Journal of Affective Disorders
March 1, 2020
David S. Mathai, Matthew Meyer, Eric A. Storch et al.
The relationship between ketamine's hallucinogenic- and dissociative-type effects and antidepressant mechanism of action is poorly understood. This paper reviewed the correlation between subjective effects defined by various psychometric scales and observed clinical outcomes in the treatment of patients with Major Depressive Disorder (MDD). Based on PRISMA guidelines, we reviewed the...
Frontiers of Nursing
March 1, 2020
Yu-feng Li, Wenxiang Sun, Xiu-Jie Sun et al.
Abstract Objective The aim of this study was to assess the effectiveness of mindfulness meditation (MM) on anxiety, depression, stress and mindfulness in nursing students. Methods A comprehensive search and screening procedures were conducted to locate all MM interventions implemented with nursing students. For randomized controlled trials (RCTs) in accordance with the inclusion criteria, a...
Néphrologie & Thérapeutique
March 1, 2020
Angélique Thuillier Lecouf, Ludivine Videloup, Sandrine Letrecher et al.
The utilization of behavioral medicine, like Ericksonian hypnosis and mindfulness meditation, in the patient care is increasing. Psychological disorders associated with chronic renal failure are similar to the post-traumatic stress disorder and need a continuous personnel adjustment. Preventing depression, managing stress, pain and emotions, like anger, guiltiness and shame, is of importance in...
Psychology of Sport And Exercise
March 1, 2020
Ebrahim Norouzi, Markus Gerber, Frough Fattahi Masrour et al.
Abstract Objectives To test whether a mindfulness-based stress reduction (MBSR) program could reduce symptoms of anxiety, stress, and depression, and increase psychological well-being among retired Iranian football players compared to an active control group. Design Randomized controlled trial, with an 8-week MBSR intervention (16 group sessions, 90 min each) and an active control group. Three...
February 29, 2020
N. Gupta
Dr. Neeta Gupta Department of Psychology, DAV(PG) College, Dehradun. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History Received: 17 December 2019 Final Accepted: 20 January 2020...
International Journal of Fertility and Sterility
February 25, 2020
Fatemeh Kalhori, Seyedeh Zahra Masoumi, Farshid Shamsaei et al.
Background: Assisted reproductive technologies (ARTs) such as in vitro fertilization (IVF) can lead to depressive symptoms in infertile women due to their low success and high costs. Mindfulness-based group counseling can decrease depressive symptoms by increasing mental concentration. The aim of the present study was to evaluate the effect of mindfulness-based group counseling on depression in...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
February 25, 2020
Muris Humo, Beyza Ayazgök, Léa J. Becker et al.
Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socio-economic burden and result in disability affecting millions individuals, which urges the development of treatment strategies targeting this comorbidity. Ketamine, a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor,...
European Archives of Psychiatry and Clinical Neuroscience
February 20, 2020
Gustavo C. Leal, Igor D. Bandeira, Fernanda S. Correia-Melo et al.
257 citations
We aimed to analyze the efficacy and safety of arketamine, the R (−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery–Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion...
Chemico-Biological Interactions
February 19, 2020
Guo-Liang Liu, Yun-Feng Cui, Chang Lu et al.
Ketamine is gaining ground as a potential treating depression because it has a distinct mode of action than typical drugs that influence monoamine neurotransmitters including noradrenaline, dopamine, or serotonin. Ketamine is thought to act by blocking N-methyl-d-aspartate (NMDA) receptors in the brain, which interact with the amino acid neurotransmitter glutamate. The resultant chemical...
International Journal of Methods in Psychiatric Research
February 17, 2020
Nina K. Vollbehr, Rogier Hoenders, Agna A. Bartels‐Velthuis et al.
17 citations
OBJECTIVES: Despite the gains made by current first-line interventions for major depressive disorder (MDD), modest rates of treatment response and high relapse indicate the need to augment existing interventions. Following theory and initial research indicating the promise of mindful yoga interventions (MYIs), this study examines mindful yoga as a treatment of MDD. METHODS/DESIGN: This...
Medicina
February 9, 2020
Adam Włodarczyk, Wiesław Jerzy Cubała
22 citations
The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant bipolar depression (TRBD) affects up to 33% of depressive patients receiving treatment. Certain needs are still unmet and require new approaches. Many studies are in favor of treatments with...
Frontiers in Pharmacology
February 6, 2020
Shan Li, Xiaoxiao Luo, Dongyu Hua et al.
Patients are more likely to suffer from central nervous system (CNS) complications after anesthesia and surgery. However, postoperative depression (POD) has not yet received sufficient attentions, and its pathogenesis and therapeutic strategies remain poorly understood. We here aimed to investigate whether brain derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) signaling...
Spinal cord series and cases
February 4, 2020
Jace S Pincock, Alexandra L Terrill
Study design: Online survey of individuals with spinal cord injuries (SCI). Objective: This pilot study examined associations between mindfulness factors, resilience, and levels of depression and anxiety after SCI. Setting: Community-based; United States. Methods: A survey was posted online and shared with individuals with recent SCI (≤5 years). Results: Thirty-four individuals responded to the...
ACS Chemical Neuroscience
February 3, 2020
Jinghua Zhao, XueJie Liu, Daiyue Chang et al.
About 16% of the world's population has major depressive disorder. Traditional antidepressants have slow effect rates and low response rates. Many studies have shown that low doses of ketamine can produce rapid and effective antidepressant effects. However, its mechanism of action needs further exploration. Lipopolysaccharide (LPS) was used to establish a depression model in rats and PC12 nerve...
Stroke
February 1, 2020
Jennifer E S Beauchamp, Alejandro Chaoul, Stanley G. Cron et al.
Background and Purpose: Despite the high prevalence of post-stroke depression (PSD) and negative impact on stroke survivors (SS) and their informal caregivers ([IC]; e.g., unpaid spouses), treatment of PSD is inadequate. Meditation has been associated with improved psychological outcomes. The purpose of this study was to establish the feasibility and acceptability of a 12-week randomized...
Mindfulness
February 1, 2020
Alice E. Buxton, Carina Remmers, Hans-Peter Unger et al.
Abstract Objectives Recent preliminary evidence suggests that mindfulness-based programmes may be beneficial in the treatment of patients suffering from current depression. Due to the heterogeneity of patients with this diagnosis, a specialisation in treatment concepts for subgroups of patients may be beneficial. Methods This randomised controlled pilot study investigated the effectiveness of...
Psychiatric Annals
February 1, 2020
Hatice Guncu Kurt, Murat Altinay, Amit Anand
Patients who have not responded to two antidepressant trials in their current depressive episode are usually considered to have treatment-resistant depression (TRD). A detailed search on PubMed was conducted for reported response and remission rates for non-ketamine and ketamine treatments for TRD. From a variety of pharmacological and brain stimulation open-label studies, the treatments were...
Psychiatric Annals
February 1, 2020
Lynnette A. Averill, Christopher L. Averill, Chadi G. Abdallah
6 citations
The serendipitous discovery of ketamine's robust antidepressant effects has served as a major catalyst to usher in new era of drug development and a paradigm shift in our understanding of the neurobiology of chronic stress pathology (CSP). This review provides a selective synthesis of (1) the historical foundations of N-methyl-D-aspartate receptor modulators and the path to discovering...
Current Topics in Medicinal Chemistry
January 31, 2020
Domenico de Berardis, Carmine Tomasetti, Maurizio Pompili et al.
38 citations
BACKGROUND: A research on mood disorder pathophysiology has hypothesized abnormalities in glutamatergic neurotransmission, by suggesting further investigation on glutamatergic N-methyl-Daspartate (NMDA) receptor modulators in treating Major Depressive Disorder (MDD). Esketamine (ESK), an NMDA receptor antagonist able to modulate glutamatergic neurotransmission has been recently developed as an...
International Journal of Mental Health Nursing
January 28, 2020
Nicole Snaith, Philippa Rasmussen, Tim Schultz et al.
The aim of the study was to understand the perspectives of mental health consumers, staff, and yoga teachers on the characteristics of a yoga-based intervention to be developed for consumers with a long-term mental health condition, in addition to anxiety and/or depression. Two focus groups were held with mental health consumers (n = 8), two focus groups with mental health staff (n = 13) from a...