Science
October 27, 1967
William D. Loughman, Thornton W. Sargent, David M. Israelstam
94 citations
Leukocyte cultures from eight human subjects who had had recent exposure to large doses of lysergic acid diethylamide were examined for chromosome abnormalities. The number of abnormalities was not significantly greater than that in control cultures.
Science
January 13, 1967
L. P. Gilmour, R. D. O’brien
7 citations
Psilocybin, a hallucinogen, formed a blue color with a subfraction of rat-brain mitochondria believed to contain nerve-ending particles. Color formation increased with p H, did not require oxygen, and involved a component that could not be solubilized. The effect was not shown by chemically related neuroactive compounds, such as bufotenine and serotonin, and was antagonized by only tyramine or...
Archives of Neurology
July 1, 1963
Jun Wada
41 citations
Introduction The significance to behavior of biologically active amines normally present in the mammalian brain has been receiving increased attention by workers in diversified fields in recent years. This trend has been accelerated by the recognition that a number of potent psychotherapeutic agents seem to assert their beneficial effects by influencing these amines in various ways. For...
American Journal of Physiology-Legacy Content
July 1, 1962
Peter K. Gessner, Irvine H. Page
64 citations
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25. 5-Methoxy-N:N-dimethyltryptamine, at a dose level of 19 µm/kg, had a pronounced effect on the conditioned avoidance response, much more pronounced than that due to the known psychotomimetic...
Science
August 4, 1961
Julius Axelrod
183 citations
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
Journal of Mental Science
October 1, 1958
J. C. Brengelmann, C. M. B. Pare, M. Sandler
31 citations
In the investigation described, the hypothesis was tested that 5-hydroxytryptamine (5HT) acts to reduce the psychological effects of lysergic acid diethylamide (LSD). The method was to inject 5-hydroxytryptophan (5HTP) prior to LSD and to compare the results of psychological tests performed after these injections. Placebo controls were used.
Annals of Internal Medicine
May 1, 1958
Nicholas T. Richards, Latasha Chapman, H Goodell et al.
16 citations
Case Reports1 May 1958LSD-LIKE DELIRIUM FOLLOWING INGESTION OF A SMALL AMOUNT OF ITS BROM ANALOG (BOL-148)NELSON RICHARDS, LORING F. CHAPMAN, HELEN GOODELL, HAROLD G. WOLFF, F.A.C.P.NELSON RICHARDSSearch for more papers by this author, LORING F. CHAPMANSearch for more papers by this author, HELEN GOODELLSearch for more papers by this author, HAROLD G. WOLFF, F.A.C.P.Search for more papers by...
The Japanese Journal of Pharmacology
1958
Hiroshi Takagi, Shigeru Yamamoto, Shuji Takaori et al.
11 citations
In 1943 in Switzerland, A. Hofmann (1) working on the synthesis of lysergic acid diethylamide (LSD-25), a common fragment of ergot alkaloids, noticed the peculiar sensation of vertigo and restlessness. Thenceforce it was reported by Stoll et al. (1, 2), Forrer et al. (3) and Rinkel et al. (4) that a small dose of LSD caused predominantly schizophrenic symptoms that were manifested in...
Experimental Biology and Medicine
March 1, 1957
Parkhurst A. Shore, B.b. Brodie
60 citations
1. Administration of reserpine to rabbits pretreated with the monoamine oxidase inhibitor, iproniazid, causes excitation and sympathomimetic effects similar to those observed after administration of LSD or high doses of 5-hydroxytryptophan. These effects are associated with the presence of a high concentration of free serotonin in the brain. The observations are consistent with the concept that...
American Journal of Therapeutics
Burton J. Tabaac, Kenneth Shinozuka, Mahdi Fadel et al.
Mescaline (3,4,5-trimethoxyphenethylamine) is a classic serotonergic psychedelic with a history of indigenous ceremonial use. There is renewed scientific interest in mescaline because of the potential psychiatric benefits of psychedelic-assisted therapy. Mescaline primarily exerts its psychoactive effects through serotonin-2A (5-HT 2A ) receptor agonism. There is a lack of controlled clinical...