Neuroscience and biobehavioral reviews
January 2012
Johanna C Badcock, Kenneth Hugdahl
The continuum model of psychosis has been extremely influential. It assumes that psychotic symptoms, such as auditory verbal hallucinations (AVH), are not limited to patients with psychosis but also occur in healthy, non-clinical individuals - suggesting similar mechanisms of origin. Recent debate surrounding this model has highlighted certain differences, as well as similarities, in the...
Neuroscience and biobehavioral reviews
October 2011
Marie Vandekerckhove, Jaak Panksepp
This essay provides an overview of evolutionary levels of consciousness, with a focus on a continuum of consciousness: from primarily affective to more advanced cognitive forms of neural processing-from anoetic (without knowledge) consciousness based on affective feelings, elaborated by brain networks that are subcortical- and can function without neocortical involvement, to noetic (knowledge...
Neuroscience and biobehavioral reviews
August 19, 2011
Jaak Panksepp
The primal affects are intrinsic brain value systems that unconditionally and automatically inform animals how they are faring in survival. They serve an essential function in emotional learning. The positive affects index "comfort zones" that support survival, while negative affects inform animals of circumstances that may impair survival. Affective feelings come in several varieties,...
Neuroscience and biobehavioral reviews
July 2010
Ralf-Peter Behrendt
Recent advances in understanding hippocampal information processing offer new vistas on the mind-body and binding problems. Information encoded by the autoassociation network of cornu ammonis 3 (CA3) situates landmarks and objects within an allocentric framework of space and time. Guiding locomotion across the spatial environment, and generally organizing behaviour that transcends space and...
Neuroscience and biobehavioral reviews
2007
Kelly Allott, Jennifer Redman
Sex has been identified as an important factor in moderating the effects of several drugs of abuse. Given the increasing popularity of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) use, it is important for researchers and clinicians to understand the factors that may influence its pharmacological actions to improve education, harm reduction and treatment efforts. This review focuses on...
Neuroscience and biobehavioral reviews
June 2002
George R. Breese, Darin J Knapp, Sheryl S Moy
NMDA receptor antagonists worsen symptoms in schizophrenia and induce schizophrenic-like symptoms in normal individuals. In animals, NMDA antagonist-induced behavioral responses include increased activity, head weaving, deficits in paired pulse inhibition and social interaction, and increased forced swim immobility. Repeated exposure to NMDA antagonists in animals results in behavioral...
Neuroscience and biobehavioral reviews
March 2001
P Tassi, A Muzet
Consciousness remains an elusive concept due to the difficulty to define what has been regarded for many years as a subjective experience, therefore irrelevant for scientific study. Recent development in this field of research has allowed to provide some new insight to a possible way to define consciousness. Going through the extensive literature in this domain, several perspectives are...
Neuroscience and biobehavioral reviews
March 1999
K M Hegadoren, G B Baker, M Bourin
The 3,4-methylenedioxy analogues of amphetamine [MDMA ("Ecstasy", "Adam"), MDA ("Love") and MDE ("Eve")] are recreational drugs that produce feelings of euphoria and energy and a desire to socialize, which go far to explain their current popularity as "rave drugs". In addition to these positive effects, the drugs are relatively inexpensive to purchase and have the reputation of being safe...