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Sara W. Lazar

Massachusetts General Hospital, Harvard University

61 papers in the library · 9,860 citations · publishing 2000-2026

Papers

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Nonattachment Predicts Empathy, Rejection Sensitivity, and Symptom Reduction After a Mindfulness-Based Intervention Among Young Adults with a History of Childhood Maltreatment.

Mindfulness February 6, 2020 Diane Joss, Sara W. Lazar, Martin H. Teicher

Objectives: Individuals with a childhood maltreatment history tend to have various psychological symptoms and impaired social functioning. This study aimed to investigate the related therapeutic effects of a mindfulness-based intervention in this population. Methods: We analyzed self-report questionnaire scores of the Mindful Attention Awareness Scale (MAAS), Non-Attachment Scale (NAS), Adult...

DOI: 10.1007/s12671-020-01322-9 (opens in new tab) Full text (opens in new tab) Mindfulness Rejection sensitivity Empathy Childhood maltreatment +1

Brain network topology predicts participant adherence to mental training programs.

Network Neuroscience 2020 Marzie Saghayi, Jonathan Greenberg, Christopher O'Grady et al.

Adherence determines the success and benefits of mental training (e.g., meditation) programs. It is unclear why some participants engage more actively in programs for mental training than others. Understanding neurobiological factors that predict adherence is necessary for understanding elements of learning and to inform better designs for new learning regimens. Clustering patterns in brain...

DOI: 10.1162/netn_a_00136 (opens in new tab) Full text (opens in new tab) Meditation Graph theory Machine learning Mental training programs +1

Effects of a Mindfulness-Based Intervention on Self-Compassion and Psychological Health Among Young Adults With a History of Childhood Maltreatment

Frontiers in Psychology October 23, 2019 Diane Joss, Alaptagin Khan, Sara W. Lazar et al. 63 citations

Individuals who were maltreated during childhood are faced with increased risks for developing various psychological symptoms that are particularly resistant to traditional treatments. This pilot study investigated the effects of a mindfulness based behavioral intervention for young adults with childhood maltreatment history. This study looked at self-report psychological questionnaires from 20...

Moving beyond mindfulness: Defining equanimity as an outcome measure in meditation and contemplative research

October 3, 2019 Gaelle Desbordes, Tim Gard, Elizabeth A Hoge et al. 6 citations

In light of a growing interest in contemplative practices such as meditation, the emerging field of contemplative science has been challenged to describe and objectively measure how these practices affect health and well-being. While “mindfulness” itself has been proposed as a measurable outcome of contemplative practices, this concept encompasses multiple components, some of which, as we...

DOI: 10.31231/osf.io/48dgn (opens in new tab) Contemplation Psychotherapist Mindfulness meditation Valence chemistry +1

Measuring cognitive outcomes in mindfulness-based intervention research: a reflection on confounding factors and methodological limitations.

Current Opinion in Psychology August 1, 2019 David R. Vago, Resh S Gupta, Sara W. Lazar

One potential pathway by which mindfulness-based meditation improves health outcomes is through changes in cognitive functioning. Here, we summarize and comment upon three systematic reviews conducted over the last seven years that have had the goal of identifying the impact of mindfulness on cognitive outcomes. In our analysis, we identified a number of methodological limitations and potential...

Greater Anteroposterior Default Mode Network Functional Connectivity in Long-Term Elderly Yoga Practitioners

Frontiers in Aging Neuroscience July 2, 2019 Danilo Forghieri Santaella, Joana Bisol Balardin, Rui F. Afonso et al. 37 citations

Large-scale brain networks exhibit changes in functional connectivity during the aging process. Recent literature data suggests that Yoga and other contemplative practices may revert, at least in part, some of the aging effects in brain functional connectivity, including of the Default Mode Network (DMN). The aim of this cross-sectional investigation was to compare resting-state functional...

Strengthened Hippocampal Circuits Underlie Enhanced Retrieval of Extinguished Fear Memories Following Mindfulness Training.

Biological Psychiatry May 30, 2019 Gunes Sevinc, Britta K. Hölzel, Jonathan Greenberg et al.

Background: The role of hippocampus in context-dependent recall of extinction is well recognized. However, little is known about how intervention-induced changes in hippocampal networks relate to improvements in extinction learning. In this study, we hypothesized that mindfulness training creates an optimal exposure condition by heightening attention and awareness of present moment sensory...

How does mindfulness training improve moral cognition: A theoretical and experimental framework for the study of embodied ethics

November 12, 2018 Gunes Sevinc, Sara W. Lazar 8 citations

Mindfulness meditation has been primarily studied within the context of individual’s psychological well being and/or in relation to it’s potential to enhance cognitive skills such as attention and working memory. However, in Buddhism, mindfulness is used as a tool to cultivate wholesome actions, and as a means to promote virtuous, prosocial qualities. In this article, we postulate that...

How Does Mindfulness Affect Cognition? A Reflection on Confounding Issues Surrounding Mindfulness-based Intervention Research Targeting Cognitive Outcomes

November 2, 2018 David R. Vago, Resh S Gupta, Sara W. Lazar 3 citations

One potential pathway by which mindfulness-based meditation improves health outcomes is through changes in cognitive functioning. A systematic review of randomized controlled trials of mindfulness-based interventions (MBIs) was conducted with a focus on assessing the state of the evidence for effects on cognitive processes and associated assays. Here, we comment on confounding issues...

DOI: 10.31231/osf.io/86hrv (opens in new tab) Mindfulness Meditation Affect linguistics Psychological intervention +4

Compassionate hearts protect against wandering minds: Self-compassion moderates the effect of mind-wandering on depression.

Spirituality in Clinical Practice August 2, 2018 Jonathan Greenberg, Tanya Datta, Benjamin G. Shapero et al. 37 citations

Depression is associated with high levels of mind-wandering and low levels of self-compassion. However, little is known about whether and how these two factors interact with one another to influence depressive symptoms. The current study examined the interaction between mind-wandering, self-compassion and depressive symptoms in a depressed sample and tested the effects of an eight-week...

DOI: 10.1037/scp0000168 (opens in new tab) Mindfulness Self-compassion Moderation Clinical psychology +6

Common and Dissociable Neural Activity After Mindfulness-Based Stress Reduction and Relaxation Response Programs

Psychosomatic Medicine April 11, 2018 Gunes Sevinc, Britta K. Hölzel, Javeria A. Hashmi et al. 65 citations

OBJECTIVE: We investigated common and dissociable neural and psychological correlates of two widely used meditation-based stress reduction programs. METHODS: Participants were randomized to the Relaxation Response (RR; n = 18; 56% female) or the Mindfulness-Based Stress Reduction (MBSR; n = 16; 56% female) programs. Both programs use a "bodyscan" meditation; however, the RR program explicitly...

DOI: 10.1097/psy.0000000000000590 (opens in new tab) Meditation Mindfulness-based stress reduction Rumination Insula +6

Reduced interference in working memory following mindfulness training is associated with increases in hippocampal volume

Brain Imaging and Behavior March 17, 2018 Jonathan Greenberg, Victoria Romero, Seth Elkin-Frankston et al. 69 citations

Proactive interference occurs when previously relevant information interferes with retaining newer material. Overcoming proactive interference has been linked to the hippocampus and deemed critical for cognitive functioning. However, little is known about whether and how this ability can be improved or about the neural correlates of such improvement. Mindfulness training emphasizes focusing on...

Reiterated Concerns and Further Challenges for Mindfulness and Meditation Research: A Reply to Davidson and Dahl.

Perspectives on Psychological Science 2018 Nicholas T. van Dam, Marieke K. van Vugt, David R. Vago et al.

In response to our article, Davidson and Dahl offer commentary and advice regarding additional topics crucial to a comprehensive prescriptive agenda for future research on mindfulness and meditation. Their commentary raises further challenges and provides an important complement to our article. More consideration of these issues is especially welcome because limited space precluded us from...

A Randomized Controlled Pilot Study on Mindfulness-Based Cognitive Therapy for Unipolar Depression in Patients With Chronic Pain.

The Journal of Clinical Psychiatry 2018 Marasha De Jong, Frenk Peeters, Tim Gard et al.

Chronic pain is a disabling illness, often comorbid with depression. We performed a randomized controlled pilot study on mindfulness-based cognitive therapy (MBCT) targeting depression in a chronic pain population. Participants with chronic pain lasting ≥ 3 months; DSM-IV major depressive disorder (MDD), dysthymic disorder, or depressive disorder not otherwise specified; and a 16-item Quick...

Mind the Hype: A Critical Evaluation and Prescriptive Agenda for Research on Mindfulness and Meditation

Perspectives on Psychological Science October 10, 2017 Nicholas T. van Dam, Marieke K. van Vugt, David R. Vago et al. 1,500 citations

During the past two decades, mindfulness meditation has gone from being a fringe topic of scientific investigation to being an occasional replacement for psychotherapy, tool of corporate well-being, widely implemented educational practice, and "key to building more resilient soldiers." Yet the mindfulness movement and empirical evidence supporting it have not gone without criticism....

Greater Cortical Thickness in Elderly Female Yoga Practitioners-A Cross-Sectional Study.

Frontiers in Aging Neuroscience 2017 Rui F. Afonso, Joana B Balardin, Sara W. Lazar et al.

Yoga, a mind-body activity that requires attentional engagement, has been associated with positive changes in brain structure and function, especially in areas related to awareness, attention, executive functions and memory. Normal aging, on the other hand, has also been associated with structural and functional brain changes, but these generally involve decreased cognitive functions. The aim...

Mindfulness-based cognitive therapy for depressed individuals improves suppression of irrelevant mental-sets

European Archives of Psychiatry and Clinical Neuroscience November 9, 2016 Jonathan Greenberg, Benjamin G. Shapero, David Mischoulon et al. 17 citations

An impaired ability to suppress currently irrelevant mental-sets is a key cognitive deficit in depression. Mindfulness-based cognitive therapy (MBCT) was specifically designed to help depressed individuals avoid getting caught in such irrelevant mental-sets. In the current study, a group assigned to MBCT plus treatment-as-usual (n = 22) exhibited significantly lower depression scores and...

DOI: 10.1007/s00406-016-0746-x (opens in new tab) Full text (opens in new tab) Mindfulness-based cognitive therapy Cognition Depression economics Clinical psychology +3

Effects of Mindfulness-Based Cognitive Therapy on Body Awareness in Patients with Chronic Pain and Comorbid Depression

Frontiers in Psychology June 30, 2016 Marasha De Jong, Sara W. Lazar, Kiran Hug et al. 200 citations

Body awareness has been proposed as one of the major mechanisms of mindfulness interventions, and it has been shown that chronic pain and depression are associated with decreased levels of body awareness. We investigated the effect of Mindfulness-Based Cognitive Therapy (MBCT) on body awareness in patients with chronic pain and comorbid active depression compared to treatment as usual (TAU; N =...

DOI: 10.3389/fpsyg.2016.00967 (opens in new tab) Mindfulness-based cognitive therapy Clinical psychology Depression economics Population +7

Mindfulness-Based Stress Reduction, Fear Conditioning, and The Uncinate Fasciculus: A Pilot Study.

Frontiers in Behavioral Neuroscience 2016 Britta K. Hölzel, Vincent Brunsch, Tim Gard et al.

Mindfulness has been suggested to impact emotional learning, but research on these processes is scarce. The classical fear conditioning/extinction/extinction retention paradigm is a well-known method for assessing emotional learning. The present study tested the impact of mindfulness training on fear conditioning and extinction memory and further investigated whether changes in white matter...

Contemplating Mindfulness at Work

Journal of Management November 19, 2015 Darren J. Good, Christopher J. Lyddy, Theresa M. Glomb et al. 1,007 citations

Mindfulness research activity is surging within organizational science. Emerging evidence across multiple fields suggests that mindfulness is fundamentally connected to many aspects of workplace functioning, but this knowledge base has not been systematically integrated to date. This review coalesces the burgeoning body of mindfulness scholarship into a framework to guide mainstream management...

Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls.

Frontiers in Human Neuroscience 2015 Tim Gard, Maxime Taquet, Rohan Dixit et al.

There has been a growing interest in understanding how contemplative practices affect brain functional organization. However, most studies have restricted their exploration to predefined networks. Furthermore, scientific comparisons of different contemplative traditions are largely lacking. Here we explored differences in whole brain resting state functional connectivity between experienced...

DOI: 10.3389/fnhum.2015.00137 (opens in new tab) Full text (opens in new tab) Aging Basal ganglia-thalamocortical circuits Caudate Degree centrality +4

Fluid intelligence and brain functional organization in aging yoga and meditation practitioners

DOAJ (DOAJ: Directory of Open Access Journals) April 1, 2014 Tim Gard, Tim eGard, Maxime eTaquet et al. 104 citations

Numerous studies have documented the normal age-related decline of neural structure, function, and cognitive performance. Preliminary evidence suggests that meditation may reduce decline in specific cognitive domains and in brain structure. Here we extended this research by investigating the relation between age and fluid intelligence and resting state brain functional network architecture...

DOI: 10.3389/fnagi.2014.00076 (opens in new tab) Meditation Mindfulness Psychological resilience Resting State FMRI +4

Change in Brainstem Gray Matter Concentration Following a Mindfulness-Based Intervention is Correlated with Improvement in Psychological Well-Being

Frontiers in Human Neuroscience 2014 Omar Singleton, Britta K. Hölzel, Mark Vangel et al. 116 citations

Individuals can improve their levels of psychological well-being (PWB) through utilization of psychological interventions, including the practice of mindfulness meditation, which is defined as the non-judgmental awareness of experiences in the present moment. We recently reported that an 8-week-mindfulness-based stress reduction (MBSR) course lead to increases in gray matter concentration in...

DOI: 10.3389/fnhum.2014.00033 (opens in new tab) Pons Brainstem Tegmentum Mindfulness-based stress reduction +9

The potential effects of meditation on age-related cognitive decline: a systematic review.

Annals of the New York Academy of Sciences 2014 Tim Gard, Britta K. Hölzel, Sara W. Lazar

With a rapidly aging society it becomes increasingly important to counter normal age-related decline in cognitive functioning. Growing evidence suggests that cognitive training programs may have the potential to counteract this decline. On the basis of a growing body of research that shows that meditation has positive effects on cognition in younger and middle-aged adults, meditation may be...

Mindfulness and self-compassion in generalized anxiety disorder: examining predictors of disability.

Evidence-based Complementary and Alternative Medicine September 23, 2013 Elizabeth A Hoge, Britta K. Hölzel, Luana Marques et al.

Generalized anxiety disorder (GAD) is a condition characterized by worry and physiological arousal symptoms that causes significant disabilities in patients' lives. In order to improve psychotherapeutic interventions, a careful characterization of the deficiencies of this population as well as factors that ameliorate disability is crucial. Variables that have not traditionally been the focus of...