Chromosome Studies on Patients (in Vivo) and Cells (in Vitro) Treated with Lysergic Acid Diethylamide
Margaret J. Corey, J. C. Andrews, M.Josephine McLeod, J. Ross MacLean, W. E. Wilby
New England Journal of Medicine April 23, 1970 DOI: 10.1056/nejm197004232821702 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Prospective study and in vitro study Peer reviewed |
|---|---|
| Sample size | 21 |
| Population | Patients given d-lysergic acid diethylamide 25 and untreated controls |
| Intervention | d-lysergic acid diethylamide 25 |
| Dose | 25 μg |
| Duration | 24 hours |
| Topics | LSD |
| Citations | 25 |
| Key points | Therapeutic administration of d-lysergic acid diethylamide 25 does not produce chromosomal damage. |
Abstract
In a prospective study of 10 patients given d-lysergic acid diethylamide 25, there was no difference in frequency of chromosome breakage between samples obtained immediately before and 24 hours after treatment. In 11 patients, treated over periods ranging from 24 hours to eight years before sampling, the frequency of chromosomal breaks did not differ from that found in untreated controls. In an in vitro study the frequency of chromosomal breaks was increased in replicate cultures from each of 10 subjects when 1 μg per milliliter of d-lysergic acid diethylamide 25 was added during the last 24 hours of culture. There is no cytogenetic evidence that d-lysergic acid diethylamide 25 given therapeutically produces chromosomal damage. The chromosomal aberrations found after illicit use of the drug remain unexplained.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 4
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
- Is psychedelic use associated with cancer?: Interrogating a half-century-old claim using contemporary population-level data Journal of Psychopharmacology August 16, 2022
- LSD- und Cannabis-Konsum während der frühen Schwangerschaft mit gutem perinatalen Ausgang Gynäkologisch-geburtshilfliche Rundschau 1999
Cites 5
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967
- Chromosomal Effect in vivo of Exposure to Lysergic Acid Diethylamide Science June 21, 1968