Serotonin: all studies (page 100) - The Consciousness Library

Effects of ritanserin on the 3,4-methylenedioxymethamphetamine-induced decrease in striatal serotonin concentration and on the increase in striatal neurotensin and dynorphin A concentrations.

Biochemical Pharmacology August 1, 1993 M Johnson, L G Bush, Glen R. Hanson et al.

The concentration of serotonin (5-HT) measured in rat striatum was reduced to 75% of control 1 week after a single subcutaneous administration of dl-3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg). This decrease was prevented by pretreating the animals with ritanserin. Eighteen hours after MDMA (20 mg/kg), striatal concentrations of neurotensin-like immunoreactivity (NTLI) and of dynorphin...

DOI: 10.1016/0006-2952(93)90568-h Serotonin Corpus striatum Animals Rats, sprague-dawley +6

3,4-Methylenedioxymethamphetamine, serotonin and memory.

Journal of Pharmacology and Experimental Therapeutics August 1, 1993 George A. Ricaurte, A L Markowska, G L Wenk et al.

The recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is toxic to central serotonin (5-HT) neurons, but few long-term functional consequences of MDMA neurotoxicity have been identified. Because 5-HT has been implicated in learning and memory, the present study was undertaken to examine whether MDMA, by damaging 5-HT neurons, altered mnemonic function on a long-term...

DOI: 10.1016/s0022-3565(25)38362-x Serotonin Animals Rats N-methyl-3,4-methylenedioxyamphetamine +8

Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate.

Neurotoxicology and Teratology March 1, 1993 S F Ali, Glenn D. Newport, Andrew C. Scallet et al.

MDMA (3,4-methylenedioxymethamphetamine) has been reported to produce serotonergic depletion in nonhuman primates at doses as low as 2.5 mg/kg (1-2 times the typical human dose). The current study evaluated the dose-response relationships of MDMA (1.25-20.0 mg/kg) using regional concentrations of serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and home cage behavior as...

DOI: 10.1016/0892-0362(93)90067-x Serotonin Brain Animals Macaca mulatta +9

The serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine facilitates noradrenaline release from rat spinal cord slices and inhibits monoamine oxidase activity.

General pharmacology March 1, 1993 W Reimann, F Schneider 17 citations

1. The influences of the purported serotonergic agonist 5-methoxy-N,N-dimethyltryptamine (MeODMT) on noradrenaline release and metabolism were investigated in a rat spinal cord release model and a monoamine oxidase (MAO) assay. 2. MeODMT inhibited the basal outflow of tritium from rat spinal cord slices preincubated with [3H]noradrenaline and enhanced the electrically-evoked overflow. 3....

DOI: 10.1016/0306-3623(93)90331-q Full text

LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: Intracellular studies in rat facial motoneurons

Synapse February 1, 1993 Jennifer C. Garratt, Meenakshi Alreja, George K. Aghajanian 46 citations

Abstract The effects of LSD (d‐lysergic acid diethylamide) on rat facial motoneurons were compared to those of 5‐hydroxytryptamine (5‐HT) in brain slices by means of current clamp and single‐electrode voltage‐clamp recordings. As previously reported, 5‐HT, in part by decreasing a resting potassium conductance, produced a reversible depolarization (∼5 mV), an increase in input resistance, and an...

DOI: 10.1002/syn.890130205 Serotonin Ritanserin Spiperone Depolarization +10

Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy

European Journal of Pharmacology January 5, 1993 Lubo Zhang, Donald C. Dyer 7 citations

d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial...

DOI: 10.1016/0014-2999(93)90420-m Full text

Effects of cortical serotonin depletion induced by 3,4-methylenedioxymethamphetamine (MDMA) on behavior, before and after additional cholinergic blockade.

Neuropsychopharmacology 1993 T E Robinson, E Castañeda, I Q Whishaw

Repeated treatment with high doses of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") produces a long-lasting depletion of brain serotonin, presumably because of the degeneration of serotonin axon terminals. However, very little is known about the long-term behavioral consequences of MDMA neurotoxicity. The experiments reported here were designed to evaluate the effects of MDMA...

DOI: 10.1038/npp.1993.9 Serotonin Prosencephalon Animals Rats, sprague-dawley +5

p-methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent.

European Journal of Pharmacology December 8, 1992 X Huang, D Marona-Lewicka, D E Nichols 62 citations

p-Methylthioamphetamine (MTA), was compared to p-chloroamphetamine (PCA) in a number of pharmacological assays. MTA was about 2-fold more potent than PCA at inhibiting synaptosomal uptake of [3H]5-hydroxytryptamine ([3H]5-HT), and about 7-fold and 10-fold less potent than PCA at inhibiting synaptosomal uptake of [3H]dopamine and [3H]norepinephrine, respectively. In drug discrimination assays,...

DOI: 10.1016/0014-2999(92)90282-9 Full text

5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine

European Journal of Pharmacology November 1, 1992 Christopher J. Schmidt, Gina M. Fadayel, Christine K. Sullivan et al. 162 citations

The highly selective 5-HT2 receptor antagonist, MDL 100,907, was used to explore the role of serotonin in the stimulation of dopaminergic function produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA). MDL 100,907 blocked MDMA-stimulated dopamine synthesis in vivo without affecting basal synthesis. The long-term deficits in 5-HT concentrations believed to be a...

DOI: 10.1016/0014-2999(92)90819-p MDMA Dopaminergic Amphetamine Pharmacology +4

5-HT2/5-HT1C receptor-mediated facilitatory action on unit activity of ventral horn cells in rat spinal cord slices.

European Journal of Pharmacology September 22, 1992 J Yamazaki, H Fukuda, T Nagao et al. 38 citations

5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) facilitate motoneuron excitability through 5-HT1C/5-HT2 receptors in rats. Using spinal cord slices prepared from adult rats, we recorded unitary cell discharges, evoked by local stimulation of the adjacent site, extracellularly in the motor nuclei of the ventral horn. 5-MeODMT, DOI,...

DOI: 10.1016/0014-2999(92)90753-q Full text

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