms. Across four studies (one uncontrolled; three randomized, placebo-controlled; N = 117), within-group pre-post and pre-follow-up effects on anxiety and depression were large (Hedges' gs=1.16 to 1.47) and statistically significant....
2020
Shotaro Niimi, J. Takeno
Abstract In this study the authors focused on mental disorders as functional disorders of human consciousness from the viewpoints of cognitive science and information science. They further focused their study on depression, a disorder that is the most frequently seen of mental disorders and whose cause is unclear. The authors propose a model of consciousness for the pathogenesis of major...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
January 2020
Rachael Sumner, Rebecca McMillan, Meg J. Spriggs et al.
The rapid-acting clinical effects of ketamine as a novel treatment for depression along with its complex pharmacology have made it a growing research area. One of the key mechanistic hypotheses for how ketamine works to alleviate depression is by enhancing long-term potentiation (LTP)-mediated neural plasticity. The objective of this study was to investigate the plasticity hypothesis in 30...
Academic Leadership Journal in Student Research
2020
Katelyn J. Haschke, Whitney Whitaker, Jordan Null et al.
Research indicates that practicing mindfulness over an extended period of time (e.g., 20-45 minutes a day) may positively impact an individual’s overall well-being; however, limited empirical attention has tested the effectiveness of brief mindfulness practices. The current study examined how brief mindfulness practices influence symptoms of depression, anxiety, and stress among college...
Applied Family Therapy Journal
2020
SeyedAliAsghar SeyedEbrahimi
Aim: The purpose of this research is the effectiveness of cognitive therapy based on mindfulness and positive thinking on improving mental health, perfectionism and cognitive emotion regulation strategies in family heads suffering from major depressive disorder. Method: The research method was semi-experimental with a pre-test-post-test design and follow-up with the control group. The...
Therapeutic Advances in Psychopharmacology
2020
Marcos Gómez‐revuelta, María Fernández-Rodríguez, Laura Boada-Antón et al.
Ketamine’s pharmacological profile makes it an interesting and useful drug to challenge treatment-resistant-depression (TRD). Emerging adverse events associated with single-slow-sub-anaesthetic doses for the treatment of depression are common, although generally transient and self-limited. Nevertheless, data on the safety of this practice are scarce. Thus, it seems timely before ketamine is...
Epidemiology and Psychiatric Sciences
2020
Chiara Gastaldon, D. Papola, G. Ostuzzi et al.
Abstract In March 2019, the US Food and Drug Administration (FDA) approved a nasal spray formulation of esketamine for the treatment of resistant depression in adults. Esketamine is the S-enantiomer of ketamine, an FDA-approved anaesthetic, known to cause dissociation and, occasionally, hallucinations. While ketamine has not been approved for depression in the USA or in any other country, it...
Advances in pharmacology (San Diego, Calif.)
2020
Lynnette A. Averill, Samar Fouda, James W. Murrough et al.
A paradigm shift in the conceptualization of the neurobiology of depression and the serendipitous discovery of ketamine's rapid-acting antidepressant (RAAD) effects has ushered in a new era of innovative research and novel drug development. Since the initial discovery of ketamine's RAAD effects, multiple studies have supported its short-term efficacy for fast-tracked improvements in...
Transpersonal Psychology Review
2020
Scott Buckler, April Woodward
A proposed direction for transpersonal psychology is the development of empirical research within the field, specifically in assessing the effects of transpersonal practices. The areas of self-actualisation, peak experience and flow have been subjected to research predominantly using psychometrics, however a range of theoretical and methodological issues within these concepts are evident. An...
Therapeutic advances in drug safety
2020
Mohammed S Salahudeen, Cameron M Wright, Gregory M Peterson
This narrative review aims to provide an overview of the current literature on the pharmacology, safety, efficacy and tolerability of intranasal esketamine, the S-enantiomer of ketamine, for the treatment of treatment-resistant depression (TRD). A literature search using Medline, Embase, PsycINFO and Cochrane Central was conducted (January 2000 to July 2019). Product information and...
Frontiers in Psychiatry
2020
Wei Liu, Qian Li, Binglu Ye et al.
Clinical studies have demonstrated that exposure to the inhalational general anesthetic nitrous oxide (N2O) produces antidepressant effects in depressed patients. However, the mechanisms underlying the antidepressant effects of N2O remain largely unknown. Neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) synthesis is essential for brain function and underlies the molecular...