Chromosome Abnormality in Offspring of LSD User
JAMA February 9, 1970 DOI: 10.1001/jama.1970.03170060051010 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Newborn girl with trisomy 13 |
| Topics | LSD |
| Keywords | Offspring Trisomy Chromosomal translocation Pregnancy Chromosomal rearrangement Chromosome Abnormality Genetics Buthidae Karyotype Andrology |
| Citations | 33 |
| Key findings | Lysergic acid diethylamide use prior to conception may have induced chromosomal rearrangement leading to trisomy 13 in the offspring. |
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
Citations in the library
Cited by 7
- LSD and Genetic Damage Science April 30, 1971
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Multiple Ocular Anomalies Associated With Maternal LSD Ingestion Archives of Ophthalmology February 1, 1978
- Effect of LSD on Human Pregnancy JAMA June 1, 1970
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
and 2 more in the library