Biological psychiatry. Cognitive neuroscience and neuroimaging

Distinct Connectivity Signatures of Hallucinatory Experiences and Neuromelanin Signal in Community-Dwelling Adolescents.

Biological psychiatry. Cognitive neuroscience and neuroimaging September 9, 2026 Philip N Tubiolo, Yash Patel, Alexandria Trepiccione et al.

Few human imaging studies investigate psychotogenic models during late adolescence. The "triple network" model posits that hallucinations are related to abnormal connectivity among the frontoparietal (FPN), default mode (DMN) and salience/cingulo-opercular (CON) networks but has not been tested during this age range, and is not well integrated with the hyper-dopaminergic model of psychosis. We...

DOI: 10.1016/j.bpsc.2026.09.002 Full text Adolescent Functional connectivity Hallucinations Neuromelanin +2

Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.

Biological psychiatry. Cognitive neuroscience and neuroimaging August 2026 Sophia H Blyth, Lauren D Hill, Anna Huang et al.

Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There...

DOI: 10.1016/j.bpsc.2025.12.014 Full text Default mode network Marijuana Adolescence Alcohol +3

Δ9-Tetrahydrocannabinol Alters Limbic and Frontal Functional Brain Connectomes Among Young Adult Cannabis Users.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2026 Zachary Anderson, Matthew Gunn, Emily Jones et al.

Cannabis use among young adults has reached the highest levels ever recorded. Evidence indicates that acute Δ9-tetrahydrocannabinol (THC) disrupts brain connectivity. Few studies have examined this on a whole-brain level. We examined the effects of a single moderate dose of THC on resting-state functional brain networks among young adult cannabis users. In a within-subject, double-blind,...

DOI: 10.1016/j.bpsc.2025.09.005 Full text Cannabis Frequency Independent component analysis Resting state +2

Major Depressive Disorder in Youth and Adults: A Quantitative Whole-Brain Meta-Analysis of Functional Magnetic Resonance Imaging Studies.

Biological psychiatry. Cognitive neuroscience and neuroimaging January 13, 2026 Caitlin Baten, Gladys Zamora, Amanda M. Klassen et al.

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder with limited treatment success in both youth and adults. Functional magnetic resonance imaging (fMRI) studies have reported partially differential patterns of activation in youth and adults diagnosed with MDD that may be attributable to age or length of illness. Following PRISMA guidelines, we searched PubMed through...

DOI: 10.1016/j.bpsc.2026.01.001 Full text Adults Quantitative whole-brain meta-analysis Youth

Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Vaibhav Tripathi, Ishaan Batta, Andre Zamani et al. 23 citations

The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition, self-projection, and theory of mind. In recent years, there has been a surge in the number of studies examining its functional connectivity, particularly its relationship with frontoparietal networks involved in top-down attention, executive...

DOI: 10.1016/j.bpsc.2024.12.016 Full text Meditation Attention Brain networks Functional connectivity +2

An Overview of Neurophenomenological Approaches to Meditation and Their Relevance to Clinical Research.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Antoine Lutz, Oussama Abdoun, Yair Dor-Ziderman et al. 18 citations

There is a renewed interest in taking phenomenology seriously in consciousness research, contemporary psychiatry, and neurocomputation. The neurophenomenology research program, pioneered by Varela, rigorously examines subjective experience using first-person methodologies, inspired by phenomenology and contemplative practices. This review explores recent advancements in neurophenomenological...

DOI: 10.1016/j.bpsc.2024.11.008 Full text Meditation Mindfulness Active inference Microphenomenology +2

Mindfulness Meditation and Network Neuroscience: Review, Synthesis, and Future Directions.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Ruchika S Prakash, Anita Shankar, Vaibhav Tripathi et al. 13 citations

Network neuroscience is an interdisciplinary field, which can be used to understand the brain by examining the connections between its constituent elements. In recent years, the application of network neuroscience approaches to study the intricate nature of the structural and functional relationships within the human brain has yielded unique insights into its organization. In this review, we...

DOI: 10.1016/j.bpsc.2024.11.005 Full text Mindfulness Brain organization Imaging Network neuroscience +1

ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Saampras Ganesan, Fernando A Barrios, Ishaan Batta et al. 6 citations

Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past...

DOI: 10.1016/j.bpsc.2024.10.015 Full text Meditation Mindfulness Consortium Enigma +1

Closed-Loop Systems and Real-Time Neurofeedback in Mindfulness Meditation Research.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Joseph C. C. Chen, David A Ziegler 6 citations

Mindfulness meditation has numerous purported benefits for psychological well-being; however, problems such as adherence to mindfulness tasks, quality of mindfulness sessions, or dosage of mindfulness interventions may hinder individuals from accessing the purported benefits of mindfulness. Methodologies including closed-loop systems and real-time neurofeedback may provide tools to help bolster...

DOI: 10.1016/j.bpsc.2024.10.012 Full text Meditation Mindfulness Closed-loop EEG +2

Using Electroencephalography to Advance Mindfulness Science: A Survey of Emerging Methods and Approaches.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Yanli Lin, Daniel A Atad, Anthony P Zanesco 4 citations

Throughout the brief history of contemplative neuroscience, electroencephalography (EEG) has been a valuable and enduring methodology used to elucidate the neural correlates and mechanisms of mindfulness. In this review, we provide a reminder that longevity should not be conflated with obsoletion and that EEG continues to offer exceptional promise for addressing key questions and challenges...

DOI: 10.1016/j.bpsc.2024.09.012 Full text Mindfulness Cognition Contemplative neuroscience EEG +2

Enhancing Equanimity With Noninvasive Brain Stimulation: A Novel Framework for Mindfulness Interventions.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Brian Lord, John J B Allen, Shinzen Young et al. 4 citations

Mindfulness has gained widespread recognition for its benefits for mental health, cognitive performance, and well-being. However, the multifaceted nature of mindfulness, which encompasses elements such as attentional focus, emotional regulation, and present-moment awareness, complicates its definition and measurement. A key component that may underlie its broad benefits is equanimity-the...

DOI: 10.1016/j.bpsc.2024.12.005 Full text Default mode network Mindfulness Cognitive control Emotional regulation +2

From Confound to Clinical Tool: Mindfulness and the Observer Effect in Research and Therapy.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Clemens C C Bauer, Daniel A Atad, Norman A. S. Farb et al. 3 citations

The observer effect (OE), the idea that observing a phenomenon changes it, has important implications across scientific disciplines involving measurement and observation. While often viewed as a confounding variable to control for, this paper argues that the OE should be seriously accounted for, explored, and systematically leveraged in research and clinical settings. Specifically, mindfulness...

DOI: 10.1016/j.bpsc.2025.01.012 Full text Meditation Awareness Introspection Measurement +2

Decoding Mindfulness With Multivariate Predictive Models.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Jarrod A Lewis-Peacock, Tor D Wager, Todd S. Braver 2 citations

Identifying the brain mechanisms that underlie the salutary effects of mindfulness meditation and related practices is a critical goal of contemplative neuroscience. Here, we suggest that the use of multivariate predictive models represents a promising and powerful methodology that could be better leveraged to pursue this goal. This approach incorporates key principles of multivariate decoding,...

DOI: 10.1016/j.bpsc.2024.10.018 Full text Meditation Mindfulness Cognitive neuroscience Contemplative neuroscience +2

Gamma Oscillations and Excitation/Inhibition Imbalance: Parallel Effects of NMDA Receptor Antagonism and Psychosis.

Biological psychiatry. Cognitive neuroscience and neuroimaging January 18, 2025 Brian J Roach, Judith M. Ford, Spero Nicholas et al. 7 citations

Auditory steady-state response (ASSR) abnormalities in the 40-Hz (gamma band) frequency have been observed in schizophrenia and in rodent studies of NMDA receptor (NMDAR) hypofunction. However, the extent to which 40-Hz ASSR abnormalities in schizophrenia resemble deficits in 40-Hz ASSR induced by acute administration of ketamine, an NMDAR antagonist, is not yet known. To address this knowledge...

DOI: 10.1016/j.bpsc.2025.01.008 Full text Ketamine Electroencephalography EEG Nmda receptor nmdar Schizophrenia +4

Psilocybin and 2C-B at Encoding Distort Episodic Familiarity.

Biological psychiatry. Cognitive neuroscience and neuroimaging October 1, 2024 Manoj K. Doss, Pablo Mallaroni, Natasha L. Mason et al. 7 citations

As research on psychedelics (hallucinogenic serotonin receptor 2A agonists) progresses, it is important to delineate the reliability of supposedly unique effects across this drug class. One such effect is how psychedelics impair the formation (i.e., encoding) of hippocampal-dependent recollections (retrieval of specific details) while potentially enhancing the encoding of cortical-dependent...

DOI: 10.1016/j.bpsc.2024.06.008 Full text Psilocybin 2c-b Episodic memory Familiarity +10

Functional Connectivity of the Auditory Cortex in Women With Trauma-Related Disorders Who Hear Voices.

Biological psychiatry. Cognitive neuroscience and neuroimaging October 1, 2024 Meiling Li, Lauren A M Lebois, Caitlin Ridgewell et al. 1 citation

Voice hearing (VH) is a transdiagnostic experience that is common in trauma-related disorders. However, the neural substrates that underlie trauma-related VH remain largely unexplored. While auditory perceptual dysfunction is among the abnormalities implicated in VH in schizophrenia, whether VH in trauma-related disorders also involves auditory perceptual alterations is unknown. We investigated...

DOI: 10.1016/j.bpsc.2024.06.009 Full text Auditory cortex Auditory verbal hallucinations Cerebellum Childhood trauma +2

Mindfulness Meditation Training Reduces Gaming Cravings by Reshaping the Functional Connectivity Between the Default Mode Network and Executive Control-Related Brain Regions.

Biological psychiatry. Cognitive neuroscience and neuroimaging August 1, 2024 Xuefeng Xu, Xuefeng Ma, Haosen Ni et al. 14 citations

Internet gaming disorder (IGD) can lead to psychological problems and cause behavioral problems in individuals. Traditional interventions have been ineffective in treating IGD. Meanwhile, mindfulness meditation (MM) is an emerging method that has proven to be effective for treating psychiatric disorders. In this study, MM was used to intervene in IGD and to explore its neural mechanism. Eighty...

DOI: 10.1016/j.bpsc.2024.04.011 Full text Default mode network Executive control network Functional connectivity Internet gaming disorder +1

Dynamic Functional Hyperconnectivity After Psilocybin Intake Is Primarily Associated With Oceanic Boundlessness.

Biological psychiatry. Cognitive neuroscience and neuroimaging July 1, 2024 Sepehr Mortaheb, Larry D. Fort, Natasha L. Mason et al. 15 citations

Psilocybin is a widely studied psychedelic substance that leads to the psychedelic state, a specific altered state of consciousness. To date, the relationship between the psychedelic state's neurobiological and experiential patterns remains undercharacterized because they are often analyzed separately. We investigated the relationship between neurobiological and experiential patterns after...

DOI: 10.1016/j.bpsc.2024.04.001 Full text Magic mushrooms Ego dissolution Psychedelics psilocybin Hallucinogens +8

Expectancy Effects in Psychedelic Trials.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2024 Balázs Szigeti, Boris D. Heifets 62 citations

Clinical trials of psychedelic compounds like psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltrptamine (DMT) have forced a reconsideration of how nondrug factors, such as participant expectations, are measured and controlled in mental health research. As doses of these profoundly psychoactive substances increase, so does the difficulty in concealing the treatment condition in the...

DOI: 10.1016/j.bpsc.2024.02.004 Full text Microdosing Hallucinogen therapy Clinical-trials trial design Psychedelic-therapy psychedelic medicine +6

Microdosing Psychedelics: Current Evidence From Controlled Studies.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2024 Robin J Murphy, Suresh Muthukumaraswamy, Harriet de Wit 31 citations

Taking regular low doses of psychedelic drugs (microdosing) is a practice that has drawn recent scientific and media attention for its potential psychotherapeutic effects. Yet, controlled studies evaluating this practice have lagged. Here, we review recent evidence focusing on studies that were conducted with rigorous experimental control. Studies conducted under laboratory settings using...

DOI: 10.1016/j.bpsc.2024.01.002 Full text Lysergic acid diethylamide LSD Psychedelics hallucinogens Microdosing sub-perceptual dosing +2

A Brief Historical Overview of Psychedelic Research.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2024 Mark A. Geyer 30 citations

Classical serotonergic psychedelics such as lysergic acid diethylamide or the naturally occurring compounds psilocybin and mescaline produce profound changes in mood, thought, intuition, sensory perception, the experience of time and space, and even the experience of self. Research examining psychedelic compounds has had a complex and turbulent evolution. Many cultures throughout the world have...

DOI: 10.1016/j.bpsc.2023.11.003 Full text LSD Psilocybin Psychotherapeutics Psychotomimetics +4

Effective Connectivity of Thalamocortical Interactions Following d-Amphetamine, LSD, and MDMA Administration.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2024 Mihai Avram, Felix Müller, Katrin H. Preller et al. 13 citations

While the exploration of serotonergic psychedelics as psychiatric medicines deepens, so does the pressure to better understand how these compounds act on the brain. We used a double-blind, placebo-controlled, crossover design and administered lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), and d-amphetamine in 25 healthy participants. By using spectral dynamic causal...

DOI: 10.1016/j.bpsc.2023.07.010 Full text LSD MDMA Dynamic causal modeling Effective connectivity +8

Spatial Correspondence of LSD-Induced Variations on Brain Functioning at Rest With Serotonin Receptor Expression.

Biological psychiatry. Cognitive neuroscience and neuroimaging July 1, 2023 Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri et al. 18 citations

Lysergic acid diethylamide (LSD) is an atypical psychedelic compound that exerts its effects through pleiotropic actions, mainly involving 1A/2A serotoninergic (5-HT) receptor subtypes. However, the mechanisms by which LSD promotes a reorganization of the brain's functional activity and connectivity are still partially unknown. Our study analyzed resting-state functional magnetic resonance...

DOI: 10.1016/j.bpsc.2023.03.009 Full text 5-ht2a Hallucinations Psychedelics LSD Acid +4

Interoception Underlies Therapeutic Effects of Mindfulness Meditation for Posttraumatic Stress Disorder: A Randomized Clinical Trial.

Biological psychiatry. Cognitive neuroscience and neuroimaging August 1, 2022 Seung Suk Kang, Scott R Sponheim, Kelvin O Lim

Mindfulness-based interventions have proven efficacy in treating posttraumatic stress disorder (PTSD), but the neurobiological mechanism underlying the therapeutic effects is unknown. As mindfulness meditation cultivates attention to the present moment and bodily sensations, neural functions related to interoception (i.e., central processes of bodily signals) might be such a mechanism. We...

DOI: 10.1016/j.bpsc.2021.10.005 Full text Meditation Mindfulness EEG Interoception +2

Δ9-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory.

Biological psychiatry. Cognitive neuroscience and neuroimaging 2020 Manoj K. Doss, Jessica Weafer, David A Gallo et al.

With the growing acceptance of cannabis use, it is crucial to understand the drug's effects on episodic memory accuracy and distortion. We investigated the impact of the administration of Δ9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, on a context-based memory illusion. In a double-blind, placebo-controlled, within-subjects design, healthy infrequent cannabis...

DOI: 10.1016/j.bpsc.2019.08.007 Full text Cannabis THC Context reinstatement Episodic memory +2

Papers