Stereochemical considerations and total valence electron calculations suggest congruities among the ostensibly dissimilar hallucinogenic compounds, D-lysergic acid diethylamide (LSD), indolcalkylamines, and methoxylated amphetamines. In LSD the aromatic benzene ring A and the N-6 nitrogen are essential for hallucinogenic activity; these sites may react with the receptor. The conformations of...
THE actions of hallucinogenic agents have been correlated with Hückel molecular orbital calculations of the π-elections^1 and with fluorescent properties^2. The Hückel correlations on three methoxylated amphetamines indicated that hallucinogenic activity correlated with energy of the highest occupied molecular orbital^1.