Psychiatry research. Neuroimaging
March 1, 2025
Michael Datko, Jacqueline Lutz, Richa Gawande et al.
1 citation
Behavior change often requires overcoming discomfort or difficult emotions. Emotional dysregulation associated with anxiety or depression may prevent behavior change initiation among people managing chronic illness. Mindfulness training may catalyze chronic disease self-management by reducing experiential avoidance of aversive experiences that act as barriers to change initiation. Using a fMRI...
Psychiatry research. Neuroimaging
December 1, 2022
Michael Datko, Jacqueline Lutz, Richa Gawande et al.
Interoceptive dysfunction is often present in anxiety and depression. We investigated the effects of an 8-week intervention, Mindfulness Training for Primary Care (MTPC), on brain mechanisms of interoceptive attention among patients with anxiety and/or depression. We hypothesized that fMRI brain response to interoception in the insula, a region known for interoceptive processing, would increase...
Frontiers in Psychology
November 22, 2021
Willoughby B. Britton, Gaelle Desbordes, Rebecca L. Acabchuk et al.
77 citations
Self-related processes (SRPs) have been theorized as key mechanisms of mindfulness-based interventions (MBIs), but the evidence supporting these theories is currently unclear. This evidence map introduces a comprehensive framework for different types of SRPs, and how they are theorized to function as mechanisms of MBIs (target identification). The evidence map then assesses SRP target...
Pain medicine (Malden, Mass.)
October 1, 2020
Michael P Berry, Jacqueline Lutz, Zev Schuman-Olivier et al.
Self-compassion meditation, which involves compassion toward the self in moments of suffering, shows promise for improving pain-related functioning, but its underlying mechanisms are unknown. This longitudinal, exploratory pilot study investigated the effects of a brief (eight contact hours, two weeks of home practice) self-compassion training on pain-related brain processing in chronic low...
October 3, 2019
Gaelle Desbordes, Tim Gard, Elizabeth A Hoge et al.
6 citations
In light of a growing interest in contemplative practices such as meditation, the emerging field of contemplative science has been challenged to describe and objectively measure how these practices affect health and well-being. While “mindfulness” itself has been proposed as a measurable outcome of contemplative practices, this concept encompasses multiple components, some of which, as we...
Focus (Am Psychiatr Publ)
January 24, 2018
Benjamin G. Shapero, Jonathan Greenberg, Paola Pedrelli et al.
165 citations
Mindfulness meditation has a longstanding history in eastern practices that has received considerable public interest in recent decades. Indeed, the science, practice, and implementation of Mindfulness Based Interventions (MBIs) have dramatically increased in recent years. At its base, mindfulness is a natural human state in which an individual experiences and attends to the present moment....
BMC Complementary and Alternative Medicine
June 1, 2012
Gaelle Desbordes, Riccardo Barbieri, Luca Citi et al.
We collected electrocardiogram recordings as part of a larger randomized controlled trial of the effects of an eight-week meditation training intervention on healthy adults without prior meditation experience. Here we report data from eight subjects before and after the “mindful-attention” meditation intervention and the control intervention. The recordings were performed while the subjects...
Frontiers in Human Neuroscience
2012
Gaelle Desbordes, Lobsang Negi, Thaddeus W W Pace et al.
445 citations
The amygdala has been repeatedly implicated in emotional processing of both positive and negative-valence stimuli. Previous studies suggest that the amygdala response to emotional stimuli is lower when the subject is in a meditative state of mindful-attention, both in beginner meditators after an 8-week meditation intervention and in expert meditators. However, the longitudinal effects of...
Gaelle Desbordes, Lobsang Negi
While modern neuroscience relies on objective, quantitative methods for measuring how mental events manifest as brain activity, ancient contemplative traditions have used first-person introspective practices to gain a greater understanding of the mind. It is now possible to combine these different approaches, hopefully in a mutually enriching, synergistic way. The scientific study of the mind...